Cell Line : NCI-H1648
Cellosaurus Index : CVCL_1482
Cellosaurus ID : NCI-H1648
CCLE Name
: NCIH1648_LUNG
CTRP2 Name
: NCIH1648
GDSC1 Name
, GDSC2 Name
: NCI-H1648
Cancer Type : lung
Dataset : All
Drug Response Information
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Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.
Experimental information
Experimental information from All dataset, including cell line name, drug name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.
| Cellosaurus ID | Drug Name | Original Dataset(s) | Min Dose | Max Dose | Dose-response |
|---|---|---|---|---|---|
| NCI-H1648 | (5Z)-7-Oxozeaenol | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | 5-azacytidine | GDSC2 | 0.0200 | 20.0000 |
|
| NCI-H1648 | 5-Fluorouracil | GDSC1,GDSC2 | 0.0200 | 32.0000 |
|
| NCI-H1648 | 965-D2 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | 993-D2 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | A-366 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | A-443654 | GDSC1 | 0.0040 | 1.0240 |
|
| NCI-H1648 | A-770041 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | A-83-01 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | ABT737 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | ACY-1215 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | AEW541 | CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | Afatinib | GDSC1,GDSC2 | 0.0020 | 10.0000 |
|
| NCI-H1648 | Afuresertib | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | AGI-5198 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | AGI-6780 | GDSC1 | 0.0020 | 0.5120 |
|
| NCI-H1648 | AGK-2 | GDSC2 | 0.0040 | 4.0000 |
|
| NCI-H1648 | AICA Ribonucleotide | GDSC1 | 7.8125 | 2000.0000 |
|
| NCI-H1648 | AKT inhibitor VIII | GDSC1 | 0.0100 | 10.2400 |
|
| NCI-H1648 | Alectinib | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | Alisertib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Alpelisib | GDSC2 | 0.0050 | 5.0000 |
|
| NCI-H1648 | alpha-lipoic acid | GDSC2 | 0.1211 | 121.0000 |
|
| NCI-H1648 | AMG-319 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Amuvatinib | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Apitolisib | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | AR-42 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | Ara-G | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | ARRY-520 | GDSC1 | 0.0010 | 0.2560 |
|
| NCI-H1648 | AS601245 | GDSC1 | 0.0312 | 8.0000 |
|
| NCI-H1648 | AS605240 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | ascorbate (vitamin C) | GDSC2 | 2.0011 | 2000.0000 |
|
| NCI-H1648 | AST-1306 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | AT-7519 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | AT13148 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | AT7867 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Avagacestat | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Axitinib | GDSC1,GDSC2 | 0.0078 | 10.0000 |
|
| NCI-H1648 | AZ20 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZ6102 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | AZ628 | GDSC1 | 0.0156 | 4.0000 |
|
| NCI-H1648 | AZD1208 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD1332 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD1480 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | AZD2014 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD3514 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD3759 | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | AZD4547 | GDSC1,GDSC2 | 0.0010 | 10.0000 |
|
| NCI-H1648 | AZD4877 | GDSC1 | 0.0002 | 0.6250 |
|
| NCI-H1648 | AZD5363 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | AZD5438 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD5582 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD6094 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | AZD6482 | GDSC1 | 0.0195 | 5.1200 |
|
| NCI-H1648 | AZD6738 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | AZD7762 | GDSC1,GDSC2 | 0.0078 | 10.0000 |
|
| NCI-H1648 | AZD7969 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD8055 | GDSC1,GDSC2 | 0.0020 | 2.0000 |
|
| NCI-H1648 | AZD8186 | GDSC1,GDSC2 | 0.0098 | 10.0000 |
|
| NCI-H1648 | AZD8835 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | AZD8931 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | BAM7 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | BAY ACCi | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | BAY AKT1 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | BAY-61-3606 | GDSC1 | 0.0312 | 8.0000 |
|
| NCI-H1648 | BAY-HDAC11_1 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | BAY-HDAC11_2 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | BAY-HDAC11_4 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | BAY-MPS-combo 2 (paclitaxel 1 uM) | GDSC1 | 0.0039 | 1.0000 |
|
| NCI-H1648 | BAY-MPS-combo-1 (paclitaxel 5 uM) | GDSC1 | 0.0039 | 1.0000 |
|
| NCI-H1648 | BAY-MPS1 | GDSC1 | 0.0117 | 3.0000 |
|
| NCI-H1648 | BDP-00009066 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Belinostat | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Bexarotene | GDSC1 | 0.0312 | 8.0000 |
|
| NCI-H1648 | BI-2536 | GDSC1,GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | BIBF-1120 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | BIBR-1532 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Bicalutamide | GDSC1 | 0.0040 | 10.0000 |
|
| NCI-H1648 | BIX02189 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Bleomycin | GDSC1 | 0.2500 | 64.0000 |
|
| NCI-H1648 | Bleomycin (10 uM) | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Bleomycin (50 uM) | GDSC1,GDSC2 | 0.0400 | 50.0000 |
|
| NCI-H1648 | BMS-345541 | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | BMS-509744 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | BMS-536924 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | BMS-754807 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Bortezomib | GDSC1,GDSC2 | 0.0000 | 0.0200 |
|
| NCI-H1648 | Bosutinib | GDSC1,GDSC2 | 0.0020 | 2.0000 |
|
| NCI-H1648 | BPD-00008900 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | BPTES | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Brivanib, BMS-540215 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Bryostatin 1 | GDSC1 | 0.0000 | 0.0080 |
|
| NCI-H1648 | Buparlisib | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | BX-912 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | BX795 | GDSC1 | 0.0195 | 5.0000 |
|
| NCI-H1648 | C-75 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Cabozantinib | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | Camptothecin | GDSC2 | 0.0001 | 0.1000 |
|
| NCI-H1648 | CAP-232, TT-232, TLN-232 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Capivasertib | GDSC1 | 0.1172 | 30.0000 |
|
| NCI-H1648 | CAY10566 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | CAY10603 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | CCT-018159 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | CCT007093 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | CCT245232 | GDSC1 | 0.0008 | 0.2000 |
|
| NCI-H1648 | CCT245467 | GDSC1 | 0.0008 | 0.2000 |
|
| NCI-H1648 | CD532 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | Cediranib | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Cetuximab | GDSC1 | 0.2570 | 65.8000 |
|
| NCI-H1648 | CGP-082996 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | CGP-60474 | GDSC1 | 0.0010 | 0.2560 |
|
| NCI-H1648 | CHIR-99021 | GDSC1 | 0.0100 | 10.0000 |
|
| NCI-H1648 | CI-1033 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | CI-1040 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Cisplatin | GDSC1,GDSC2 | 0.0040 | 10.0000 |
|
| NCI-H1648 | CMK | GDSC1 | 0.0156 | 4.0000 |
|
| NCI-H1648 | CP466722 | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | CP724714 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | CPI-613 | GDSC1 | 1.0000 | 256.0000 |
|
| NCI-H1648 | CPI-637 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Crizotinib | GDSC1,GDSC2,CCLE | 0.0025 | 10.0000 |
|
| NCI-H1648 | CRT0105446 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | CRT0105950 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | CRT0160829 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | CT7033-2 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | CUDC-101 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | CX-5461 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | Cyclopamine | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | Cyclophosphamide | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Cytarabine | GDSC1,GDSC2 | 0.0020 | 2.0000 |
|
| NCI-H1648 | Dabrafenib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Dacinostat | GDSC1 | 0.0040 | 1.0240 |
|
| NCI-H1648 | Dactinomycin | GDSC2 | 0.0008 | 0.8000 |
|
| NCI-H1648 | Dactolisib | GDSC1,GDSC2 | 0.0003 | 2.0000 |
|
| NCI-H1648 | Daporinad | GDSC1,GDSC2 | 0.0001 | 1.0000 |
|
| NCI-H1648 | Dasatinib | GDSC1,GDSC2 | 0.0010 | 2.0000 |
|
| NCI-H1648 | DMOG | GDSC1 | 15.6250 | 4000.0000 |
|
| NCI-H1648 | Docetaxel | GDSC1,GDSC2 | 0.0000 | 0.0125 |
|
| NCI-H1648 | Doramapimod | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Doxorubicin | GDSC1 | 0.0040 | 5.0000 |
|
| NCI-H1648 | Dyrk1b_0191 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | eEF2K Inhibitor, A-484954 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | EHT-1864 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Elesclomol | GDSC1 | 0.0008 | 0.2000 |
|
| NCI-H1648 | Embelin | GDSC1 | 0.1250 | 32.0000 |
|
| NCI-H1648 | Entinostat | GDSC1 | 0.0195 | 5.0000 |
|
| NCI-H1648 | Enzastaurin | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | EphB4_9721 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Epirubicin | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | Epothilone B | GDSC1 | 0.0001 | 0.0320 |
|
| NCI-H1648 | EPZ004777 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | EPZ5676 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Erlotinib | GDSC1,GDSC2,CCLE | 0.0020 | 8.0000 |
|
| NCI-H1648 | Etoposide | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | ETP-45835 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Fedratinib | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | FEN1_3940 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | FGFR_0939 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | FGFR_3831 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | FH535 | GDSC1 | 0.1250 | 32.0000 |
|
| NCI-H1648 | Flavopiridol | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | FMK | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Foretinib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | FR-180204 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | FS106 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | FS112 | GDSC1 | 0.0195 | 5.0000 |
|
| NCI-H1648 | FTI-277 | GDSC1 | 0.0040 | 1.0240 |
|
| NCI-H1648 | FTY-720 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Fulvestrant | GDSC1,GDSC2 | 0.0010 | 10.0000 |
|
| NCI-H1648 | FY012 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | FY026 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | FY069 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | GDC0810 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Gefitinib | GDSC1,GDSC2 | 0.0020 | 2.0000 |
|
| NCI-H1648 | Gemcitabine | GDSC1,GDSC2 | 0.0001 | 10.0000 |
|
| NCI-H1648 | Genentech Cpd 10 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | glutathione | GDSC2 | 0.6403 | 640.0000 |
|
| NCI-H1648 | GNE-317 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | GNF-2 | GDSC1 | 0.0050 | 1.2800 |
|
| NCI-H1648 | GSK-J4 | GDSC1 | 0.1172 | 30.0000 |
|
| NCI-H1648 | GSK-LSD1-2HCl | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | GSK1059615 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | GSK1070916 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | GSK1904529A | GDSC1,GDSC2 | 0.0040 | 10.0000 |
|
| NCI-H1648 | GSK2578215A | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | GSK269962A | GDSC1 | 0.0098 | 5.0000 |
|
| NCI-H1648 | GSK2830371 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | GSK319347A | GDSC1 | 0.0195 | 5.0000 |
|
| NCI-H1648 | GSK343 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | GSK429286A | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | GSK591 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | GSK650394 | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | GSK690693 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | GW-2580 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | GW441756 | GDSC1,GDSC2 | 0.0020 | 2.0000 |
|
| NCI-H1648 | GW843682X | GDSC1 | 0.0010 | 0.2560 |
|
| NCI-H1648 | HG-5-113-01 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | HG-5-88-01 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | HG-6-71-01 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | HG6-64-1 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | HKMTI-1-005 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | I-BET-762 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | I-BET151 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | I-BRD9 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | I-CBP112 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | IAP_5620 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | IAP_7638 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | IC-87114 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | ICL-SIRT078 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | ICL1100013 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Idelalisib | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | IGFR_3801 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Imatinib | GDSC1 | 0.0078 | 2.0000 |
|
| NCI-H1648 | IMD-0354 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | IOX2 | GDSC1 | 0.0004 | 0.1000 |
|
| NCI-H1648 | IPA-3 | GDSC1 | 0.1250 | 32.0000 |
|
| NCI-H1648 | Ipatasertib | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Irinotecan | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Ispinesib Mesylate | GDSC1 | 0.0005 | 0.1280 |
|
| NCI-H1648 | JAK1_3715 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | JAK3_7406 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | JNJ38877605 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | JNK Inhibitor VIII | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | JNK-9L | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | JQ1 | GDSC1,GDSC2 | 0.0039 | 10.0000 |
|
| NCI-H1648 | JQ12 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | JW-7-24-1 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | JW-7-52-1 | GDSC1 | 0.0047 | 1.2000 |
|
| NCI-H1648 | kb NB 142-70 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | KIN001-042 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | KIN001-236 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | KIN001-244 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | KIN001-260 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | KIN001-266 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | KIN001-270 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Kobe2602 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | KU-55933 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | KU-60019 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | L-685458 | CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | Lapatinib | GDSC1,GDSC2,CCLE | 0.0025 | 10.0000 |
|
| NCI-H1648 | LBW242 | CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | LCL161 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | LDN-193189 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | Lenalidomide | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Lestaurtinib | GDSC1,GDSC2 | 0.0020 | 2.0000 |
|
| NCI-H1648 | LFM-A13 | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | LGK974 | GDSC1,GDSC2 | 0.0050 | 10.0000 |
|
| NCI-H1648 | LIMK1 inhibitor BMS4 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Linifanib | GDSC1 | 0.0040 | 1.0240 |
|
| NCI-H1648 | Linsitinib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | LJI308 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Luminespib | GDSC1,GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | Masitinib | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | MCT1_6447 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | MCT4_1422 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | MetAP2 Inhibitor, A832234 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | Methotrexate | GDSC1,GDSC2 | 0.0008 | 1.0000 |
|
| NCI-H1648 | MG-132 | GDSC1,GDSC2 | 0.0039 | 4.0000 |
|
| NCI-H1648 | Midostaurin | GDSC1 | 0.0020 | 0.5120 |
|
| NCI-H1648 | MIM1 | GDSC1,GDSC2 | 0.0100 | 40.0000 |
|
| NCI-H1648 | MIRA-1 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Mirin | GDSC1 | 0.3906 | 100.0000 |
|
| NCI-H1648 | Mitomycin-C | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | MK-1775 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | MK-2206 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | MK-8776 | GDSC2 | 0.0050 | 5.0000 |
|
| NCI-H1648 | Motesanib | GDSC1,GDSC2 | 0.0078 | 10.0000 |
|
| NCI-H1648 | MPS-1-IN-1 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Mycophenolic acid | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | N-acetyl cysteine | GDSC2 | 2.0011 | 2000.0000 |
|
| NCI-H1648 | N22899-6-C1 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | N23918-95-7 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | N24798-49-A1 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | N25720-51-A1 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | N27922-53-1 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | N29087-69-1 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | N30652-18-1 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Navitoclax | GDSC1,GDSC2 | 0.0020 | 10.0000 |
|
| NCI-H1648 | NG-25 | GDSC1 | 0.0391 | 10.2400 |
|
| NCI-H1648 | Nilotinib | GDSC1,GDSC2,CCLE | 0.0020 | 8.0000 |
|
| NCI-H1648 | NPK76-II-72-1 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | NSC-207895 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | NSC-87877 | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | NSC319726 | GDSC1 | 0.0010 | 0.2560 |
|
| NCI-H1648 | NU7441 | GDSC1,GDSC2 | 0.0078 | 10.0000 |
|
| NCI-H1648 | Nutlin-3a | GDSC1,GDSC2,CCLE | 0.0025 | 10.0000 |
|
| NCI-H1648 | NVP-ADW742 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | NVP-BHG712 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | NVP-TAE684 | GDSC1,CCLE | 0.0078 | 8.0000 |
|
| NCI-H1648 | Obatoclax Mesylate | GDSC1,GDSC2 | 0.0100 | 16.0000 |
|
| NCI-H1648 | Olaparib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Omipalisib | GDSC1 | 0.0040 | 1.0240 |
|
| NCI-H1648 | OSI-027 | GDSC1,GDSC2 | 0.0040 | 20.0000 |
|
| NCI-H1648 | OSI-930 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | Osimertinib | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | OSU-03012 | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | Oxaliplatin | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | P22077 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | PAC-1 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | Paclitaxel | GDSC1,GDSC2,CCLE | 0.0000 | 8.0000 |
|
| NCI-H1648 | Palbociclib | GDSC2,CCLE | 0.0025 | 10.0000 |
|
| NCI-H1648 | Panobinostat | GDSC1,CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | PARP_0108 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | PARP_9482 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | PARP_9495 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | Parthenolide | GDSC1 | 0.0195 | 5.0000 |
|
| NCI-H1648 | Pazopanib | GDSC1 | 0.0312 | 8.0000 |
|
| NCI-H1648 | PBD-288 | GDSC2 | 0.0050 | 5.0000 |
|
| NCI-H1648 | PD0325901 | GDSC1,GDSC2,CCLE | 0.0003 | 8.0000 |
|
| NCI-H1648 | PD173074 | GDSC1,GDSC2 | 0.0020 | 10.0000 |
|
| NCI-H1648 | Pelitinib | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Pemetrexed | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | Pevonedistat | GDSC1,GDSC2 | 0.0039 | 10.0000 |
|
| NCI-H1648 | PF-00299804 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | PF-4708671 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | PF-562271 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | PFI-1 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | PFI3 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | PHA-665752 | GDSC1,CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | PHA-793887 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | Phenformin | GDSC1 | 15.6250 | 4000.0000 |
|
| NCI-H1648 | PI-103 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | PI3Ka_4409 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Pictilisib | GDSC1,GDSC2 | 0.0040 | 10.0000 |
|
| NCI-H1648 | PIK-93 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Pilaralisib | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Piperlongumine | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | PLK_6522 | GDSC1 | 0.0024 | 0.6250 |
|
| NCI-H1648 | PLX-4720 | GDSC1,GDSC2,CCLE | 0.0025 | 10.0000 |
|
| NCI-H1648 | POMHEX | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Ponatinib | GDSC1 | 0.0020 | 0.5120 |
|
| NCI-H1648 | Pyridostatin | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Pyrimethamine | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | QL-VIII-58 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | QL-X-138 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | QL-XI-92 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | QL-XII-47 | GDSC1 | 0.0391 | 10.2400 |
|
| NCI-H1648 | QL-XII-61 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | QS11 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | Quizartinib | GDSC1 | 0.0040 | 1.0240 |
|
| NCI-H1648 | RAF_9304 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | RAF265 | CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | Rapamycin | GDSC1,GDSC2 | 0.0000 | 0.1000 |
|
| NCI-H1648 | Refametinib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Ribociclib | GDSC2 | 0.0020 | 2.0000 |
|
| NCI-H1648 | RO-3306 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | rTRAIL | GDSC1 | 0.0004 | 0.1000 |
|
| NCI-H1648 | RU-SKI 43 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Rucaparib | GDSC1,GDSC2 | 0.0050 | 5.0000 |
|
| NCI-H1648 | Ruxolitinib | GDSC1 | 0.0205 | 5.2400 |
|
| NCI-H1648 | S-Trityl-L-cysteine | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | Salubrinal | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | Sapitinib | GDSC2 | 0.0050 | 10.0000 |
|
| NCI-H1648 | Saracatinib | GDSC1,CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | Savolitinib | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | SB216763 | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | SB505124 | GDSC1 | 0.0391 | 20.0000 |
|
| NCI-H1648 | SB52334 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | SB590885 | GDSC2 | 0.0050 | 5.0000 |
|
| NCI-H1648 | SCH772984 | GDSC2 | 0.0050 | 5.0000 |
|
| NCI-H1648 | Seliciclib | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | Selisistat | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Selumetinib | GDSC1,GDSC2,CCLE | 0.0025 | 10.0000 |
|
| NCI-H1648 | Sepantronium bromide | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Serdemetan | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | SGC0946 | GDSC1,GDSC2 | 0.0005 | 0.5000 |
|
| NCI-H1648 | Shikonin | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | SL0101 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | SN-38 | GDSC1,GDSC2 | 0.0000 | 0.1000 |
|
| NCI-H1648 | SNX-2112 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | Sorafenib | GDSC1,GDSC2,CCLE | 0.0025 | 10.0000 |
|
| NCI-H1648 | Sphingosine Kinase 1 Inhibitor II | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | Staurosporine | GDSC2 | 0.0078 | 2.0000 |
|
| NCI-H1648 | STF-62247 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | SU11274 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | Sunitinib | GDSC1 | 0.0312 | 8.0000 |
|
| NCI-H1648 | T0901317 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | TAK-715 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Talazoparib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Tamoxifen | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Tanespimycin | GDSC1,GDSC2,CCLE | 0.0010 | 8.0000 |
|
| NCI-H1648 | TANK_1366 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | Taselisib | GDSC2 | 0.0050 | 10.0000 |
|
| NCI-H1648 | Telomerase Inhibitor IX | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Temozolomide | GDSC1,GDSC2 | 0.0300 | 30.0000 |
|
| NCI-H1648 | Temsirolimus | GDSC1,GDSC2 | 0.0008 | 1.0000 |
|
| NCI-H1648 | Tenovin-6 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | TGX221 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Thapsigargin | GDSC1 | 0.0020 | 0.5120 |
|
| NCI-H1648 | THR-101 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | THR-102 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | THR-103 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | THZ-1-87 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | THZ-2-102-1 | GDSC1 | 0.0098 | 2.5000 |
|
| NCI-H1648 | THZ-2-49 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | THZ-2-98-01 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Tipifarnib | GDSC1 | 0.0625 | 16.0000 |
|
| NCI-H1648 | Tivozanib | GDSC1 | 0.0005 | 0.1280 |
|
| NCI-H1648 | TKI258 | CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | TL-1-85 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | TL-2-105 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | Topotecan | CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | Torin 2 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | torin2 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Tozasertib | GDSC1 | 0.0078 | 2.0000 |
|
| NCI-H1648 | TPCA-1 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Trametinib | GDSC1,GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | Tretinoin | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Trichostatin A | GDSC1 | 0.0040 | 1.0240 |
|
| NCI-H1648 | TTK_3146 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Tubastatin A | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | TW 37 | GDSC1,GDSC2 | 0.0050 | 5.0000 |
|
| NCI-H1648 | TWS119 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | Ulixertinib | GDSC2 | 0.0020 | 10.0000 |
|
| NCI-H1648 | UMI-77 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | UNC0379 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | UNC0638 | GDSC1,GDSC2 | 0.0050 | 40.0000 |
|
| NCI-H1648 | UNC0642 | GDSC1 | 0.0020 | 0.5000 |
|
| NCI-H1648 | UNC1215 | GDSC1 | 0.0039 | 1.0000 |
|
| NCI-H1648 | Uprosertib | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | VE821 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Veliparib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Venetoclax | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | Venotoclax | GDSC1 | 0.0010 | 0.2560 |
|
| NCI-H1648 | Vinblastine | GDSC1,GDSC2 | 0.0001 | 0.1000 |
|
| NCI-H1648 | Vinorelbine | GDSC1,GDSC2 | 0.0001 | 0.1000 |
|
| NCI-H1648 | Vismodegib | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | VNLG-124 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | Vorinostat | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Voxtalisib | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | VTP-A | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | VTP-B | GDSC2 | 0.0010 | 1.0000 |
|
| NCI-H1648 | VX-11e | GDSC1,GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | VX-702 | GDSC1 | 0.0078 | 2.0000 |
|
| NCI-H1648 | Wee1 Inhibitor | GDSC1,GDSC2 | 0.0078 | 10.0000 |
|
| NCI-H1648 | WEHI-539 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | WH-4-023 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | WHI-P97 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | WIKI4 | GDSC2 | 0.0100 | 10.0000 |
|
| NCI-H1648 | Wnt-C59 | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | WYE-125132 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | WZ-1-84 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | WZ3105 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | XAV939 | GDSC1 | 0.0195 | 5.0000 |
|
| NCI-H1648 | XMD11-50 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | XMD11-85h | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | XMD13-2 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | XMD14-99 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | XMD15-27 | GDSC1 | 0.0400 | 10.2400 |
|
| NCI-H1648 | XMD8-85 | GDSC1 | 0.0312 | 8.0000 |
|
| NCI-H1648 | XMD8-92 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Y-39983 | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | YK-4-279 | GDSC1,GDSC2 | 0.0200 | 20.0000 |
|
| NCI-H1648 | YM201636 | GDSC1 | 0.0200 | 5.1200 |
|
| NCI-H1648 | Z-LLNle-CHO | GDSC1 | 0.0100 | 2.5600 |
|
| NCI-H1648 | ZD-6474 | CCLE | 0.0025 | 8.0000 |
|
| NCI-H1648 | ZG-10 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | Zibotentan | GDSC1 | 0.0781 | 20.0000 |
|
| NCI-H1648 | ZL049 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | ZL109 | GDSC1 | 0.0391 | 10.0000 |
|
| NCI-H1648 | ZM447439 | GDSC1,GDSC2 | 0.0078 | 10.0000 |
|
| NCI-H1648 | ZSTK474 | GDSC1 | 0.0200 | 5.1200 |
|
IC50
IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.
Drugs with highest and lowest IC50
Drugs with highest and lowest IC50
IC90
IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.
Drugs with highest and lowest IC90
Drugs with highest and lowest IC90
AUC
AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.
Drugs with highest and lowest AUC
Drugs with highest and lowest AUC