Drug : Xmd11-50

GDSC1 Name : XMD11-50

Dataset : All
Synonyms :
Targets : LRRK2, ERK5
Pathways : Other, kinases

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
XMD11-50 PC-14 GDSC1 0.0391 10.0000
XMD11-50 NCI-H1648 GDSC1 0.0391 10.0000
XMD11-50 UACC-893 GDSC1 0.0391 10.0000
XMD11-50 NCI-H2810 GDSC1 0.0391 10.0000
XMD11-50 MKN28 GDSC1 0.0391 10.0000
XMD11-50 COLO829 GDSC1 0.0391 10.0000
XMD11-50 A-375 GDSC1 0.0391 10.0000
XMD11-50 A2058 GDSC1 0.0391 10.0000
XMD11-50 ZR-75-30 GDSC1 0.0391 10.0000
XMD11-50 NCI-H2803 GDSC1 0.0391 10.0000
XMD11-50 NCI-H1437 GDSC1 0.0391 10.0000
XMD11-50 SW620 GDSC1 0.0391 10.0000
XMD11-50 CAPAN-1 GDSC1 0.0391 10.0000
XMD11-50 DOTC24510 GDSC1 0.0391 10.0000
XMD11-50 SK-N-AS GDSC1 0.0391 10.0000
XMD11-50 NCI-H2804 GDSC1 0.0391 10.0000
XMD11-50 DOK GDSC1 0.0391 10.0000
XMD11-50 HUP-T3 GDSC1 0.0391 10.0000
XMD11-50 CAL-62 GDSC1 0.0391 10.0000
XMD11-50 C2BBE1 GDSC1 0.0391 10.0000
XMD11-50 SNU-C2B GDSC1 0.0391 10.0000
XMD11-50 IST-MES1 GDSC1 0.0391 10.0000
XMD11-50 LOX-IMVI GDSC1 0.0391 10.0000
XMD11-50 GP5D GDSC1 0.0391 10.0000
XMD11-50 FADU GDSC1 0.0391 10.0000
XMD11-50 NCI-N87 GDSC1 0.0391 10.0000
XMD11-50 ESS-1 GDSC1 0.0391 10.0000
XMD11-50 AU565 GDSC1 0.0391 10.0000
XMD11-50 CHP-212 GDSC1 0.0391 10.0000
XMD11-50 RPMI-7951 GDSC1 0.0391 10.0000
XMD11-50 NB69 GDSC1 0.0391 10.0000
XMD11-50 MHH-ES-1 GDSC1 0.0391 10.0000
XMD11-50 KU-19-19 GDSC1 0.0391 10.0000
XMD11-50 MSTO-211H GDSC1 0.0391 10.0000
XMD11-50 LOVO GDSC1 0.0391 10.0000
XMD11-50 PFSK-1 GDSC1 0.0391 10.0000
XMD11-50 M059J GDSC1 0.0391 10.0000
XMD11-50 D-247MG GDSC1 0.0391 10.0000
XMD11-50 CGTH-W-1 GDSC1 0.0391 10.0000
XMD11-50 SW1783 GDSC1 0.0391 10.0000
XMD11-50 EW-24 GDSC1 0.0391 10.0000
XMD11-50 LS180 GDSC1 0.0391 10.0000
XMD11-50 SW48 GDSC1 0.0391 10.0000
XMD11-50 NCI-H28 GDSC1 0.0391 10.0000
XMD11-50 CAL-33 GDSC1 0.0391 10.0000
XMD11-50 CW-2 GDSC1 0.0391 10.0000
XMD11-50 HCT116 GDSC1 0.0391 10.0000
XMD11-50 MDST8 GDSC1 0.0391 10.0000
XMD11-50 BT-474 GDSC1 0.0391 10.0000
XMD11-50 A-388 GDSC1 0.0391 10.0000
XMD11-50 DBTRG-05MG GDSC1 0.0391 10.0000
XMD11-50 KYSE-140 GDSC1 0.0391 10.0000
XMD11-50 MFM-223 GDSC1 0.0391 10.0000
XMD11-50 SJNB-14 GDSC1 0.0391 10.0000
XMD11-50 KYSE-410 GDSC1 0.0391 10.0000
XMD11-50 AGS GDSC1 0.0391 10.0000
XMD11-50 VMRC-MELG GDSC1 0.0391 10.0000
XMD11-50 SW948 GDSC1 0.0391 10.0000
XMD11-50 SNU-387 GDSC1 0.0391 10.0000
XMD11-50 IGR-1 GDSC1 0.0391 10.0000
XMD11-50 DMS273 GDSC1 0.0391 10.0000
XMD11-50 A-549 GDSC1 0.0391 10.0000
XMD11-50 BE-13 GDSC1 0.0391 10.0000
XMD11-50 EOL-1 GDSC1 0.0391 10.0000
XMD11-50 LB647-SCLC GDSC1 0.0391 10.0000
XMD11-50 NCI-H716 GDSC1 0.0391 10.0000
XMD11-50 SK-MM-2 GDSC1 0.0391 10.0000
XMD11-50 SNU-C1 GDSC1 0.0391 10.0000
XMD11-50 VAL GDSC1 0.0391 10.0000
XMD11-50 SK-MEL-2 GDSC1 0.0391 10.0000
XMD11-50 SNU-16 GDSC1 0.0391 10.0000
XMD11-50 HCC2218 GDSC1 0.0391 10.0000
XMD11-50 HUP-T4 GDSC1 0.0391 10.0000
XMD11-50 HCC2157 GDSC1 0.0391 10.0000
XMD11-50 COLO684 GDSC1 0.0391 10.0000
XMD11-50 8505C GDSC1 0.0391 10.0000
XMD11-50 SBC-1 GDSC1 0.0391 10.0000
XMD11-50 C32[HUMANMELANOMA] GDSC1 0.0391 10.0000
XMD11-50 CP50-MEL-B GDSC1 0.0391 10.0000
XMD11-50 HT-55 GDSC1 0.0391 10.0000
XMD11-50 CAR-1 GDSC1 0.0391 10.0000
XMD11-50 HCT15 GDSC1 0.0391 10.0000
XMD11-50 C-4-I GDSC1 0.0391 10.0000
XMD11-50 LU-65 GDSC1 0.0391 10.0000
XMD11-50 HT-29 GDSC1 0.0391 10.0000
XMD11-50 OVKATE GDSC1 0.0391 10.0000
XMD11-50 D-423MG GDSC1 0.0391 10.0000
XMD11-50 NCI-H2795 GDSC1 0.0391 10.0000
XMD11-50 TGW GDSC1 0.0391 10.0000
XMD11-50 TMK-1 GDSC1 0.0391 10.0000
XMD11-50 D-566MG GDSC1 0.0391 10.0000
XMD11-50 HT115 GDSC1 0.0391 10.0000
XMD11-50 GRANTA-519 GDSC1 0.0391 10.0000
XMD11-50 WIL2NS GDSC1 0.0391 10.0000
XMD11-50 DOV13 GDSC1 0.0391 10.0000
XMD11-50 FLO-1 GDSC1 0.0391 10.0000
XMD11-50 HEY GDSC1 0.0391 10.0000
XMD11-50 KATOIII GDSC1 0.0391 10.0000
XMD11-50 OCI-LY7 GDSC1 0.0391 10.0000

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.