Cell Line : NCI-H835

Cellosaurus Index : CVCL_1593
Cellosaurus ID : NCI-H835

CCLE Name : NCIH835_LUNG
GDSC1 Name , GDSC2 Name : NCI-H835

Cancer Type : lung
Dataset : All

Drug Response Information

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Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including cell line name, drug name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Cellosaurus ID Drug Name Original Dataset(s) Min Dose Max Dose Dose-response
NCI-H835 (5Z)-7-Oxozeaenol GDSC1 0.0391 10.0000
NCI-H835 5-azacytidine GDSC2 0.0200 20.0000
NCI-H835 5-Fluorouracil GDSC2 0.0200 32.0000
NCI-H835 965-D2 GDSC1 0.0391 10.0000
NCI-H835 993-D2 GDSC1 0.0391 10.0000
NCI-H835 A-366 GDSC2 0.0100 10.0000
NCI-H835 ABT737 GDSC2 0.0100 10.0000
NCI-H835 ACY-1215 GDSC1 0.0781 20.0000
NCI-H835 Afatinib GDSC1,GDSC2 0.0020 10.0000
NCI-H835 Afuresertib GDSC2 0.0100 10.0000
NCI-H835 AGI-5198 GDSC2 0.0100 10.0000
NCI-H835 AGK-2 GDSC2 0.0040 4.0000
NCI-H835 AICA Ribonucleotide GDSC1 7.8125 2000.0000
NCI-H835 Alisertib GDSC2 0.0100 10.0000
NCI-H835 Alpelisib GDSC2 0.0050 5.0000
NCI-H835 AMG-319 GDSC2 0.0100 10.0000
NCI-H835 Apitolisib GDSC1 0.0781 20.0000
NCI-H835 ascorbate (vitamin C) GDSC2 2.0011 2000.0000
NCI-H835 AST-1306 GDSC1 0.0781 20.0000
NCI-H835 AT13148 GDSC2 0.0100 10.0000
NCI-H835 AT7867 GDSC1 0.0781 20.0000
NCI-H835 Avagacestat GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Axitinib GDSC1,GDSC2 0.0078 10.0000
NCI-H835 AZ20 GDSC1 0.0391 10.0000
NCI-H835 AZ6102 GDSC2 0.0100 10.0000
NCI-H835 AZD1208 GDSC1 0.0391 10.0000
NCI-H835 AZD1332 GDSC1 0.0391 10.0000
NCI-H835 AZD1480 GDSC1 0.0098 2.5000
NCI-H835 AZD2014 GDSC1 0.0391 10.0000
NCI-H835 AZD3514 GDSC1 0.0391 10.0000
NCI-H835 AZD3759 GDSC2 0.0010 1.0000
NCI-H835 AZD4547 GDSC1,GDSC2 0.0010 10.0000
NCI-H835 AZD4877 GDSC1 0.0002 0.0390
NCI-H835 AZD5363 GDSC2 0.0100 10.0000
NCI-H835 AZD5438 GDSC1 0.0391 10.0000
NCI-H835 AZD5582 GDSC1 0.0391 10.0000
NCI-H835 AZD6094 GDSC1 0.0098 2.5000
NCI-H835 AZD6482 GDSC1 0.0195 5.0000
NCI-H835 AZD6738 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 AZD7762 GDSC1,GDSC2 0.0078 10.0000
NCI-H835 AZD7969 GDSC1 0.0391 10.0000
NCI-H835 AZD8055 GDSC1,GDSC2 0.0020 2.0000
NCI-H835 AZD8186 GDSC1,GDSC2 0.0098 10.0000
NCI-H835 AZD8835 GDSC1 0.0391 10.0000
NCI-H835 AZD8931 GDSC1 0.0391 10.0000
NCI-H835 BAY ACCi GDSC1 0.0391 10.0000
NCI-H835 BAY AKT1 GDSC1 0.0391 10.0000
NCI-H835 BAY-HDAC11_1 GDSC1 0.0391 10.0000
NCI-H835 BAY-HDAC11_2 GDSC1 0.0391 10.0000
NCI-H835 BAY-HDAC11_4 GDSC1 0.0391 10.0000
NCI-H835 BAY-MPS-combo 2 (paclitaxel 1 uM) GDSC1 0.0039 1.0000
NCI-H835 BAY-MPS-combo-1 (paclitaxel 5 uM) GDSC1 0.0039 1.0000
NCI-H835 BAY-MPS1 GDSC1 0.0117 3.0000
NCI-H835 BDP-00009066 GDSC2 0.0100 10.0000
NCI-H835 BI-2536 GDSC2 0.0010 1.0000
NCI-H835 BIBF-1120 GDSC1 0.0781 20.0000
NCI-H835 BIBR-1532 GDSC2 0.0100 10.0000
NCI-H835 Bicalutamide GDSC1 0.0391 10.0000
NCI-H835 Bleomycin (10 uM) GDSC1 0.0391 10.0000
NCI-H835 Bleomycin (50 uM) GDSC1,GDSC2 0.0400 50.0000
NCI-H835 BMS-536924 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 BMS-754807 GDSC2 0.0100 10.0000
NCI-H835 Bortezomib GDSC2 0.0000 0.0200
NCI-H835 Bosutinib GDSC1,GDSC2 0.0020 2.0000
NCI-H835 BPD-00008900 GDSC2 0.0100 10.0000
NCI-H835 BPTES GDSC1 0.0391 10.0000
NCI-H835 Brivanib, BMS-540215 GDSC1 0.0781 20.0000
NCI-H835 Buparlisib GDSC2 0.0100 10.0000
NCI-H835 BX795 GDSC1 0.0195 5.0000
NCI-H835 Camptothecin GDSC2 0.0001 0.1000
NCI-H835 Capivasertib GDSC1 0.1172 30.0000
NCI-H835 CCT-018159 GDSC1 0.0391 10.0000
NCI-H835 CCT007093 GDSC1 0.0258 6.6000
NCI-H835 CCT245232 GDSC1 0.0008 0.2000
NCI-H835 CCT245467 GDSC1 0.0008 0.2000
NCI-H835 CD532 GDSC1 0.0200 5.1200
NCI-H835 Cediranib GDSC2 0.0100 10.0000
NCI-H835 Cetuximab GDSC1 0.2570 65.8000
NCI-H835 CHIR-99021 GDSC1 0.0391 10.0000
NCI-H835 CI-1033 GDSC1 0.0781 20.0000
NCI-H835 CI-1040 GDSC1 0.0391 10.0000
NCI-H835 Cisplatin GDSC1,GDSC2 0.0040 10.0000
NCI-H835 CPI-637 GDSC2 0.0100 10.0000
NCI-H835 Crizotinib GDSC2 0.0080 10.0000
NCI-H835 CRT0105446 GDSC1 0.0391 10.0000
NCI-H835 CRT0105950 GDSC1 0.0391 10.0000
NCI-H835 CRT0160829 GDSC1 0.0781 20.0000
NCI-H835 CT7033-2 GDSC2 0.0100 10.0000
NCI-H835 Cyclophosphamide GDSC2 0.0100 10.0000
NCI-H835 Cytarabine GDSC1,GDSC2 0.0020 2.0000
NCI-H835 Dabrafenib GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Dactinomycin GDSC2 0.0008 0.8000
NCI-H835 Dactolisib GDSC1,GDSC2 0.0003 0.2500
NCI-H835 Daporinad GDSC1,GDSC2 0.0001 1.0000
NCI-H835 Dasatinib GDSC2 0.0010 2.0000
NCI-H835 Docetaxel GDSC1,GDSC2 0.0000 0.0125
NCI-H835 Doramapimod GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Doxorubicin GDSC1 0.0195 5.0000
NCI-H835 Dyrk1b_0191 GDSC1 0.0391 10.0000
NCI-H835 eEF2K Inhibitor, A-484954 GDSC1 0.0781 20.0000
NCI-H835 EHT-1864 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Elesclomol GDSC1 0.0008 0.2000
NCI-H835 EphB4_9721 GDSC1 0.0391 10.0000
NCI-H835 Epirubicin GDSC2 0.0010 1.0000
NCI-H835 EPZ004777 GDSC2 0.0100 10.0000
NCI-H835 EPZ5676 GDSC2 0.0100 10.0000
NCI-H835 Erlotinib GDSC2 0.0020 2.0000
NCI-H835 ETP-45835 GDSC1 0.0781 20.0000
NCI-H835 FEN1_3940 GDSC1 0.0391 10.0000
NCI-H835 FGFR_0939 GDSC1 0.0098 2.5000
NCI-H835 FGFR_3831 GDSC1 0.0391 10.0000
NCI-H835 Foretinib GDSC2 0.0100 10.0000
NCI-H835 FS106 GDSC1 0.0391 10.0000
NCI-H835 FS112 GDSC1 0.0195 5.0000
NCI-H835 Fulvestrant GDSC1,GDSC2 0.0010 10.0000
NCI-H835 FY012 GDSC1 0.0391 10.0000
NCI-H835 FY026 GDSC1 0.0391 10.0000
NCI-H835 FY069 GDSC1 0.0391 10.0000
NCI-H835 GDC0810 GDSC2 0.0100 10.0000
NCI-H835 Gefitinib GDSC1,GDSC2 0.0020 2.0000
NCI-H835 Gemcitabine GDSC1,GDSC2 0.0001 10.0000
NCI-H835 glutathione GDSC2 0.6403 640.0000
NCI-H835 GNE-317 GDSC2 0.0100 10.0000
NCI-H835 GSK-J4 GDSC1 0.1172 30.0000
NCI-H835 GSK-LSD1-2HCl GDSC2 0.0010 1.0000
NCI-H835 GSK1059615 GDSC1 0.0781 20.0000
NCI-H835 GSK1904529A GDSC2 0.0100 10.0000
NCI-H835 GSK2578215A GDSC2 0.0100 10.0000
NCI-H835 GSK269962A GDSC1 0.0195 5.0000
NCI-H835 GSK2830371 GDSC2 0.0100 10.0000
NCI-H835 GSK343 GDSC2 0.0100 10.0000
NCI-H835 GSK591 GDSC2 0.0100 10.0000
NCI-H835 GW441756 GDSC1,GDSC2 0.0020 2.0000
NCI-H835 HKMTI-1-005 GDSC2 0.0100 10.0000
NCI-H835 I-BET151 GDSC1 0.0391 10.0000
NCI-H835 I-BRD9 GDSC2 0.0100 10.0000
NCI-H835 I-CBP112 GDSC1 0.0391 10.0000
NCI-H835 IAP_5620 GDSC1 0.0391 10.0000
NCI-H835 IAP_7638 GDSC1 0.0391 10.0000
NCI-H835 IC-87114 GDSC1 0.0781 20.0000
NCI-H835 ICL-SIRT078 GDSC2 0.0100 10.0000
NCI-H835 ICL1100013 GDSC1 0.0781 20.0000
NCI-H835 IGFR_3801 GDSC1 0.0391 10.0000
NCI-H835 IMD-0354 GDSC1 0.0781 20.0000
NCI-H835 IOX2 GDSC1 0.0004 0.1000
NCI-H835 Ipatasertib GDSC2 0.0100 10.0000
NCI-H835 Irinotecan GDSC2 0.0100 10.0000
NCI-H835 JAK1_3715 GDSC1 0.0391 10.0000
NCI-H835 JAK3_7406 GDSC1 0.0391 10.0000
NCI-H835 JNJ38877605 GDSC1 0.0781 20.0000
NCI-H835 JNK Inhibitor VIII GDSC1,GDSC2 0.0100 10.0000
NCI-H835 JQ1 GDSC1,GDSC2 0.0039 10.0000
NCI-H835 kb NB 142-70 GDSC1 0.0781 20.0000
NCI-H835 KIN001-042 GDSC1 0.0400 10.2400
NCI-H835 KU-55933 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 KU-60019 GDSC1 0.0391 10.0000
NCI-H835 Lapatinib GDSC2 0.0100 10.0000
NCI-H835 Lenalidomide GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Lestaurtinib GDSC1,GDSC2 0.0020 2.0000
NCI-H835 LGK974 GDSC2 0.0050 10.0000
NCI-H835 LIMK1 inhibitor BMS4 GDSC1 0.0781 20.0000
NCI-H835 Linsitinib GDSC2 0.0100 10.0000
NCI-H835 LJI308 GDSC2 0.0100 10.0000
NCI-H835 Luminespib GDSC2 0.0010 1.0000
NCI-H835 MCT1_6447 GDSC1 0.0391 10.0000
NCI-H835 MCT4_1422 GDSC1 0.0391 10.0000
NCI-H835 Methotrexate GDSC1,GDSC2 0.0008 1.0000
NCI-H835 MG-132 GDSC2 0.0156 4.0000
NCI-H835 MIM1 GDSC2 0.0100 10.0000
NCI-H835 MIRA-1 GDSC2 0.0100 10.0000
NCI-H835 Mirin GDSC1 0.3906 100.0000
NCI-H835 MK-1775 GDSC2 0.0100 10.0000
NCI-H835 MK-2206 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 MK-8776 GDSC2 0.0050 5.0000
NCI-H835 Motesanib GDSC1,GDSC2 0.0078 10.0000
NCI-H835 Mycophenolic acid GDSC2 0.0100 10.0000
NCI-H835 N22899-6-C1 GDSC1 0.0391 10.0000
NCI-H835 N23918-95-7 GDSC1 0.0391 10.0000
NCI-H835 N24798-49-A1 GDSC1 0.0391 10.0000
NCI-H835 N25720-51-A1 GDSC2 0.0100 10.0000
NCI-H835 N27922-53-1 GDSC2 0.0100 10.0000
NCI-H835 N29087-69-1 GDSC2 0.0100 10.0000
NCI-H835 N30652-18-1 GDSC2 0.0100 10.0000
NCI-H835 Navitoclax GDSC1,GDSC2 0.0020 10.0000
NCI-H835 Nilotinib GDSC1,GDSC2 0.0020 2.0000
NCI-H835 NU7441 GDSC1,GDSC2 0.0078 10.0000
NCI-H835 Nutlin-3a GDSC1,GDSC2 0.0080 10.0000
NCI-H835 NVP-ADW742 GDSC2 0.0100 10.0000
NCI-H835 Obatoclax Mesylate GDSC2 0.0100 10.0000
NCI-H835 Olaparib GDSC1,GDSC2 0.0100 10.0000
NCI-H835 OSI-027 GDSC2 0.0040 4.0000
NCI-H835 Osimertinib GDSC2 0.0010 1.0000
NCI-H835 Oxaliplatin GDSC2 0.0100 10.0000
NCI-H835 P22077 GDSC2 0.0100 10.0000
NCI-H835 Paclitaxel GDSC2 0.0000 0.0100
NCI-H835 Palbociclib GDSC1,GDSC2 0.0040 10.0000
NCI-H835 PARP_0108 GDSC1 0.0098 2.5000
NCI-H835 PARP_9482 GDSC1 0.0098 2.5000
NCI-H835 PARP_9495 GDSC1 0.0098 2.5000
NCI-H835 PBD-288 GDSC2 0.0050 5.0000
NCI-H835 PD0325901 GDSC1,GDSC2 0.0003 2.5000
NCI-H835 PD173074 GDSC1,GDSC2 0.0020 10.0000
NCI-H835 Pevonedistat GDSC1,GDSC2 0.0039 10.0000
NCI-H835 PF-00299804 GDSC1 0.0781 20.0000
NCI-H835 PF-4708671 GDSC1 0.0391 10.0000
NCI-H835 PFI-1 GDSC1 0.0391 10.0000
NCI-H835 PFI3 GDSC1 0.0391 10.0000
NCI-H835 PI3Ka_4409 GDSC1 0.0391 10.0000
NCI-H835 Pictilisib GDSC1,GDSC2 0.0040 10.0000
NCI-H835 Pilaralisib GDSC1 0.0781 20.0000
NCI-H835 Piperlongumine GDSC1 0.0391 10.0000
NCI-H835 PLK_6522 GDSC1 0.0024 0.6250
NCI-H835 PLX-4720 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 POMHEX GDSC2 0.0100 10.0000
NCI-H835 Pyridostatin GDSC2 0.0100 10.0000
NCI-H835 RAF_9304 GDSC1 0.0391 10.0000
NCI-H835 Rapamycin GDSC2 0.0000 0.0200
NCI-H835 Refametinib GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Ribociclib GDSC2 0.0020 2.0000
NCI-H835 RO-3306 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 rTRAIL GDSC1 0.0004 0.1000
NCI-H835 Rucaparib GDSC1,GDSC2 0.0050 5.0000
NCI-H835 Sapitinib GDSC2 0.0050 10.0000
NCI-H835 Savolitinib GDSC2 0.0010 1.0000
NCI-H835 SB216763 GDSC1,GDSC2 0.0100 10.0000
NCI-H835 SB505124 GDSC1 0.0391 10.0000
NCI-H835 SB590885 GDSC1,GDSC2 0.0050 5.0000
NCI-H835 SCH772984 GDSC2 0.0050 5.0000
NCI-H835 Selumetinib GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Sepantronium bromide GDSC2 0.0100 10.0000
NCI-H835 Serdemetan GDSC1,GDSC2 0.0100 10.0000
NCI-H835 SGC0946 GDSC1 0.0020 0.5000
NCI-H835 SL0101 GDSC1 0.0391 10.0000
NCI-H835 SN-38 GDSC1,GDSC2 0.0000 0.1000
NCI-H835 Sorafenib GDSC2 0.0100 10.0000
NCI-H835 Sphingosine Kinase 1 Inhibitor II GDSC1 0.0100 2.5600
NCI-H835 Staurosporine GDSC2 0.0078 2.0000
NCI-H835 SU11274 GDSC1 0.0400 10.2400
NCI-H835 Talazoparib GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Tamoxifen GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Tanespimycin GDSC1,GDSC2 0.0010 1.0000
NCI-H835 TANK_1366 GDSC1 0.0098 2.5000
NCI-H835 Taselisib GDSC2 0.0050 10.0000
NCI-H835 Telomerase Inhibitor IX GDSC2 0.0100 10.0000
NCI-H835 Temozolomide GDSC1,GDSC2 0.0300 30.0000
NCI-H835 Temsirolimus GDSC1,GDSC2 0.0008 1.0000
NCI-H835 Tenovin-6 GDSC1 0.0781 20.0000
NCI-H835 THR-101 GDSC2 0.0100 10.0000
NCI-H835 THR-102 GDSC2 0.0100 10.0000
NCI-H835 THR-103 GDSC2 0.0100 10.0000
NCI-H835 Torin 2 GDSC1 0.0781 20.0000
NCI-H835 Trametinib GDSC1,GDSC2 0.0010 1.0000
NCI-H835 Tretinoin GDSC1 0.0391 10.0000
NCI-H835 TTK_3146 GDSC1 0.0391 10.0000
NCI-H835 TW 37 GDSC1,GDSC2 0.0050 5.0000
NCI-H835 TWS119 GDSC1 0.0781 20.0000
NCI-H835 Ulixertinib GDSC2 0.0020 10.0000
NCI-H835 UMI-77 GDSC2 0.0100 10.0000
NCI-H835 UNC0379 GDSC2 0.0100 10.0000
NCI-H835 UNC0638 GDSC1,GDSC2 0.0050 20.0000
NCI-H835 UNC0642 GDSC1 0.0020 0.5000
NCI-H835 UNC1215 GDSC1 0.0039 1.0000
NCI-H835 Uprosertib GDSC2 0.0100 10.0000
NCI-H835 VE821 GDSC2 0.0100 10.0000
NCI-H835 Veliparib GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Venetoclax GDSC2 0.0010 1.0000
NCI-H835 Vinblastine GDSC1,GDSC2 0.0001 0.1000
NCI-H835 Vinorelbine GDSC2 0.0001 0.1000
NCI-H835 Vismodegib GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Vorinostat GDSC1,GDSC2 0.0100 10.0000
NCI-H835 Voxtalisib GDSC1 0.0781 20.0000
NCI-H835 VTP-A GDSC2 0.0010 1.0000
NCI-H835 VTP-B GDSC2 0.0010 1.0000
NCI-H835 VX-11e GDSC2 0.0100 10.0000
NCI-H835 VX-702 GDSC1 0.0078 2.0000
NCI-H835 Wee1 Inhibitor GDSC1,GDSC2 0.0078 10.0000
NCI-H835 WEHI-539 GDSC2 0.0100 10.0000
NCI-H835 WIKI4 GDSC2 0.0100 10.0000
NCI-H835 WYE-125132 GDSC1 0.0400 10.2400
NCI-H835 XAV939 GDSC1 0.0195 5.0000
NCI-H835 YK-4-279 GDSC1,GDSC2 0.0200 20.0000
NCI-H835 ZL049 GDSC1 0.0391 10.0000
NCI-H835 ZL109 GDSC1 0.0391 10.0000
NCI-H835 ZM447439 GDSC1,GDSC2 0.0100 10.0000

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Drugs with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Drugs with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Drugs with highest and lowest AUC