Drug : P-0850

CTRP1 Name : P-0850

Dataset : All
Synonyms :
Targets : BRAF
Pathways : inhibitor of BRAF V600E;analog of vemurafenib (PLX-4032)

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
P-0850 U2OS CTRP1 0.2604 33.3330
P-0850 MCF-7 CTRP1 0.2604 33.3330
P-0850 GAMG CTRP1 0.2603 33.3330
P-0850 LN-229 CTRP1 0.2604 33.3330
P-0850 SF295 CTRP1 0.2603 33.3330
P-0850 HEC-108 CTRP1 0.2603 33.3330
P-0850 HEC-151 CTRP1 0.2604 33.3330
P-0850 HEC-251 CTRP1 0.2603 33.3330
P-0850 HEC-265 CTRP1 0.2603 33.3330
P-0850 HEC-59 CTRP1 0.2603 33.3330
P-0850 HEC-6 CTRP1 0.2603 33.3330
P-0850 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
P-0850 JHUEM-2 CTRP1 0.2604 33.3330
P-0850 KLE CTRP1 0.2603 33.3330
P-0850 MFE-319 CTRP1 0.2603 33.3330
P-0850 SNG-M CTRP1 0.2603 33.3330
P-0850 AMO1 CTRP1 0.2604 33.3330
P-0850 BL-70 CTRP1 0.2603 33.3330
P-0850 EJM CTRP1 0.2604 33.3330
P-0850 GDM-1 CTRP1 0.2604 33.3330
P-0850 HT CTRP1 0.2603 33.3330
P-0850 KMS-11 CTRP1 0.2604 33.3330
P-0850 KU812 CTRP1 0.2603 33.3330
P-0850 LP-1 CTRP1 0.2604 33.3330
P-0850 MC116 CTRP1 0.2603 33.3330
P-0850 MOLM-16 CTRP1 0.2604 33.3330
P-0850 NOMO-1 CTRP1 0.2604 33.3330
P-0850 NU-DUL-1 CTRP1 0.2604 33.3330
P-0850 OCI-AML-3 CTRP1 0.2604 33.3330
P-0850 OCI-LY10 CTRP1 0.2604 33.3330
P-0850 P3HR-1 CTRP1 0.2603 33.3330
P-0850 PL21 CTRP1 0.2604 33.3330
P-0850 RPMI-8226 CTRP1 0.2604 33.3330
P-0850 SKM-1 CTRP1 0.2604 33.3330
P-0850 SU-DHL-4 CTRP1 0.2604 33.3330
P-0850 SU-DHL-5 CTRP1 0.2604 33.3330
P-0850 THP-1 CTRP1 0.2604 33.3330
P-0850 U-937 CTRP1 0.2604 33.3330
P-0850 WSU-DLCL2 CTRP1 0.2604 33.3330
P-0850 RCC10RGB CTRP1 0.2604 33.3330
P-0850 VMRC-RCW CTRP1 0.2603 33.3330
P-0850 CL-34 CTRP1 0.2604 33.3330
P-0850 CL-40 CTRP1 0.2604 33.3330
P-0850 COLO320 CTRP1 0.2604 33.3330
P-0850 COLO678 CTRP1 0.2604 33.3330
P-0850 CW-2 CTRP1 0.2604 33.3330
P-0850 HCT116 CTRP1 0.2604 33.3330
P-0850 HCT8 CTRP1 0.2604 33.3330
P-0850 HT115 CTRP1 0.2604 33.3330
P-0850 HT-29 CTRP1 0.2604 33.3330
P-0850 HT-55 CTRP1 0.2604 33.3330
P-0850 KM12 CTRP1 0.2604 33.3330
P-0850 LOVO CTRP1 0.2604 33.3330
P-0850 LS123 CTRP1 0.2604 33.3330
P-0850 LS180 CTRP1 0.2604 33.3330
P-0850 MDST8 CTRP1 0.2604 33.3330
P-0850 NCI-H508 CTRP1 0.2604 33.3330
P-0850 RCM-1[HUMANESC] CTRP1 0.2604 33.3330
P-0850 RKO CTRP1 0.2604 33.3330
P-0850 SNU-1040 CTRP1 0.2604 33.3330
P-0850 SNU-175 CTRP1 0.2604 33.3330
P-0850 SNU-61 CTRP1 0.2604 33.3330
P-0850 SNU-81 CTRP1 0.2604 33.3330
P-0850 SNU-C2A CTRP1 0.2603 33.3330
P-0850 SNU-C4 CTRP1 0.2604 33.3330
P-0850 SNU-C5 CTRP1 0.2604 33.3330
P-0850 SW403 CTRP1 0.2603 33.3330
P-0850 SW480 CTRP1 0.2604 33.3330
P-0850 SW620 CTRP1 0.2604 33.3330
P-0850 SW948 CTRP1 0.2604 33.3330
P-0850 HEP-G2 CTRP1 0.2604 33.3330
P-0850 JHH-6 CTRP1 0.2603 33.3330
P-0850 SNU-398 CTRP1 0.2604 33.3330
P-0850 SNU-449 CTRP1 0.2603 33.3330
P-0850 A-549 CTRP1 0.2603 33.3330
P-0850 CAL-12T CTRP1 0.2604 33.3330
P-0850 CALU-3 CTRP1 0.2603 33.3330
P-0850 CALU-6 CTRP1 0.2603 33.3330
P-0850 CHAGO-K-1 CTRP1 0.2603 33.3330
P-0850 COLO668 CTRP1 0.2603 33.3330
P-0850 COLO699 CTRP1 0.2604 33.3330
P-0850 COR-L23 CTRP1 0.2604 33.3330
P-0850 COR-L279 CTRP1 0.2603 33.3330
P-0850 COR-L51 CTRP1 0.2604 33.3330
P-0850 COR-L88 CTRP1 0.2603 33.3330
P-0850 DMS273 CTRP1 0.2603 33.3330
P-0850 EPLC-272H CTRP1 0.2603 33.3330
P-0850 HCC1195 CTRP1 0.2604 33.3330
P-0850 HCC1359 CTRP1 0.2604 33.3330
P-0850 HCC15 CTRP1 0.2604 33.3330
P-0850 HCC1833 CTRP1 0.2604 33.3330
P-0850 HCC2108 CTRP1 0.2604 33.3330
P-0850 HCC2935 CTRP1 0.2604 33.3330
P-0850 HCC4006 CTRP1 0.2604 33.3330
P-0850 HCC827 CTRP1 0.2604 33.3330
P-0850 KNS-62 CTRP1 0.2603 33.3330
P-0850 LCLC-97TM1 CTRP1 0.2603 33.3330
P-0850 LXF289 CTRP1 0.2603 33.3330
P-0850 NCI-H1048 CTRP1 0.2603 33.3330
P-0850 NCI-H1105 CTRP1 0.2604 33.3330
P-0850 NCI-H1299 CTRP1 0.2603 33.3330
P-0850 NCI-H1355 CTRP1 0.2603 33.3330
P-0850 NCI-H1435 CTRP1 0.2603 33.3330
P-0850 NCI-H1437 CTRP1 0.2603 33.3330
P-0850 NCI-H1568 CTRP1 0.2603 33.3330
P-0850 NCI-H1573 CTRP1 0.2603 33.3330
P-0850 NCI-H1666 CTRP1 0.2603 33.3330
P-0850 NCI-H1694 CTRP1 0.2604 33.3330
P-0850 NCI-H1755 CTRP1 0.2604 33.3330
P-0850 NCI-H1781 CTRP1 0.2604 33.3330
P-0850 NCI-H1792 CTRP1 0.2603 33.3330
P-0850 NCI-H1836 CTRP1 0.2604 33.3330
P-0850 NCI-H1876 CTRP1 0.2604 33.3330
P-0850 NCI-H1915 CTRP1 0.2603 33.3330
P-0850 NCI-H1930 CTRP1 0.2603 33.3330
P-0850 NCI-H1944 CTRP1 0.2603 33.3330
P-0850 NCI-H1963 CTRP1 0.2604 33.3330
P-0850 NCI-H1975 CTRP1 0.2603 33.3330
P-0850 NCI-H2009 CTRP1 0.2603 33.3330
P-0850 NCI-H2023 CTRP1 0.2604 33.3330
P-0850 NCI-H2029 CTRP1 0.2603 33.3330
P-0850 NCI-H2030 CTRP1 0.2604 33.3330
P-0850 NCI-H2073 CTRP1 0.2604 33.3330
P-0850 NCI-H2081 CTRP1 0.2604 33.3330
P-0850 NCI-H2110 CTRP1 0.2604 33.3330
P-0850 NCI-H2122 CTRP1 0.2604 33.3330
P-0850 NCI-H2141 CTRP1 0.2604 33.3330
P-0850 NCI-H2172 CTRP1 0.2604 33.3330
P-0850 NCI-H2286 CTRP1 0.2603 33.3330
P-0850 NCI-H23 CTRP1 0.2603 33.3330
P-0850 NCI-H2342 CTRP1 0.2604 33.3330
P-0850 NCI-H2405 CTRP1 0.2603 33.3330
P-0850 NCI-H3255 CTRP1 0.2604 33.3330
P-0850 NCI-H441 CTRP1 0.2604 33.3330
P-0850 NCI-H460 CTRP1 0.2604 33.3330
P-0850 NCI-H596 CTRP1 0.2604 33.3330
P-0850 NCI-H650 CTRP1 0.2603 33.3330
P-0850 NCI-H810 CTRP1 0.2603 33.3330
P-0850 NCI-H82 CTRP1 0.2603 33.3330
P-0850 NCI-H841 CTRP1 0.2604 33.3330
P-0850 RERF-LC-KJ CTRP1 0.2603 33.3330
P-0850 SCLC-21H CTRP1 0.2604 33.3330
P-0850 SK-LU-1 CTRP1 0.2604 33.3330
P-0850 SQ-1 CTRP1 0.2604 33.3330
P-0850 T3M-10 CTRP1 0.2604 33.3330
P-0850 VMRC-LCD CTRP1 0.2603 33.3330
P-0850 KYSE-140 CTRP1 0.2603 33.3330
P-0850 KYSE-410 CTRP1 0.2603 33.3330
P-0850 KYSE-450 CTRP1 0.2603 33.3330
P-0850 A2780 CTRP1 0.2604 33.3330
P-0850 CAOV-3 CTRP1 0.2604 33.3330
P-0850 COV318 CTRP1 0.2603 33.3330
P-0850 COV362 CTRP1 0.2604 33.3330
P-0850 COV434 CTRP1 0.2604 33.3330
P-0850 COV644 CTRP1 0.2604 33.3330
P-0850 EFO-21 CTRP1 0.2603 33.3330
P-0850 EFO-27 CTRP1 0.2604 33.3330
P-0850 HEYA8 CTRP1 0.2603 33.3330
P-0850 IGROV-1 CTRP1 0.2604 33.3330
P-0850 JHOC-5 CTRP1 0.2604 33.3330
P-0850 JHOM-1 CTRP1 0.2604 33.3330
P-0850 JHOS-4 CTRP1 0.2603 33.3330
P-0850 OAW42 CTRP1 0.2604 33.3330
P-0850 OV7 CTRP1 0.2604 33.3330
P-0850 OV-90 CTRP1 0.2604 33.3330
P-0850 OVCAR-4 CTRP1 0.2604 33.3330
P-0850 OVCAR-8 CTRP1 0.2604 33.3330
P-0850 OVK18 CTRP1 0.2604 33.3330
P-0850 OVKATE CTRP1 0.2604 33.3330
P-0850 OVMANA CTRP1 0.2603 33.3330
P-0850 RKN CTRP1 0.2604 33.3330
P-0850 RMG-I CTRP1 0.2604 33.3330
P-0850 RMUG-S CTRP1 0.2604 33.3330
P-0850 SK-OV-3 CTRP1 0.2603 33.3330
P-0850 SNU-840 CTRP1 0.2604 33.3330
P-0850 TYK-NU CTRP1 0.2604 33.3330
P-0850 CAPAN-2 CTRP1 0.2603 33.3330
P-0850 HUP-T4 CTRP1 0.2603 33.3330
P-0850 KP-3 CTRP1 0.2603 33.3330
P-0850 PANC03.27 CTRP1 0.2603 33.3330
P-0850 PATU8902 CTRP1 0.2603 33.3330
P-0850 QGP-1 CTRP1 0.2603 33.3330
P-0850 SUIT-2 CTRP1 0.2603 33.3330
P-0850 MSTO-211H CTRP1 0.2603 33.3330
P-0850 NCI-H2052 CTRP1 0.2603 33.3330
P-0850 NCI-H28 CTRP1 0.2603 33.3330
P-0850 MIAPACA-3 CTRP1 0.2603 33.3330
P-0850 A-375 CTRP1 0.2604 33.3330
P-0850 G-361 CTRP1 0.2603 33.3330
P-0850 HS852.T CTRP1 0.2603 33.3330
P-0850 HS936.T CTRP1 0.2603 33.3330
P-0850 HS944.T CTRP1 0.2603 33.3330
P-0850 SK-MEL-1 CTRP1 0.2604 33.3330
P-0850 SK-MEL-28 CTRP1 0.2604 33.3330
P-0850 SK-MEL-5 CTRP1 0.2604 33.3330
P-0850 G-401 CTRP1 0.2603 33.3330
P-0850 HT-1080 CTRP1 0.2604 33.3330
P-0850 AGS CTRP1 0.2604 33.3330
P-0850 FU97 CTRP1 0.2603 33.3330
P-0850 KE-97 CTRP1 0.2603 33.3330
P-0850 MKN7 CTRP1 0.2603 33.3330
P-0850 MKN74 CTRP1 0.2603 33.3330
P-0850 NUGC-4 CTRP1 0.2603 33.3330
P-0850 SH-10-TC CTRP1 0.2603 33.3330
P-0850 HSC-2 CTRP1 0.2603 33.3330
P-0850 SCC-9 CTRP1 0.2604 33.3330
P-0850 5637 CTRP1 0.2603 33.3330
P-0850 HT-1376 CTRP1 0.2603 33.3330
P-0850 KMBC-2 CTRP1 0.2603 33.3330
P-0850 RT-4 CTRP1 0.2603 33.3330
P-0850 UM-UC-3 CTRP1 0.2603 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.