Drug : Compound 10B
CTRP1 Name
: Compound 10b
Dataset : All
Synonyms :
Targets : MAP3K8
Pathways : inhibitor of MAP3K8 (TPL2/COT)
Information Cards
Click to show/hide information cards below or download all drug response information.
Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.
Experimental information
Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.
| Drug name | Cellosaurus ID | Original Dataset(s) | Min Dose | Max Dose | Dose-response |
|---|---|---|---|---|---|
| Compound 10b | U2OS | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | MCF-7 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | GAMG | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LN-229 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SF295 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HEC-108 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HEC-151 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HEC-251 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HEC-265 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HEC-59 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HEC-6 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | ISHIKAWA(HERAKLIO)02ER- | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | JHUEM-2 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | KLE | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | MFE-319 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SNG-M | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | AMO1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | BL-70 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | EJM | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | GDM-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HT | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | KMS-11 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | KU812 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LP-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | MC116 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | MOLM-16 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NOMO-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NU-DUL-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OCI-AML-3 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OCI-LY10 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | P3HR-1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | PL21 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | RPMI-8226 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SKM-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SU-DHL-4 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SU-DHL-5 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | THP-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | U-937 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | WSU-DLCL2 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | RCC10RGB | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | VMRC-RCW | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | C2BBE1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | CL-34 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | CL-40 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COLO205 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | COLO320 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COLO678 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | CW-2 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | DLD-1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | GP2D | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HCT116 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCT8 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HT115 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HT-29 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HT-55 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | KM12 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | LOVO | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | LS123 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | LS180 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | LS411N | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LS513 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | MDST8 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H508 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | RCM-1[HUMANESC] | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | RKO | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SK-CO-1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SNU-1040 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SNU-175 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SNU-61 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SNU-81 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SNU-C2A | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SNU-C4 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SNU-C5 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SW403 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SW48 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SW480 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SW620 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SW948 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HEP-G2 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | JHH-6 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SNU-398 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SNU-449 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | A-549 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | BEN | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | CAL-12T | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | CALU-3 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | CALU-6 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | CHAGO-K-1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | COLO668 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | COLO699 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COR-L23 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COR-L279 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | COR-L51 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COR-L88 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | DMS273 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | DV-90 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | EBC-1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | EPLC-272H | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HARA[HUMANSQUAMOUSCELLLUNGCARCINOMA] | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HCC1195 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCC1359 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCC15 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCC1833 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCC2108 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCC2935 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCC33 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HCC4006 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HCC44 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HCC78 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HCC827 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | KNS-62 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LC-1-SQ-SF | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LCLC-103H | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LCLC-97TM1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LU-65 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LU-99 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | LXF289 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1048 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1105 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H1299 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1355 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1373 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1435 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1437 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1568 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1573 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1666 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1694 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H1755 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H1781 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H1792 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1793 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1836 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H1876 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H1915 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1930 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1944 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H1963 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H1975 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H2009 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H2023 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2029 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H2030 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2073 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2081 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2110 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2122 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2126 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H2141 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2172 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2286 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H23 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H2342 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H2405 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H3255 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H358 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H441 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H460 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H522 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H596 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | NCI-H650 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H661 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H727 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H810 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H82 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H841 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | RERF-LC-KJ | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SCLC-21H | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SHP-77 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SK-LU-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SQ-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | T3M-10 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | VMRC-LCD | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | KYSE-140 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | KYSE-410 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | KYSE-450 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | A2780 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | CAOV-3 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COV318 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | COV362 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COV434 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COV644 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | EFO-21 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | EFO-27 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | HEYA8 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | IGROV-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | JHOC-5 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | JHOM-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | JHOS-4 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | OAW42 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OV7 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OV-90 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OVCAR-4 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OVCAR-8 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OVK18 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OVKATE | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | OVMANA | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | RKN | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | RMG-I | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | RMUG-S | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SK-OV-3 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SNU-840 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | TYK-NU | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | CAPAN-2 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | CFPAC-1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HPAC | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HUP-T4 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | KP-3 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | PANC03.27 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | PANC10.05 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | PATU8902 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | QGP-1 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SUIT-2 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | MSTO-211H | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H2052 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NCI-H28 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | MIAPACA-3 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | A-375 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | COLO741 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | G-361 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HS852.T | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HS936.T | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HS944.T | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SK-MEL-1 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SK-MEL-28 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | SK-MEL-5 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | G-401 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HT-1080 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | AGS | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | FU97 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | KE-97 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | MKN7 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | MKN74 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | NUGC-4 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SH-10-TC | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HSC-2 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | SCC-9 | CTRP1 | 1.1562 | 148.0000 |
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| Compound 10b | 5637 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | HT-1376 | CTRP1 | 0.2890 | 37.0000 |
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| Compound 10b | KMBC-2 | CTRP1 | 0.2890 | 37.0000 |
|
| Compound 10b | RT-4 | CTRP1 | 0.2890 | 37.0000 |
|
| Compound 10b | UM-UC-3 | CTRP1 | 0.2890 | 37.0000 |
|
IC50
IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.
Cell lines with highest and lowest IC50
Cell lines with highest and lowest IC50
IC90
IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.
Cell lines with highest and lowest IC90
Cell lines with highest and lowest IC90
AUC
AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.
Cell lines with highest and lowest AUC
Cell lines with highest and lowest AUC
Associated Genes (Mutation)
Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from
pancan data.
Associated Genes (Gene Expression)
Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from
pancan data.