Cell Line : NCI-H748

Cellosaurus Index : CVCL_1588
Cellosaurus ID : NCI-H748

GDSC1 Name , GDSC2 Name : NCI-H748
CCLE Name : NCIH748_LUNG

Cancer Type : lung
Dataset : All

Drug Response Information

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Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including cell line name, drug name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Cellosaurus ID Drug Name Original Dataset(s) Min Dose Max Dose Dose-response
NCI-H748 5-Fluorouracil GDSC1,GDSC2 0.0200 32.0000
NCI-H748 A-443654 GDSC1 0.0040 1.0240
NCI-H748 A-770041 GDSC1 0.0200 5.1200
NCI-H748 ABT737 GDSC2 0.0100 10.0000
NCI-H748 Afatinib GDSC2 0.0040 4.0000
NCI-H748 Afuresertib GDSC2 0.0100 10.0000
NCI-H748 AGI-5198 GDSC2 0.0100 10.0000
NCI-H748 AGI-6780 GDSC2 0.0100 10.0000
NCI-H748 AGK-2 GDSC2 0.0040 4.0000
NCI-H748 AKT inhibitor VIII GDSC1 0.0100 10.2400
NCI-H748 Alectinib GDSC1 0.0200 5.1200
NCI-H748 Alisertib GDSC2 0.0100 10.0000
NCI-H748 Alpelisib GDSC2 0.0100 10.0000
NCI-H748 AMG-319 GDSC2 0.0100 10.0000
NCI-H748 Amuvatinib GDSC1 0.0781 20.0000
NCI-H748 AR-42 GDSC1 0.0200 5.1200
NCI-H748 AS601245 GDSC1 0.0312 8.0000
NCI-H748 AS605240 GDSC1 0.0781 20.0000
NCI-H748 AT-7519 GDSC1 0.0400 10.2400
NCI-H748 AT13148 GDSC2 0.0080 8.0000
NCI-H748 Avagacestat GDSC1,GDSC2 0.0100 10.2400
NCI-H748 Axitinib GDSC2 0.0100 10.0000
NCI-H748 AZ6102 GDSC2 0.0100 10.0000
NCI-H748 AZ628 GDSC1 0.0156 4.0000
NCI-H748 AZ960 GDSC2 0.0100 10.0000
NCI-H748 AZD3759 GDSC2 0.0010 1.0000
NCI-H748 AZD4547 GDSC2 0.0100 10.0000
NCI-H748 AZD5363 GDSC2 0.0100 10.0000
NCI-H748 AZD5582 GDSC2 0.0100 10.0000
NCI-H748 AZD6482 GDSC1,GDSC2 0.0100 10.0000
NCI-H748 AZD6738 GDSC2 0.0100 10.0000
NCI-H748 AZD7762 GDSC2 0.0010 2.0000
NCI-H748 AZD8186 GDSC2 0.0100 10.0000
NCI-H748 BAY-61-3606 GDSC1 0.0312 8.0000
NCI-H748 Belinostat GDSC1 0.0781 20.0000
NCI-H748 Bexarotene GDSC1 0.0312 8.0000
NCI-H748 BI-2536 GDSC1,GDSC2 0.0005 0.5000
NCI-H748 BIBR-1532 GDSC2 0.0100 10.0000
NCI-H748 Bicalutamide GDSC1,GDSC2 0.0040 10.0000
NCI-H748 BIX02189 GDSC1 0.0781 20.0000
NCI-H748 Bleomycin GDSC1 0.2500 64.0000
NCI-H748 BMS-345541 GDSC1,GDSC2 0.0100 16.0000
NCI-H748 BMS-509744 GDSC1 0.0400 10.2400
NCI-H748 BMS-536924 GDSC1,GDSC2 0.0100 10.0000
NCI-H748 BMS-754807 GDSC1,GDSC2 0.0100 10.0000
NCI-H748 Bortezomib GDSC1,GDSC2 0.0000 0.0200
NCI-H748 Bosutinib GDSC2 0.0020 2.0000
NCI-H748 Bryostatin 1 GDSC1 0.0000 0.0080
NCI-H748 Buparlisib GDSC2 0.0100 10.0000
NCI-H748 BX-912 GDSC1 0.0400 10.2400
NCI-H748 BX795 GDSC2 0.0100 10.0000
NCI-H748 Cabozantinib GDSC1 0.0200 5.1200
NCI-H748 Camptothecin GDSC2 0.0001 0.1000
NCI-H748 CAY10603 GDSC1 0.0781 20.0000
NCI-H748 CCT-018159 GDSC2 0.0100 10.0000
NCI-H748 CCT007093 GDSC2 0.0100 10.0000
NCI-H748 Cediranib GDSC2 0.0100 10.0000
NCI-H748 CGP-082996 GDSC1 0.0200 5.1200
NCI-H748 CGP-60474 GDSC1 0.0010 0.2560
NCI-H748 CHIR-99021 GDSC1,GDSC2 0.0100 10.0000
NCI-H748 CMK GDSC1 0.0156 4.0000
NCI-H748 CP466722 GDSC1 0.0625 16.0000
NCI-H748 CP724714 GDSC1 0.0400 10.2400
NCI-H748 Crizotinib GDSC1,GDSC2 0.0040 8.0000
NCI-H748 CUDC-101 GDSC1 0.0200 5.1200
NCI-H748 CX-5461 GDSC1 0.0400 10.2400
NCI-H748 Cyclopamine GDSC1 0.0625 16.0000
NCI-H748 Cyclophosphamide GDSC2 0.0100 10.0000
NCI-H748 CZC24832 GDSC2 0.0100 10.0000
NCI-H748 Dabrafenib GDSC2 0.0100 10.0000
NCI-H748 Dacinostat GDSC1 0.0040 1.0240
NCI-H748 Dactinomycin GDSC2 0.0008 0.8000
NCI-H748 Dactolisib GDSC2 0.0003 0.2500
NCI-H748 Daporinad GDSC2 0.0010 1.0000
NCI-H748 Dasatinib GDSC1,GDSC2 0.0020 2.0000
NCI-H748 Dinaciclib GDSC2 0.0010 1.0000
NCI-H748 DMOG GDSC1 15.6250 4000.0000
NCI-H748 Docetaxel GDSC2 0.0000 0.0125
NCI-H748 Doramapimod GDSC2 0.0100 10.0000
NCI-H748 Doxorubicin GDSC1 0.0040 1.0240
NCI-H748 EHT-1864 GDSC2 0.0100 10.0000
NCI-H748 Elesclomol GDSC2 0.0002 0.2000
NCI-H748 Embelin GDSC1 0.1250 32.0000
NCI-H748 Entinostat GDSC1,GDSC2 0.0100 10.0000
NCI-H748 Entospletinib GDSC2 0.0100 10.0000
NCI-H748 Enzastaurin GDSC1 0.0781 20.0000
NCI-H748 Epirubicin GDSC2 0.0100 10.0000
NCI-H748 Epothilone B GDSC1 0.0001 0.0320
NCI-H748 EPZ004777 GDSC2 0.0100 10.0000
NCI-H748 EPZ5676 GDSC2 0.0100 10.0000
NCI-H748 Erlotinib GDSC1,GDSC2 0.0078 10.0000
NCI-H748 Etoposide GDSC1 0.0625 16.0000
NCI-H748 Fedratinib GDSC1 0.0400 10.2400
NCI-H748 FH535 GDSC1 0.1250 32.0000
NCI-H748 Foretinib GDSC1,GDSC2 0.0100 10.0000
NCI-H748 FR-180204 GDSC1 0.0781 20.0000
NCI-H748 FTI-277 GDSC1 0.0040 1.0240
NCI-H748 Fulvestrant GDSC2 0.0010 1.0000
NCI-H748 GDC0810 GDSC2 0.0100 10.0000
NCI-H748 Gefitinib GDSC2 0.0020 2.0000
NCI-H748 Gemcitabine GDSC1,GDSC2 0.0040 10.0000
NCI-H748 Genentech Cpd 10 GDSC1 0.0400 10.2400
NCI-H748 GNE-317 GDSC2 0.0100 10.0000
NCI-H748 GNF-2 GDSC1 0.0050 1.2800
NCI-H748 GSK1070916 GDSC1 0.0100 2.5600
NCI-H748 GSK1904529A GDSC1,GDSC2 0.0040 5.0000
NCI-H748 GSK2578215A GDSC2 0.0100 10.0000
NCI-H748 GSK2606414 GDSC2 0.0100 10.0000
NCI-H748 GSK269962A GDSC1,GDSC2 0.0098 10.0000
NCI-H748 GSK319347A GDSC1 0.0195 5.0000
NCI-H748 GSK343 GDSC2 0.0010 1.0000
NCI-H748 GSK429286A GDSC1 0.0781 20.0000
NCI-H748 GSK591 GDSC2 0.0100 10.0000
NCI-H748 GSK650394 GDSC1 0.0625 16.0000
NCI-H748 GSK690693 GDSC1 0.0400 10.2400
NCI-H748 GW-2580 GDSC1 0.0781 20.0000
NCI-H748 GW441756 GDSC2 0.0020 2.0000
NCI-H748 GW843682X GDSC1 0.0010 0.2560
NCI-H748 HG6-64-1 GDSC1 0.0200 5.1200
NCI-H748 I-BET-762 GDSC1,GDSC2 0.0100 20.0000
NCI-H748 I-BRD9 GDSC2 0.0100 10.0000
NCI-H748 Ibrutinib GDSC2 0.0100 10.0000
NCI-H748 Idelalisib GDSC1 0.0781 20.0000
NCI-H748 Imatinib GDSC1 0.0078 2.0000
NCI-H748 IOX2 GDSC2 0.0005 0.5000
NCI-H748 IPA-3 GDSC1 0.1250 32.0000
NCI-H748 Ipatasertib GDSC2 0.0100 10.0000
NCI-H748 Irinotecan GDSC2 0.0050 5.0000
NCI-H748 Ispinesib Mesylate GDSC1 0.0005 0.1280
NCI-H748 IWP-2 GDSC2 0.0010 1.0000
NCI-H748 JNK Inhibitor VIII GDSC2 0.0100 10.0000
NCI-H748 JNK-9L GDSC1 0.0200 5.1200
NCI-H748 JQ1 GDSC1,GDSC2 0.0100 10.0000
NCI-H748 JQ12 GDSC1 0.0200 5.1200
NCI-H748 JW-7-24-1 GDSC1 0.0400 10.2400
NCI-H748 JW-7-52-1 GDSC1 0.0047 1.2000
NCI-H748 KIN001-236 GDSC1 0.0400 10.2400
NCI-H748 KIN001-244 GDSC1 0.0781 20.0000
NCI-H748 KIN001-260 GDSC1 0.0781 20.0000
NCI-H748 KIN001-266 GDSC1 0.0781 20.0000
NCI-H748 KIN001-270 GDSC1 0.0781 20.0000
NCI-H748 KRAS (G12C) Inhibitor-12 GDSC2 0.0200 20.0000
NCI-H748 KU-55933 GDSC2 0.0100 10.0000
NCI-H748 Lapatinib GDSC1,GDSC2 0.0078 10.0000
NCI-H748 LCL161 GDSC2 0.0100 10.0000
NCI-H748 Leflunomide GDSC2 0.1001 100.0000
NCI-H748 Lenalidomide GDSC2 0.0100 10.0000
NCI-H748 Lestaurtinib GDSC2 0.0020 2.0000
NCI-H748 LFM-A13 GDSC1 0.0625 16.0000
NCI-H748 LGK974 GDSC2 0.0100 10.0000
NCI-H748 Linifanib GDSC1 0.0040 1.0240
NCI-H748 Linsitinib GDSC1,GDSC2 0.0100 10.0000
NCI-H748 LJI308 GDSC2 0.0100 10.0000
NCI-H748 Luminespib GDSC1,GDSC2 0.0003 0.2560
NCI-H748 LY2109761 GDSC2 0.0050 5.0000
NCI-H748 Masitinib GDSC1 0.0781 20.0000
NCI-H748 Methotrexate GDSC2 0.0010 1.0000
NCI-H748 MG-132 GDSC1,GDSC2 0.0039 4.0000
NCI-H748 Midostaurin GDSC1 0.0020 0.5120
NCI-H748 MIRA-1 GDSC2 0.0100 10.0000
NCI-H748 Mirin GDSC2 0.1001 100.0000
NCI-H748 Mitomycin-C GDSC1 0.0625 16.0000
NCI-H748 MK-1775 GDSC2 0.0100 10.0000
NCI-H748 MK-2206 GDSC2 0.0100 10.0000
NCI-H748 MK-8776 GDSC2 0.0050 5.0000
NCI-H748 ML323 GDSC2 0.0200 20.0000
NCI-H748 MN-64 GDSC2 0.0100 10.0000
NCI-H748 Motesanib GDSC2 0.0100 10.0000
NCI-H748 MPS-1-IN-1 GDSC1 0.0781 20.0000
NCI-H748 Navitoclax GDSC2 0.0020 2.0000
NCI-H748 NG-25 GDSC1 0.0400 10.2400
NCI-H748 Nilotinib GDSC2 0.0100 10.0000
NCI-H748 Niraparib GDSC2 0.0100 10.0000
NCI-H748 NPK76-II-72-1 GDSC1 0.0400 10.2400
NCI-H748 NSC-207895 GDSC1 0.0781 20.0000
NCI-H748 NSC-87877 GDSC1 0.0625 16.0000
NCI-H748 NU7441 GDSC2 0.0100 10.0000
NCI-H748 Nutlin-3a GDSC2 0.0100 10.0000
NCI-H748 NVP-ADW742 GDSC2 0.0100 10.0000
NCI-H748 NVP-BHG712 GDSC1 0.0400 10.2400
NCI-H748 NVP-TAE684 GDSC1 0.0078 2.0000
NCI-H748 Obatoclax Mesylate GDSC1 0.0625 16.0000
NCI-H748 OF-1 GDSC2 0.0100 10.0000
NCI-H748 Olaparib GDSC2 0.0100 10.0000
NCI-H748 Omipalisib GDSC1 0.0005 0.1280
NCI-H748 OSI-027 GDSC1,GDSC2 0.0100 20.0000
NCI-H748 OSI-930 GDSC1 0.0400 10.2400
NCI-H748 Osimertinib GDSC2 0.0010 1.0000
NCI-H748 OSU-03012 GDSC1 0.0625 16.0000
NCI-H748 OTX015 GDSC2 0.0100 10.0000
NCI-H748 Oxaliplatin GDSC2 0.0100 10.0000
NCI-H748 P22077 GDSC2 0.0100 10.0000
NCI-H748 PAC-1 GDSC1 0.0100 2.5600
NCI-H748 Paclitaxel GDSC1,GDSC2 0.0001 0.1024
NCI-H748 Palbociclib GDSC2 0.0040 4.0000
NCI-H748 Parthenolide GDSC1 0.0195 5.0000
NCI-H748 Pazopanib GDSC1 0.0312 8.0000
NCI-H748 PCI-34051 GDSC2 0.0100 10.0000
NCI-H748 PD0325901 GDSC2 0.0025 2.5000
NCI-H748 PD173074 GDSC2 0.0100 10.0000
NCI-H748 Pelitinib GDSC1 0.0098 2.5000
NCI-H748 Pevonedistat GDSC2 0.0100 10.0000
NCI-H748 PF-4708671 GDSC2 0.0100 10.0000
NCI-H748 PF-562271 GDSC1 0.0100 2.5600
NCI-H748 PFI-1 GDSC2 0.0100 10.0000
NCI-H748 PFI3 GDSC2 0.0100 10.0000
NCI-H748 PHA-665752 GDSC1 0.0078 2.0000
NCI-H748 PHA-793887 GDSC1 0.0400 10.2400
NCI-H748 Phenformin GDSC1 15.6250 4000.0000
NCI-H748 PI-103 GDSC1 0.0400 10.2400
NCI-H748 Picolinici-acid GDSC2 0.0100 10.0000
NCI-H748 Pictilisib GDSC2 0.0040 4.0000
NCI-H748 PIK-93 GDSC1 0.0781 20.0000
NCI-H748 Piperlongumine GDSC2 0.0100 10.0000
NCI-H748 PLX-4720 GDSC2 0.0100 10.0000
NCI-H748 Ponatinib GDSC1 0.0020 0.5120
NCI-H748 PRIMA-1MET GDSC2 0.0300 30.0000
NCI-H748 PRT062607 GDSC2 0.0100 10.0000
NCI-H748 Pyridostatin GDSC2 0.0100 10.0000
NCI-H748 Pyrimethamine GDSC1 0.0781 20.0000
NCI-H748 QL-X-138 GDSC1 0.0400 10.2400
NCI-H748 QL-XI-92 GDSC1 0.0400 10.2400
NCI-H748 QL-XII-47 GDSC1 0.0400 10.2400
NCI-H748 QS11 GDSC1 0.0400 10.2400
NCI-H748 Quizartinib GDSC1 0.0040 1.0240
NCI-H748 Rapamycin GDSC1,GDSC2 0.0001 0.1000
NCI-H748 Refametinib GDSC2 0.0100 10.0000
NCI-H748 Ribociclib GDSC2 0.0020 2.0000
NCI-H748 RO-3306 GDSC2 0.0100 10.0000
NCI-H748 Rucaparib GDSC2 0.0050 5.0000
NCI-H748 Ruxolitinib GDSC1,GDSC2 0.0100 10.0000
NCI-H748 RVX-208 GDSC2 0.0100 10.0000
NCI-H748 S-Trityl-L-cysteine GDSC1 0.0200 5.1200
NCI-H748 Sabutoclax GDSC2 0.0100 10.0000
NCI-H748 Salubrinal GDSC1 0.0625 16.0000
NCI-H748 Sapitinib GDSC2 0.0050 5.0000
NCI-H748 Saracatinib GDSC1 0.0078 2.0000
NCI-H748 Savolitinib GDSC2 0.0010 1.0000
NCI-H748 SB216763 GDSC2 0.0100 10.0000
NCI-H748 SB505124 GDSC2 0.0100 10.0000
NCI-H748 SB52334 GDSC1 0.0781 20.0000
NCI-H748 SB590885 GDSC2 0.0050 5.0000
NCI-H748 SCH772984 GDSC2 0.0050 5.0000
NCI-H748 Seliciclib GDSC1 0.0625 16.0000
NCI-H748 Selisistat GDSC1 0.0781 20.0000
NCI-H748 Selumetinib GDSC2 0.0100 10.0000
NCI-H748 Sepantronium bromide GDSC1,GDSC2 0.0100 10.0000
NCI-H748 Serdemetan GDSC2 0.0100 10.0000
NCI-H748 SGC0946 GDSC2 0.0005 0.5000
NCI-H748 Shikonin GDSC1 0.0625 16.0000
NCI-H748 SL0101 GDSC2 0.0100 10.0000
NCI-H748 SN-38 GDSC2 0.0100 10.0000
NCI-H748 SNX-2112 GDSC1 0.0100 2.5600
NCI-H748 Sorafenib GDSC1,GDSC2 0.0100 10.0000
NCI-H748 Staurosporine GDSC2 0.0078 2.0000
NCI-H748 STF-62247 GDSC1 0.0400 10.2400
NCI-H748 Sunitinib GDSC1 0.0312 8.0000
NCI-H748 T0901317 GDSC1 0.0400 10.2400
NCI-H748 TAK-715 GDSC1 0.0781 20.0000
NCI-H748 Talazoparib GDSC2 0.0100 10.0000
NCI-H748 Tamoxifen GDSC2 0.0100 10.0000
NCI-H748 Tanespimycin GDSC2 0.0010 1.0000
NCI-H748 Taselisib GDSC2 0.0100 10.0000
NCI-H748 Telomerase Inhibitor IX GDSC2 0.0100 10.0000
NCI-H748 Temozolomide GDSC2 0.0300 30.0000
NCI-H748 Temsirolimus GDSC2 0.0010 1.0000
NCI-H748 TGX221 GDSC1 0.0391 10.0000
NCI-H748 Thapsigargin GDSC1 0.0020 0.5120
NCI-H748 THZ-2-102-1 GDSC1 0.0098 2.5000
NCI-H748 THZ-2-49 GDSC1 0.0781 20.0000
NCI-H748 Tipifarnib GDSC1 0.0625 16.0000
NCI-H748 Tivozanib GDSC1 0.0005 0.1280
NCI-H748 TL-1-85 GDSC1 0.0400 10.2400
NCI-H748 TL-2-105 GDSC1 0.0400 10.2400
NCI-H748 Tozasertib GDSC1,GDSC2 0.0050 5.0000
NCI-H748 TPCA-1 GDSC1 0.0781 20.0000
NCI-H748 Trametinib GDSC2 0.0010 1.0000
NCI-H748 Tretinoin GDSC2 0.0100 10.0000
NCI-H748 Tubastatin A GDSC1 0.0781 20.0000
NCI-H748 Ulixertinib GDSC2 0.0100 10.0000
NCI-H748 UNC0638 GDSC1 0.1562 40.0000
NCI-H748 Uprosertib GDSC2 0.0100 10.0000
NCI-H748 VE-822 GDSC2 0.0050 5.0000
NCI-H748 VE821 GDSC2 0.0100 10.0000
NCI-H748 Veliparib GDSC2 0.0100 10.0000
NCI-H748 Venetoclax GDSC2 0.0010 1.0000
NCI-H748 Vinorelbine GDSC1,GDSC2 0.0001 0.1000
NCI-H748 Vismodegib GDSC2 0.0100 10.0000
NCI-H748 VNLG-124 GDSC1 0.0200 5.1200
NCI-H748 Vorinostat GDSC2 0.0100 10.0000
NCI-H748 VX-11e GDSC1,GDSC2 0.0100 10.0000
NCI-H748 Wee1 Inhibitor GDSC2 0.0100 10.0000
NCI-H748 WEHI-539 GDSC2 0.0100 10.0000
NCI-H748 WH-4-023 GDSC1 0.0200 5.1200
NCI-H748 WHI-P97 GDSC1 0.0400 10.2400
NCI-H748 WIKI4 GDSC2 0.0100 10.0000
NCI-H748 Wnt-C59 GDSC2 0.0100 10.0000
NCI-H748 WZ-1-84 GDSC1 0.0400 10.2400
NCI-H748 WZ3105 GDSC1 0.0050 1.2800
NCI-H748 WZ4003 GDSC2 0.0100 10.0000
NCI-H748 XAV939 GDSC2 0.0050 5.0000
NCI-H748 XMD13-2 GDSC1 0.0400 10.2400
NCI-H748 XMD14-99 GDSC1 0.0400 10.2400
NCI-H748 XMD15-27 GDSC1 0.0400 10.2400
NCI-H748 XMD8-85 GDSC1 0.0312 8.0000
NCI-H748 Y-39983 GDSC1 0.0781 20.0000
NCI-H748 YK-4-279 GDSC2 0.0100 10.0000
NCI-H748 YM201636 GDSC1 0.0200 5.1200
NCI-H748 Z-LLNle-CHO GDSC1 0.0100 2.5600
NCI-H748 Zibotentan GDSC1 0.0781 20.0000
NCI-H748 ZM447439 GDSC2 0.0100 10.0000
NCI-H748 ZSTK474 GDSC1 0.0200 5.1200

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Drugs with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Drugs with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Drugs with highest and lowest AUC