Drug : Torin2

GDSC1 Name : torin2

Dataset : All
Synonyms :
Targets : MTOR, ATM, ATR, DNAPK
Pathways : PI3K/MTOR signaling

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
torin2 K5 GDSC1 0.0391 10.0000
torin2 D-336MG GDSC1 0.0391 10.0000
torin2 PC-14 GDSC1 0.0391 10.0000
torin2 U2OS GDSC1 0.0391 10.0000
torin2 NCI-H1648 GDSC1 0.0391 10.0000
torin2 UACC-893 GDSC1 0.0391 10.0000
torin2 NCI-H2810 GDSC1 0.0391 10.0000
torin2 SK-MEL-28 GDSC1 0.0391 10.0000
torin2 COLO829 GDSC1 0.0391 10.0000
torin2 A-375 GDSC1 0.0391 10.0000
torin2 LB996-RCC GDSC1 0.0391 10.0000
torin2 NCI-H2122 GDSC1 0.0391 10.0000
torin2 ZR-75-30 GDSC1 0.0391 10.0000
torin2 NCI-H2803 GDSC1 0.0391 10.0000
torin2 NCI-H1437 GDSC1 0.0391 10.0000
torin2 SW620 GDSC1 0.0391 10.0000
torin2 DOTC24510 GDSC1 0.0391 10.0000
torin2 SK-N-AS GDSC1 0.0391 10.0000
torin2 NCI-H2804 GDSC1 0.0391 10.0000
torin2 CAL-27 GDSC1 0.0391 10.0000
torin2 DOK GDSC1 0.0391 10.0000
torin2 HUP-T3 GDSC1 0.0391 10.0000
torin2 CAL-62 GDSC1 0.0391 10.0000
torin2 C2BBE1 GDSC1 0.0391 10.0000
torin2 SNU-C2B GDSC1 0.0391 10.0000
torin2 IST-MES1 GDSC1 0.0391 10.0000
torin2 LOX-IMVI GDSC1 0.0391 10.0000
torin2 GP5D GDSC1 0.0391 10.0000
torin2 KM12 GDSC1 0.0391 10.0000
torin2 NCI-N87 GDSC1 0.0391 10.0000
torin2 ESS-1 GDSC1 0.0391 10.0000
torin2 CHP-212 GDSC1 0.0391 10.0000
torin2 KYSE-220 GDSC1 0.0391 10.0000
torin2 LNCAPCLONEFGC GDSC1 0.0391 10.0000
torin2 MHH-ES-1 GDSC1 0.0391 10.0000
torin2 SJSA-1 GDSC1 0.0391 10.0000
torin2 ES6 GDSC1 0.0391 10.0000
torin2 KU-19-19 GDSC1 0.0391 10.0000
torin2 TK-10 GDSC1 0.0391 10.0000
torin2 LOVO GDSC1 0.0391 10.0000
torin2 M059J GDSC1 0.0391 10.0000
torin2 D-247MG GDSC1 0.0391 10.0000
torin2 SF268 GDSC1 0.0391 10.0000
torin2 SF126 GDSC1 0.0391 10.0000
torin2 RL95-2 GDSC1 0.0391 10.0000
torin2 CGTH-W-1 GDSC1 0.0391 10.0000
torin2 NCI-H2087 GDSC1 0.0391 10.0000
torin2 SJNB-6 GDSC1 0.0391 10.0000
torin2 TGBC1TKB GDSC1 0.0391 10.0000
torin2 ES8 GDSC1 0.0391 10.0000
torin2 SW1783 GDSC1 0.0391 10.0000
torin2 EW-24 GDSC1 0.0391 10.0000
torin2 LB771-HNC GDSC1 0.0391 10.0000
torin2 LS180 GDSC1 0.0391 10.0000
torin2 SW48 GDSC1 0.0391 10.0000
torin2 NCI-H292 GDSC1 0.0391 10.0000
torin2 NCI-H28 GDSC1 0.0391 10.0000
torin2 NCI-H226 GDSC1 0.0391 10.0000
torin2 CAL-33 GDSC1 0.0391 10.0000
torin2 CW-2 GDSC1 0.0391 10.0000
torin2 HCT116 GDSC1 0.0391 10.0000
torin2 MDST8 GDSC1 0.0391 10.0000
torin2 BT-474 GDSC1 0.0391 10.0000
torin2 MZ-MEL-2 GDSC1 0.0391 10.0000
torin2 T84 GDSC1 0.0391 10.0000
torin2 KURAMOCHI GDSC1 0.0391 10.0000
torin2 A-388 GDSC1 0.0391 10.0000
torin2 DBTRG-05MG GDSC1 0.0391 10.0000
torin2 MFM-223 GDSC1 0.0391 10.0000
torin2 SJNB-14 GDSC1 0.0391 10.0000
torin2 LB831-BLC GDSC1 0.0391 10.0000
torin2 VMRC-MELG GDSC1 0.0391 10.0000
torin2 ES1 GDSC1 0.0391 10.0000
torin2 SW948 GDSC1 0.0391 10.0000
torin2 SNU-387 GDSC1 0.0391 10.0000
torin2 DMS273 GDSC1 0.0391 10.0000
torin2 A-549 GDSC1 0.0391 10.0000
torin2 A101D GDSC1 0.0391 10.0000
torin2 BE-13 GDSC1 0.0391 10.0000
torin2 EOL-1 GDSC1 0.0391 10.0000
torin2 LB1047-RCC GDSC1 0.0391 10.0000
torin2 LB647-SCLC GDSC1 0.0391 10.0000
torin2 LXF289 GDSC1 0.0391 10.0000
torin2 SK-MM-2 GDSC1 0.0391 10.0000
torin2 VAL GDSC1 0.0391 10.0000
torin2 SK-MEL-2 GDSC1 0.0391 10.0000
torin2 SW626 GDSC1 0.0391 10.0000
torin2 VMRC-RCZ GDSC1 0.0391 10.0000
torin2 8505C GDSC1 0.0391 10.0000
torin2 SF295 GDSC1 0.0391 10.0000
torin2 C32[HUMANMELANOMA] GDSC1 0.0391 10.0000
torin2 CP50-MEL-B GDSC1 0.0391 10.0000
torin2 HT-55 GDSC1 0.0391 10.0000
torin2 MDA-MB-415 GDSC1 0.0391 10.0000
torin2 CAR-1 GDSC1 0.0391 10.0000
torin2 HCT15 GDSC1 0.0391 10.0000
torin2 C-4-I GDSC1 0.0391 10.0000
torin2 TYK-NU GDSC1 0.0391 10.0000
torin2 SW1573 GDSC1 0.0391 10.0000
torin2 HT-29 GDSC1 0.0391 10.0000
torin2 OV-90 GDSC1 0.0391 10.0000
torin2 RCM-1[HUMANESC] GDSC1 0.0391 10.0000
torin2 PL4 GDSC1 0.0391 10.0000
torin2 OVKATE GDSC1 0.0391 10.0000
torin2 D-423MG GDSC1 0.0391 10.0000
torin2 KP-N-YN GDSC1 0.0391 10.0000
torin2 ABC-1 GDSC1 0.0391 10.0000
torin2 NCI-H2795 GDSC1 0.0391 10.0000
torin2 HSC-4 GDSC1 0.0391 10.0000
torin2 LC-1-SQ GDSC1 0.0391 10.0000
torin2 TMK-1 GDSC1 0.0391 10.0000
torin2 NCI-H1563 GDSC1 0.0391 10.0000
torin2 TOV-112D GDSC1 0.0391 10.0000
torin2 HCC15 GDSC1 0.0391 10.0000
torin2 D-566MG GDSC1 0.0391 10.0000
torin2 HT115 GDSC1 0.0391 10.0000
torin2 GRANTA-519 GDSC1 0.0391 10.0000
torin2 CL-11 GDSC1 0.0391 10.0000
torin2 WIL2NS GDSC1 0.0391 10.0000
torin2 SKN GDSC1 0.0391 10.0000
torin2 KTCTL-140 GDSC1 0.0391 10.0000
torin2 DOV13 GDSC1 0.0391 10.0000
torin2 KTCTL-1M GDSC1 0.0391 10.0000
torin2 KTCTL-26A GDSC1 0.0391 10.0000
torin2 FLO-1 GDSC1 0.0391 10.0000
torin2 HEY GDSC1 0.0391 10.0000
torin2 TE-4 GDSC1 0.0391 10.0000
torin2 JHOS-2 GDSC1 0.0391 10.0000
torin2 ACC-OV7 GDSC1 0.0391 10.0000
torin2 KTCTL-13 GDSC1 0.0391 10.0000
torin2 KATOIII GDSC1 0.0391 10.0000

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.