Drug : Orteronel

CTRP1 Name : orteronel

Dataset : All
Synonyms :
Targets : CYP17A1
Pathways : inhibitor of 17,20 lyase (Cytochrome P450 17A1)

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
orteronel MCF-7 CTRP1 1.0417 133.3300
orteronel GAMG CTRP1 0.2603 33.3330
orteronel LN-229 CTRP1 1.0417 133.3300
orteronel SF295 CTRP1 0.2603 33.3330
orteronel HEC-108 CTRP1 0.2603 33.3330
orteronel HEC-151 CTRP1 0.5208 133.3300
orteronel HEC-251 CTRP1 0.2603 33.3330
orteronel HEC-265 CTRP1 0.2603 33.3330
orteronel HEC-59 CTRP1 0.2603 33.3330
orteronel HEC-6 CTRP1 0.2603 33.3330
orteronel ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
orteronel JHUEM-2 CTRP1 1.0417 133.3300
orteronel KLE CTRP1 0.2603 33.3330
orteronel MFE-319 CTRP1 0.2603 33.3330
orteronel SNG-M CTRP1 0.2603 33.3330
orteronel AMO1 CTRP1 0.5208 133.3300
orteronel BL-70 CTRP1 0.2603 33.3330
orteronel EJM CTRP1 1.0417 133.3300
orteronel GDM-1 CTRP1 1.0417 133.3300
orteronel HT CTRP1 0.2603 33.3330
orteronel KMS-11 CTRP1 0.5208 133.3300
orteronel KU812 CTRP1 0.2603 33.3330
orteronel LP-1 CTRP1 0.5208 133.3300
orteronel MC116 CTRP1 0.2603 33.3330
orteronel MOLM-16 CTRP1 1.0417 133.3300
orteronel NOMO-1 CTRP1 1.0417 133.3300
orteronel NU-DUL-1 CTRP1 1.0417 133.3300
orteronel OCI-AML-3 CTRP1 1.0417 133.3300
orteronel OCI-LY10 CTRP1 0.5208 133.3300
orteronel P3HR-1 CTRP1 0.2603 33.3330
orteronel PL21 CTRP1 1.0417 133.3300
orteronel RPMI-8226 CTRP1 1.0417 133.3300
orteronel SKM-1 CTRP1 1.0417 133.3300
orteronel SU-DHL-4 CTRP1 1.0417 133.3300
orteronel SU-DHL-5 CTRP1 1.0417 133.3300
orteronel THP-1 CTRP1 1.0417 133.3300
orteronel U-937 CTRP1 1.0417 133.3300
orteronel WSU-DLCL2 CTRP1 1.0417 133.3300
orteronel VMRC-RCW CTRP1 0.2603 33.3330
orteronel CL-34 CTRP1 1.0417 133.3300
orteronel CL-40 CTRP1 1.0417 133.3300
orteronel COLO320 CTRP1 1.0417 133.3300
orteronel COLO678 CTRP1 1.0417 133.3300
orteronel CW-2 CTRP1 1.0417 133.3300
orteronel HCT116 CTRP1 1.0417 133.3300
orteronel HCT8 CTRP1 1.0417 133.3300
orteronel HT115 CTRP1 1.0417 133.3300
orteronel HT-29 CTRP1 1.0417 133.3300
orteronel HT-55 CTRP1 1.0417 133.3300
orteronel KM12 CTRP1 1.0417 133.3300
orteronel LOVO CTRP1 1.0417 133.3300
orteronel LS123 CTRP1 1.0417 133.3300
orteronel LS180 CTRP1 0.5208 133.3300
orteronel MDST8 CTRP1 1.0417 133.3300
orteronel NCI-H508 CTRP1 1.0417 133.3300
orteronel RCM-1[HUMANESC] CTRP1 1.0417 133.3300
orteronel RKO CTRP1 1.0417 133.3300
orteronel SNU-1040 CTRP1 1.0417 133.3300
orteronel SNU-175 CTRP1 1.0417 133.3300
orteronel SNU-61 CTRP1 1.0417 133.3300
orteronel SNU-81 CTRP1 1.0417 133.3300
orteronel SNU-C2A CTRP1 0.2603 33.3330
orteronel SNU-C4 CTRP1 1.0417 133.3300
orteronel SNU-C5 CTRP1 1.0417 133.3300
orteronel SW403 CTRP1 0.2603 33.3330
orteronel SW480 CTRP1 1.0417 133.3300
orteronel SW620 CTRP1 1.0417 133.3300
orteronel SW948 CTRP1 1.0417 133.3300
orteronel HEP-G2 CTRP1 1.0417 133.3300
orteronel JHH-6 CTRP1 0.2603 33.3330
orteronel SNU-398 CTRP1 0.5208 133.3300
orteronel SNU-449 CTRP1 0.2603 33.3330
orteronel A-549 CTRP1 0.2603 33.3330
orteronel CAL-12T CTRP1 1.0417 133.3300
orteronel CALU-3 CTRP1 0.2603 33.3330
orteronel CALU-6 CTRP1 0.2603 33.3330
orteronel CHAGO-K-1 CTRP1 0.2603 33.3330
orteronel COLO668 CTRP1 0.2603 33.3330
orteronel COLO699 CTRP1 1.0417 133.3300
orteronel COR-L23 CTRP1 1.0417 133.3300
orteronel COR-L279 CTRP1 0.2603 33.3330
orteronel COR-L51 CTRP1 0.5208 133.3300
orteronel COR-L88 CTRP1 0.2603 33.3330
orteronel DMS273 CTRP1 0.2603 33.3330
orteronel EPLC-272H CTRP1 0.2603 33.3330
orteronel HCC1195 CTRP1 1.0417 133.3300
orteronel HCC1359 CTRP1 1.0417 133.3300
orteronel HCC15 CTRP1 1.0417 133.3300
orteronel HCC1833 CTRP1 1.0417 133.3300
orteronel HCC2108 CTRP1 1.0417 133.3300
orteronel HCC2935 CTRP1 1.0417 133.3300
orteronel HCC4006 CTRP1 1.0417 133.3300
orteronel HCC827 CTRP1 1.0417 133.3300
orteronel KNS-62 CTRP1 0.2603 33.3330
orteronel LCLC-97TM1 CTRP1 0.2603 33.3330
orteronel LXF289 CTRP1 0.2603 33.3330
orteronel NCI-H1048 CTRP1 0.2603 33.3330
orteronel NCI-H1105 CTRP1 1.0417 133.3300
orteronel NCI-H1299 CTRP1 0.2603 33.3330
orteronel NCI-H1355 CTRP1 0.2603 33.3330
orteronel NCI-H1435 CTRP1 0.2603 33.3330
orteronel NCI-H1437 CTRP1 0.2603 33.3330
orteronel NCI-H1568 CTRP1 0.2603 33.3330
orteronel NCI-H1573 CTRP1 0.2603 33.3330
orteronel NCI-H1666 CTRP1 0.2603 33.3330
orteronel NCI-H1694 CTRP1 1.0417 133.3300
orteronel NCI-H1755 CTRP1 1.0417 133.3300
orteronel NCI-H1781 CTRP1 1.0417 133.3300
orteronel NCI-H1792 CTRP1 0.2603 33.3330
orteronel NCI-H1836 CTRP1 1.0417 133.3300
orteronel NCI-H1876 CTRP1 1.0417 133.3300
orteronel NCI-H1915 CTRP1 0.2603 33.3330
orteronel NCI-H1930 CTRP1 0.2603 33.3330
orteronel NCI-H1944 CTRP1 0.2603 33.3330
orteronel NCI-H1963 CTRP1 0.5208 133.3300
orteronel NCI-H1975 CTRP1 0.2603 33.3330
orteronel NCI-H2009 CTRP1 0.2603 33.3330
orteronel NCI-H2023 CTRP1 1.0417 133.3300
orteronel NCI-H2029 CTRP1 0.2603 33.3330
orteronel NCI-H2030 CTRP1 1.0417 133.3300
orteronel NCI-H2073 CTRP1 1.0417 133.3300
orteronel NCI-H2081 CTRP1 1.0417 133.3300
orteronel NCI-H2110 CTRP1 1.0417 133.3300
orteronel NCI-H2122 CTRP1 1.0417 133.3300
orteronel NCI-H2141 CTRP1 0.5208 133.3300
orteronel NCI-H2172 CTRP1 1.0417 133.3300
orteronel NCI-H2286 CTRP1 0.2603 33.3330
orteronel NCI-H23 CTRP1 0.2603 33.3330
orteronel NCI-H2342 CTRP1 1.0417 133.3300
orteronel NCI-H2405 CTRP1 0.2603 33.3330
orteronel NCI-H3255 CTRP1 1.0417 133.3300
orteronel NCI-H441 CTRP1 1.0417 133.3300
orteronel NCI-H460 CTRP1 1.0417 133.3300
orteronel NCI-H596 CTRP1 1.0417 133.3300
orteronel NCI-H650 CTRP1 0.2603 33.3330
orteronel NCI-H810 CTRP1 0.2603 33.3330
orteronel NCI-H82 CTRP1 0.2603 33.3330
orteronel NCI-H841 CTRP1 1.0417 133.3300
orteronel RERF-LC-KJ CTRP1 0.2603 33.3330
orteronel SCLC-21H CTRP1 0.5208 133.3300
orteronel SK-LU-1 CTRP1 1.0417 133.3300
orteronel SQ-1 CTRP1 1.0417 133.3300
orteronel T3M-10 CTRP1 1.0417 133.3300
orteronel VMRC-LCD CTRP1 0.2603 33.3330
orteronel KYSE-140 CTRP1 0.2603 33.3330
orteronel KYSE-410 CTRP1 0.2603 33.3330
orteronel KYSE-450 CTRP1 0.2603 33.3330
orteronel A2780 CTRP1 0.5208 133.3300
orteronel CAOV-3 CTRP1 1.0417 133.3300
orteronel COV318 CTRP1 0.2603 33.3330
orteronel COV362 CTRP1 1.0417 133.3300
orteronel COV434 CTRP1 1.0417 133.3300
orteronel COV644 CTRP1 1.0417 133.3300
orteronel EFO-21 CTRP1 0.2603 33.3330
orteronel EFO-27 CTRP1 1.0417 133.3300
orteronel HEYA8 CTRP1 0.2603 33.3330
orteronel IGROV-1 CTRP1 0.5208 133.3300
orteronel JHOC-5 CTRP1 1.0417 133.3300
orteronel JHOM-1 CTRP1 1.0417 133.3300
orteronel JHOS-4 CTRP1 0.2603 33.3330
orteronel OAW42 CTRP1 1.0417 133.3300
orteronel OV7 CTRP1 1.0417 133.3300
orteronel OV-90 CTRP1 1.0417 133.3300
orteronel OVCAR-4 CTRP1 0.5208 133.3300
orteronel OVCAR-8 CTRP1 0.5208 133.3300
orteronel OVK18 CTRP1 1.0417 133.3300
orteronel OVKATE CTRP1 0.5208 133.3300
orteronel OVMANA CTRP1 0.2603 33.3330
orteronel RKN CTRP1 0.5208 133.3300
orteronel RMG-I CTRP1 1.0417 133.3300
orteronel RMUG-S CTRP1 1.0417 133.3300
orteronel SK-OV-3 CTRP1 0.2603 33.3330
orteronel SNU-840 CTRP1 1.0417 133.3300
orteronel TYK-NU CTRP1 1.0417 133.3300
orteronel CAPAN-2 CTRP1 0.2603 33.3330
orteronel HUP-T4 CTRP1 0.2603 33.3330
orteronel KP-3 CTRP1 0.2603 33.3330
orteronel PANC03.27 CTRP1 0.2603 33.3330
orteronel PATU8902 CTRP1 0.2603 33.3330
orteronel QGP-1 CTRP1 0.2603 33.3330
orteronel SUIT-2 CTRP1 0.2603 33.3330
orteronel MSTO-211H CTRP1 0.2603 33.3330
orteronel NCI-H2052 CTRP1 0.2603 33.3330
orteronel NCI-H28 CTRP1 0.2603 33.3330
orteronel MIAPACA-3 CTRP1 0.2603 33.3330
orteronel A-375 CTRP1 1.0417 133.3300
orteronel G-361 CTRP1 0.2603 33.3330
orteronel HS852.T CTRP1 0.2603 33.3330
orteronel HS936.T CTRP1 0.2603 33.3330
orteronel HS944.T CTRP1 0.2603 33.3330
orteronel SK-MEL-1 CTRP1 1.0417 133.3300
orteronel SK-MEL-28 CTRP1 1.0417 133.3300
orteronel SK-MEL-5 CTRP1 1.0417 133.3300
orteronel G-401 CTRP1 0.2603 33.3330
orteronel HT-1080 CTRP1 1.0417 133.3300
orteronel AGS CTRP1 0.5208 133.3300
orteronel FU97 CTRP1 0.2603 33.3330
orteronel KE-97 CTRP1 0.2603 33.3330
orteronel MKN7 CTRP1 0.2603 33.3330
orteronel MKN74 CTRP1 0.2603 33.3330
orteronel NUGC-4 CTRP1 0.2603 33.3330
orteronel SH-10-TC CTRP1 0.2603 33.3330
orteronel HSC-2 CTRP1 0.2603 33.3330
orteronel SCC-9 CTRP1 0.5208 133.3300
orteronel 5637 CTRP1 0.2603 33.3330
orteronel HT-1376 CTRP1 0.2603 33.3330
orteronel KMBC-2 CTRP1 0.2603 33.3330
orteronel RT-4 CTRP1 0.2603 33.3330
orteronel UM-UC-3 CTRP1 0.2603 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.