Drug : Fumagillol

CTRP1 Name : fumagillol

Dataset : All
Synonyms :
Targets : METAP2
Pathways : natural product;inhibitor of methionyl aminopeptidase 2

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
fumagillol MCF-7 CTRP1 4.1667 533.3300
fumagillol GAMG CTRP1 0.2603 33.3330
fumagillol LN-229 CTRP1 4.1667 533.3300
fumagillol SF295 CTRP1 0.2603 33.3330
fumagillol HEC-108 CTRP1 0.2603 33.3330
fumagillol HEC-151 CTRP1 4.1667 533.3300
fumagillol HEC-251 CTRP1 0.2603 33.3330
fumagillol HEC-265 CTRP1 0.2603 33.3330
fumagillol HEC-59 CTRP1 0.2603 33.3330
fumagillol HEC-6 CTRP1 0.2603 33.3330
fumagillol ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
fumagillol JHUEM-2 CTRP1 4.1667 533.3300
fumagillol KLE CTRP1 0.2603 33.3330
fumagillol MFE-319 CTRP1 0.2603 33.3330
fumagillol SNG-M CTRP1 0.2603 33.3330
fumagillol AMO1 CTRP1 4.1667 533.3300
fumagillol BL-70 CTRP1 0.2603 33.3330
fumagillol EJM CTRP1 4.1667 533.3300
fumagillol GDM-1 CTRP1 4.1667 533.3300
fumagillol HT CTRP1 0.2603 33.3330
fumagillol KMS-11 CTRP1 4.1667 533.3300
fumagillol KU812 CTRP1 0.2603 33.3330
fumagillol LP-1 CTRP1 4.1667 533.3300
fumagillol MC116 CTRP1 0.2603 33.3330
fumagillol MOLM-16 CTRP1 4.1667 533.3300
fumagillol NOMO-1 CTRP1 4.1667 533.3300
fumagillol NU-DUL-1 CTRP1 4.1667 533.3300
fumagillol OCI-AML-3 CTRP1 4.1667 533.3300
fumagillol OCI-LY10 CTRP1 4.1667 533.3300
fumagillol P3HR-1 CTRP1 0.2603 33.3330
fumagillol PL21 CTRP1 4.1667 533.3300
fumagillol RPMI-8226 CTRP1 4.1667 533.3300
fumagillol SKM-1 CTRP1 4.1667 533.3300
fumagillol SU-DHL-4 CTRP1 4.1667 533.3300
fumagillol SU-DHL-5 CTRP1 4.1667 533.3300
fumagillol THP-1 CTRP1 4.1667 533.3300
fumagillol U-937 CTRP1 4.1667 533.3300
fumagillol WSU-DLCL2 CTRP1 4.1667 533.3300
fumagillol RCC10RGB CTRP1 4.1667 533.3300
fumagillol VMRC-RCW CTRP1 0.2603 33.3330
fumagillol C2BBE1 CTRP1 0.2603 33.3330
fumagillol CL-34 CTRP1 4.1667 533.3300
fumagillol CL-40 CTRP1 4.1667 533.3300
fumagillol COLO205 CTRP1 0.2603 33.3330
fumagillol COLO320 CTRP1 4.1667 533.3300
fumagillol COLO678 CTRP1 4.1667 533.3300
fumagillol CW-2 CTRP1 4.1667 533.3300
fumagillol DLD-1 CTRP1 0.2603 33.3330
fumagillol GP2D CTRP1 0.2603 33.3330
fumagillol HCT116 CTRP1 4.1667 533.3300
fumagillol HCT8 CTRP1 4.1667 533.3300
fumagillol HT115 CTRP1 4.1667 533.3300
fumagillol HT-29 CTRP1 4.1667 533.3300
fumagillol HT-55 CTRP1 4.1667 533.3300
fumagillol KM12 CTRP1 4.1667 533.3300
fumagillol LOVO CTRP1 4.1667 533.3300
fumagillol LS123 CTRP1 4.1667 533.3300
fumagillol LS180 CTRP1 4.1667 533.3300
fumagillol LS411N CTRP1 0.2603 33.3330
fumagillol LS513 CTRP1 0.2603 33.3330
fumagillol MDST8 CTRP1 4.1667 533.3300
fumagillol NCI-H508 CTRP1 4.1667 533.3300
fumagillol RCM-1[HUMANESC] CTRP1 4.1667 533.3300
fumagillol RKO CTRP1 4.1667 533.3300
fumagillol SK-CO-1 CTRP1 0.2603 33.3330
fumagillol SNU-1040 CTRP1 4.1667 533.3300
fumagillol SNU-175 CTRP1 4.1667 533.3300
fumagillol SNU-61 CTRP1 4.1667 533.3300
fumagillol SNU-81 CTRP1 4.1667 533.3300
fumagillol SNU-C2A CTRP1 0.2603 33.3330
fumagillol SNU-C4 CTRP1 4.1667 533.3300
fumagillol SNU-C5 CTRP1 4.1667 533.3300
fumagillol SW403 CTRP1 0.2603 33.3330
fumagillol SW48 CTRP1 0.2603 33.3330
fumagillol SW480 CTRP1 4.1667 533.3300
fumagillol SW620 CTRP1 4.1667 533.3300
fumagillol SW948 CTRP1 4.1667 533.3300
fumagillol HEP-G2 CTRP1 4.1667 533.3300
fumagillol JHH-6 CTRP1 0.2603 33.3330
fumagillol SNU-398 CTRP1 4.1667 533.3300
fumagillol SNU-449 CTRP1 0.2603 33.3330
fumagillol A-549 CTRP1 0.2603 33.3330
fumagillol BEN CTRP1 0.2603 33.3330
fumagillol CAL-12T CTRP1 4.1667 533.3300
fumagillol CALU-3 CTRP1 0.2603 33.3330
fumagillol CALU-6 CTRP1 0.2603 33.3330
fumagillol CHAGO-K-1 CTRP1 0.2603 33.3330
fumagillol COLO668 CTRP1 0.2603 33.3330
fumagillol COLO699 CTRP1 4.1667 533.3300
fumagillol COR-L23 CTRP1 4.1667 533.3300
fumagillol COR-L279 CTRP1 0.2603 33.3330
fumagillol COR-L51 CTRP1 4.1667 533.3300
fumagillol COR-L88 CTRP1 0.2603 33.3330
fumagillol DMS273 CTRP1 0.2603 33.3330
fumagillol DV-90 CTRP1 0.2603 33.3330
fumagillol EBC-1 CTRP1 0.2603 33.3330
fumagillol EPLC-272H CTRP1 0.2603 33.3330
fumagillol HARA[HUMANSQUAMOUSCELLLUNGCARCINOMA] CTRP1 0.2603 33.3330
fumagillol HCC1195 CTRP1 4.1667 533.3300
fumagillol HCC1359 CTRP1 4.1667 533.3300
fumagillol HCC15 CTRP1 4.1667 533.3300
fumagillol HCC1833 CTRP1 4.1667 533.3300
fumagillol HCC2108 CTRP1 4.1667 533.3300
fumagillol HCC2935 CTRP1 4.1667 533.3300
fumagillol HCC33 CTRP1 0.2603 33.3330
fumagillol HCC4006 CTRP1 4.1667 533.3300
fumagillol HCC44 CTRP1 0.2603 33.3330
fumagillol HCC78 CTRP1 0.2603 33.3330
fumagillol HCC827 CTRP1 4.1667 533.3300
fumagillol KNS-62 CTRP1 0.2603 33.3330
fumagillol LC-1-SQ-SF CTRP1 0.2603 33.3330
fumagillol LCLC-103H CTRP1 0.2603 33.3330
fumagillol LCLC-97TM1 CTRP1 0.2603 33.3330
fumagillol LU-65 CTRP1 0.2603 33.3330
fumagillol LU-99 CTRP1 0.2603 33.3330
fumagillol LXF289 CTRP1 0.2603 33.3330
fumagillol NCI-H1048 CTRP1 0.2603 33.3330
fumagillol NCI-H1105 CTRP1 4.1667 533.3300
fumagillol NCI-H1299 CTRP1 0.2603 33.3330
fumagillol NCI-H1355 CTRP1 0.2603 33.3330
fumagillol NCI-H1373 CTRP1 0.2603 33.3330
fumagillol NCI-H1435 CTRP1 0.2603 33.3330
fumagillol NCI-H1437 CTRP1 0.2603 33.3330
fumagillol NCI-H1568 CTRP1 0.2603 33.3330
fumagillol NCI-H1573 CTRP1 0.2603 33.3330
fumagillol NCI-H1666 CTRP1 0.2603 33.3330
fumagillol NCI-H1694 CTRP1 4.1667 533.3300
fumagillol NCI-H1755 CTRP1 4.1667 533.3300
fumagillol NCI-H1781 CTRP1 4.1667 533.3300
fumagillol NCI-H1792 CTRP1 0.2603 33.3330
fumagillol NCI-H1793 CTRP1 0.2603 33.3330
fumagillol NCI-H1836 CTRP1 4.1667 533.3300
fumagillol NCI-H1876 CTRP1 4.1667 533.3300
fumagillol NCI-H1915 CTRP1 0.2603 33.3330
fumagillol NCI-H1930 CTRP1 0.2603 33.3330
fumagillol NCI-H1944 CTRP1 0.2603 33.3330
fumagillol NCI-H1963 CTRP1 4.1667 533.3300
fumagillol NCI-H1975 CTRP1 0.2603 33.3330
fumagillol NCI-H2009 CTRP1 0.2603 33.3330
fumagillol NCI-H2023 CTRP1 4.1667 533.3300
fumagillol NCI-H2029 CTRP1 0.2603 33.3330
fumagillol NCI-H2030 CTRP1 4.1667 533.3300
fumagillol NCI-H2073 CTRP1 4.1667 533.3300
fumagillol NCI-H2081 CTRP1 4.1667 533.3300
fumagillol NCI-H2110 CTRP1 4.1667 533.3300
fumagillol NCI-H2122 CTRP1 4.1667 533.3300
fumagillol NCI-H2126 CTRP1 0.2603 33.3330
fumagillol NCI-H2141 CTRP1 4.1667 533.3300
fumagillol NCI-H2172 CTRP1 4.1667 533.3300
fumagillol NCI-H2286 CTRP1 0.2603 33.3330
fumagillol NCI-H23 CTRP1 0.2603 33.3330
fumagillol NCI-H2342 CTRP1 4.1667 533.3300
fumagillol NCI-H2405 CTRP1 0.2603 33.3330
fumagillol NCI-H3255 CTRP1 4.1667 533.3300
fumagillol NCI-H358 CTRP1 0.2603 33.3330
fumagillol NCI-H441 CTRP1 4.1667 533.3300
fumagillol NCI-H460 CTRP1 4.1667 533.3300
fumagillol NCI-H522 CTRP1 0.2603 33.3330
fumagillol NCI-H596 CTRP1 4.1667 533.3300
fumagillol NCI-H650 CTRP1 0.2603 33.3330
fumagillol NCI-H661 CTRP1 0.2603 33.3330
fumagillol NCI-H727 CTRP1 0.2603 33.3330
fumagillol NCI-H810 CTRP1 0.2603 33.3330
fumagillol NCI-H82 CTRP1 0.2603 33.3330
fumagillol NCI-H841 CTRP1 4.1667 533.3300
fumagillol RERF-LC-KJ CTRP1 0.2603 33.3330
fumagillol SCLC-21H CTRP1 4.1667 533.3300
fumagillol SHP-77 CTRP1 0.2603 33.3330
fumagillol SK-LU-1 CTRP1 4.1667 533.3300
fumagillol SQ-1 CTRP1 4.1667 533.3300
fumagillol T3M-10 CTRP1 4.1667 533.3300
fumagillol VMRC-LCD CTRP1 0.2603 33.3330
fumagillol KYSE-140 CTRP1 0.2603 33.3330
fumagillol KYSE-410 CTRP1 0.2603 33.3330
fumagillol KYSE-450 CTRP1 0.2603 33.3330
fumagillol A2780 CTRP1 4.1667 533.3300
fumagillol CAOV-3 CTRP1 4.1667 533.3300
fumagillol COV318 CTRP1 0.2603 33.3330
fumagillol COV362 CTRP1 4.1667 533.3300
fumagillol COV434 CTRP1 4.1667 533.3300
fumagillol COV644 CTRP1 4.1667 533.3300
fumagillol EFO-21 CTRP1 0.2603 33.3330
fumagillol EFO-27 CTRP1 4.1667 533.3300
fumagillol HEYA8 CTRP1 0.2603 33.3330
fumagillol IGROV-1 CTRP1 4.1667 533.3300
fumagillol JHOC-5 CTRP1 4.1667 533.3300
fumagillol JHOM-1 CTRP1 4.1667 533.3300
fumagillol JHOS-4 CTRP1 0.2603 33.3330
fumagillol OAW42 CTRP1 4.1667 533.3300
fumagillol OV7 CTRP1 4.1667 533.3300
fumagillol OV-90 CTRP1 4.1667 533.3300
fumagillol OVCAR-4 CTRP1 4.1667 533.3300
fumagillol OVCAR-8 CTRP1 4.1667 533.3300
fumagillol OVK18 CTRP1 4.1667 533.3300
fumagillol OVKATE CTRP1 4.1667 533.3300
fumagillol OVMANA CTRP1 0.2603 33.3330
fumagillol RKN CTRP1 4.1667 533.3300
fumagillol RMG-I CTRP1 4.1667 533.3300
fumagillol RMUG-S CTRP1 4.1667 533.3300
fumagillol SK-OV-3 CTRP1 0.2603 33.3330
fumagillol SNU-840 CTRP1 4.1667 533.3300
fumagillol TYK-NU CTRP1 4.1667 533.3300
fumagillol CAPAN-2 CTRP1 0.2603 33.3330
fumagillol CFPAC-1 CTRP1 0.2603 33.3330
fumagillol HPAC CTRP1 0.2603 33.3330
fumagillol HUP-T4 CTRP1 0.2603 33.3330
fumagillol KP-3 CTRP1 0.2603 33.3330
fumagillol PANC03.27 CTRP1 0.2603 33.3330
fumagillol PANC10.05 CTRP1 0.2603 33.3330
fumagillol PATU8902 CTRP1 0.2603 33.3330
fumagillol QGP-1 CTRP1 0.2603 33.3330
fumagillol SUIT-2 CTRP1 0.2603 33.3330
fumagillol MSTO-211H CTRP1 0.2603 33.3330
fumagillol NCI-H2052 CTRP1 0.2603 33.3330
fumagillol NCI-H28 CTRP1 0.2603 33.3330
fumagillol MIAPACA-3 CTRP1 0.2603 33.3330
fumagillol A-375 CTRP1 4.1667 533.3300
fumagillol COLO741 CTRP1 0.2603 33.3330
fumagillol G-361 CTRP1 0.2603 33.3330
fumagillol HS852.T CTRP1 0.2603 33.3330
fumagillol HS936.T CTRP1 0.2603 33.3330
fumagillol HS944.T CTRP1 0.2603 33.3330
fumagillol SK-MEL-1 CTRP1 4.1667 533.3300
fumagillol SK-MEL-28 CTRP1 4.1667 533.3300
fumagillol SK-MEL-5 CTRP1 4.1667 533.3300
fumagillol G-401 CTRP1 0.2603 33.3330
fumagillol HT-1080 CTRP1 4.1667 533.3300
fumagillol AGS CTRP1 4.1667 533.3300
fumagillol FU97 CTRP1 0.2603 33.3330
fumagillol KE-97 CTRP1 0.2603 33.3330
fumagillol MKN7 CTRP1 0.2603 33.3330
fumagillol MKN74 CTRP1 0.2603 33.3330
fumagillol NUGC-4 CTRP1 0.2603 33.3330
fumagillol SH-10-TC CTRP1 0.2603 33.3330
fumagillol HSC-2 CTRP1 0.2603 33.3330
fumagillol SCC-9 CTRP1 4.1667 533.3300
fumagillol 5637 CTRP1 0.2603 33.3330
fumagillol HT-1376 CTRP1 0.2603 33.3330
fumagillol KMBC-2 CTRP1 0.2603 33.3330
fumagillol RT-4 CTRP1 0.2603 33.3330
fumagillol UM-UC-3 CTRP1 0.2603 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.