Drug : Chembl399379

CTRP1 Name : CHEMBL399379

Dataset : All
Synonyms :
Targets : ACLY
Pathways : inhibitor of ATP citrate synthase

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
CHEMBL399379 MCF-7 CTRP1 2.0833 266.6700
CHEMBL399379 GAMG CTRP1 0.2603 33.3330
CHEMBL399379 LN-229 CTRP1 2.0833 266.6700
CHEMBL399379 SF295 CTRP1 0.2603 33.3330
CHEMBL399379 HEC-108 CTRP1 0.2603 33.3330
CHEMBL399379 HEC-151 CTRP1 2.0833 266.6700
CHEMBL399379 HEC-251 CTRP1 0.2603 33.3330
CHEMBL399379 HEC-265 CTRP1 0.2603 33.3330
CHEMBL399379 HEC-59 CTRP1 0.2603 33.3330
CHEMBL399379 HEC-6 CTRP1 0.2603 33.3330
CHEMBL399379 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
CHEMBL399379 JHUEM-2 CTRP1 2.0833 266.6700
CHEMBL399379 KLE CTRP1 0.2603 33.3330
CHEMBL399379 MFE-319 CTRP1 0.2603 33.3330
CHEMBL399379 SNG-M CTRP1 0.2603 33.3330
CHEMBL399379 AMO1 CTRP1 2.0833 266.6700
CHEMBL399379 BL-70 CTRP1 0.2603 33.3330
CHEMBL399379 EJM CTRP1 2.0833 266.6700
CHEMBL399379 GDM-1 CTRP1 2.0833 266.6700
CHEMBL399379 HT CTRP1 0.2603 33.3330
CHEMBL399379 KMS-11 CTRP1 2.0833 266.6700
CHEMBL399379 KU812 CTRP1 0.2603 33.3330
CHEMBL399379 LP-1 CTRP1 2.0833 266.6700
CHEMBL399379 MC116 CTRP1 0.2603 33.3330
CHEMBL399379 MOLM-16 CTRP1 2.0833 266.6700
CHEMBL399379 NOMO-1 CTRP1 2.0833 266.6700
CHEMBL399379 NU-DUL-1 CTRP1 2.0833 266.6700
CHEMBL399379 OCI-AML-3 CTRP1 2.0833 266.6700
CHEMBL399379 OCI-LY10 CTRP1 2.0833 266.6700
CHEMBL399379 P3HR-1 CTRP1 0.2603 33.3330
CHEMBL399379 PL21 CTRP1 2.0833 266.6700
CHEMBL399379 RPMI-8226 CTRP1 2.0833 266.6700
CHEMBL399379 SKM-1 CTRP1 2.0833 266.6700
CHEMBL399379 SU-DHL-4 CTRP1 2.0833 266.6700
CHEMBL399379 SU-DHL-5 CTRP1 2.0833 266.6700
CHEMBL399379 THP-1 CTRP1 2.0833 266.6700
CHEMBL399379 U-937 CTRP1 2.0833 266.6700
CHEMBL399379 WSU-DLCL2 CTRP1 2.0833 266.6700
CHEMBL399379 RCC10RGB CTRP1 2.0833 266.6700
CHEMBL399379 VMRC-RCW CTRP1 0.2603 33.3330
CHEMBL399379 C2BBE1 CTRP1 0.2603 33.3330
CHEMBL399379 CL-34 CTRP1 2.0833 266.6700
CHEMBL399379 CL-40 CTRP1 2.0833 266.6700
CHEMBL399379 COLO205 CTRP1 0.2603 33.3330
CHEMBL399379 COLO320 CTRP1 2.0833 266.6700
CHEMBL399379 COLO678 CTRP1 2.0833 266.6700
CHEMBL399379 CW-2 CTRP1 2.0833 266.6700
CHEMBL399379 DLD-1 CTRP1 0.2603 33.3330
CHEMBL399379 GP2D CTRP1 0.2603 33.3330
CHEMBL399379 HCT116 CTRP1 2.0833 266.6700
CHEMBL399379 HCT8 CTRP1 2.0833 266.6700
CHEMBL399379 HT115 CTRP1 2.0833 266.6700
CHEMBL399379 HT-29 CTRP1 2.0833 266.6700
CHEMBL399379 HT-55 CTRP1 2.0833 266.6700
CHEMBL399379 KM12 CTRP1 2.0833 266.6700
CHEMBL399379 LOVO CTRP1 2.0833 266.6700
CHEMBL399379 LS123 CTRP1 2.0833 266.6700
CHEMBL399379 LS180 CTRP1 2.0833 266.6700
CHEMBL399379 LS411N CTRP1 0.2603 33.3330
CHEMBL399379 LS513 CTRP1 0.2603 33.3330
CHEMBL399379 MDST8 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H508 CTRP1 2.0833 266.6700
CHEMBL399379 RCM-1[HUMANESC] CTRP1 2.0833 266.6700
CHEMBL399379 RKO CTRP1 2.0833 266.6700
CHEMBL399379 SK-CO-1 CTRP1 0.2603 33.3330
CHEMBL399379 SNU-1040 CTRP1 2.0833 266.6700
CHEMBL399379 SNU-175 CTRP1 2.0833 266.6700
CHEMBL399379 SNU-61 CTRP1 2.0833 266.6700
CHEMBL399379 SNU-81 CTRP1 2.0833 266.6700
CHEMBL399379 SNU-C2A CTRP1 0.2603 33.3330
CHEMBL399379 SNU-C4 CTRP1 2.0833 266.6700
CHEMBL399379 SNU-C5 CTRP1 2.0833 266.6700
CHEMBL399379 SW403 CTRP1 0.2603 33.3330
CHEMBL399379 SW48 CTRP1 0.2603 33.3330
CHEMBL399379 SW480 CTRP1 2.0833 266.6700
CHEMBL399379 SW620 CTRP1 2.0833 266.6700
CHEMBL399379 SW948 CTRP1 2.0833 266.6700
CHEMBL399379 HEP-G2 CTRP1 2.0833 266.6700
CHEMBL399379 JHH-6 CTRP1 0.2603 33.3330
CHEMBL399379 SNU-398 CTRP1 2.0833 266.6700
CHEMBL399379 SNU-449 CTRP1 0.2603 33.3330
CHEMBL399379 A-549 CTRP1 0.2603 33.3330
CHEMBL399379 BEN CTRP1 0.2603 33.3330
CHEMBL399379 CAL-12T CTRP1 2.0833 266.6700
CHEMBL399379 CALU-3 CTRP1 0.2603 33.3330
CHEMBL399379 CALU-6 CTRP1 0.2603 33.3330
CHEMBL399379 CHAGO-K-1 CTRP1 0.2603 33.3330
CHEMBL399379 COLO668 CTRP1 0.2603 33.3330
CHEMBL399379 COLO699 CTRP1 2.0833 266.6700
CHEMBL399379 COR-L23 CTRP1 2.0833 266.6700
CHEMBL399379 COR-L279 CTRP1 0.2603 33.3330
CHEMBL399379 COR-L51 CTRP1 2.0833 266.6700
CHEMBL399379 COR-L88 CTRP1 0.2603 33.3330
CHEMBL399379 DMS273 CTRP1 0.2603 33.3330
CHEMBL399379 DV-90 CTRP1 0.2603 33.3330
CHEMBL399379 EBC-1 CTRP1 0.2603 33.3330
CHEMBL399379 EPLC-272H CTRP1 0.2603 33.3330
CHEMBL399379 HARA[HUMANSQUAMOUSCELLLUNGCARCINOMA] CTRP1 0.2603 33.3330
CHEMBL399379 HCC1195 CTRP1 2.0833 266.6700
CHEMBL399379 HCC1359 CTRP1 2.0833 266.6700
CHEMBL399379 HCC15 CTRP1 2.0833 266.6700
CHEMBL399379 HCC1833 CTRP1 2.0833 266.6700
CHEMBL399379 HCC2108 CTRP1 2.0833 266.6700
CHEMBL399379 HCC2935 CTRP1 2.0833 266.6700
CHEMBL399379 HCC33 CTRP1 0.2603 33.3330
CHEMBL399379 HCC4006 CTRP1 2.0833 266.6700
CHEMBL399379 HCC44 CTRP1 0.2603 33.3330
CHEMBL399379 HCC78 CTRP1 0.2603 33.3330
CHEMBL399379 HCC827 CTRP1 2.0833 266.6700
CHEMBL399379 KNS-62 CTRP1 0.2603 33.3330
CHEMBL399379 LC-1-SQ-SF CTRP1 0.2603 33.3330
CHEMBL399379 LCLC-103H CTRP1 0.2603 33.3330
CHEMBL399379 LCLC-97TM1 CTRP1 0.2603 33.3330
CHEMBL399379 LU-65 CTRP1 0.2603 33.3330
CHEMBL399379 LU-99 CTRP1 0.2603 33.3330
CHEMBL399379 LXF289 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1048 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1105 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H1299 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1355 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1373 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1435 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1437 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1568 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1573 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1666 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1694 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H1755 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H1781 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H1792 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1793 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1836 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H1876 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H1915 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1930 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1944 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H1963 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H1975 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H2009 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H2023 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2029 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H2030 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2073 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2081 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2110 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2122 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2126 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H2141 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2172 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2286 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H23 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H2342 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H2405 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H3255 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H358 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H441 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H460 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H522 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H596 CTRP1 2.0833 266.6700
CHEMBL399379 NCI-H650 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H661 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H727 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H810 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H82 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H841 CTRP1 2.0833 266.6700
CHEMBL399379 RERF-LC-KJ CTRP1 0.2603 33.3330
CHEMBL399379 SCLC-21H CTRP1 2.0833 266.6700
CHEMBL399379 SHP-77 CTRP1 0.2603 33.3330
CHEMBL399379 SK-LU-1 CTRP1 2.0833 266.6700
CHEMBL399379 SQ-1 CTRP1 2.0833 266.6700
CHEMBL399379 T3M-10 CTRP1 2.0833 266.6700
CHEMBL399379 VMRC-LCD CTRP1 0.2603 33.3330
CHEMBL399379 KYSE-140 CTRP1 0.2603 33.3330
CHEMBL399379 KYSE-410 CTRP1 0.2603 33.3330
CHEMBL399379 KYSE-450 CTRP1 0.2603 33.3330
CHEMBL399379 A2780 CTRP1 2.0833 266.6700
CHEMBL399379 CAOV-3 CTRP1 2.0833 266.6700
CHEMBL399379 COV318 CTRP1 0.2603 33.3330
CHEMBL399379 COV362 CTRP1 2.0833 266.6700
CHEMBL399379 COV434 CTRP1 2.0833 266.6700
CHEMBL399379 COV644 CTRP1 2.0833 266.6700
CHEMBL399379 EFO-21 CTRP1 0.2603 33.3330
CHEMBL399379 EFO-27 CTRP1 2.0833 266.6700
CHEMBL399379 HEYA8 CTRP1 0.2603 33.3330
CHEMBL399379 IGROV-1 CTRP1 2.0833 266.6700
CHEMBL399379 JHOC-5 CTRP1 2.0833 266.6700
CHEMBL399379 JHOM-1 CTRP1 2.0833 266.6700
CHEMBL399379 JHOS-4 CTRP1 0.2603 33.3330
CHEMBL399379 OAW42 CTRP1 2.0833 266.6700
CHEMBL399379 OV7 CTRP1 2.0833 266.6700
CHEMBL399379 OV-90 CTRP1 2.0833 266.6700
CHEMBL399379 OVCAR-4 CTRP1 2.0833 266.6700
CHEMBL399379 OVCAR-8 CTRP1 2.0833 266.6700
CHEMBL399379 OVK18 CTRP1 2.0833 266.6700
CHEMBL399379 OVKATE CTRP1 2.0833 266.6700
CHEMBL399379 OVMANA CTRP1 0.2603 33.3330
CHEMBL399379 RKN CTRP1 2.0833 266.6700
CHEMBL399379 RMG-I CTRP1 2.0833 266.6700
CHEMBL399379 RMUG-S CTRP1 2.0833 266.6700
CHEMBL399379 SK-OV-3 CTRP1 0.2603 33.3330
CHEMBL399379 SNU-840 CTRP1 2.0833 266.6700
CHEMBL399379 TYK-NU CTRP1 2.0833 266.6700
CHEMBL399379 CAPAN-2 CTRP1 0.2603 33.3330
CHEMBL399379 CFPAC-1 CTRP1 0.2603 33.3330
CHEMBL399379 HPAC CTRP1 0.2603 33.3330
CHEMBL399379 HUP-T4 CTRP1 0.2603 33.3330
CHEMBL399379 KP-3 CTRP1 0.2603 33.3330
CHEMBL399379 PANC03.27 CTRP1 0.2603 33.3330
CHEMBL399379 PANC10.05 CTRP1 0.2603 33.3330
CHEMBL399379 PATU8902 CTRP1 0.2603 33.3330
CHEMBL399379 QGP-1 CTRP1 0.2603 33.3330
CHEMBL399379 SUIT-2 CTRP1 0.2603 33.3330
CHEMBL399379 MSTO-211H CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H2052 CTRP1 0.2603 33.3330
CHEMBL399379 NCI-H28 CTRP1 0.2603 33.3330
CHEMBL399379 MIAPACA-3 CTRP1 0.2603 33.3330
CHEMBL399379 A-375 CTRP1 2.0833 266.6700
CHEMBL399379 COLO741 CTRP1 0.2603 33.3330
CHEMBL399379 G-361 CTRP1 0.2603 33.3330
CHEMBL399379 HS852.T CTRP1 0.2603 33.3330
CHEMBL399379 HS936.T CTRP1 0.2603 33.3330
CHEMBL399379 HS944.T CTRP1 0.2603 33.3330
CHEMBL399379 SK-MEL-1 CTRP1 2.0833 266.6700
CHEMBL399379 SK-MEL-28 CTRP1 2.0833 266.6700
CHEMBL399379 SK-MEL-5 CTRP1 2.0833 266.6700
CHEMBL399379 G-401 CTRP1 0.2603 33.3330
CHEMBL399379 HT-1080 CTRP1 2.0833 266.6700
CHEMBL399379 AGS CTRP1 2.0833 266.6700
CHEMBL399379 FU97 CTRP1 0.2603 33.3330
CHEMBL399379 KE-97 CTRP1 0.2603 33.3330
CHEMBL399379 MKN7 CTRP1 0.2603 33.3330
CHEMBL399379 MKN74 CTRP1 0.2603 33.3330
CHEMBL399379 NUGC-4 CTRP1 0.2603 33.3330
CHEMBL399379 SH-10-TC CTRP1 0.2603 33.3330
CHEMBL399379 HSC-2 CTRP1 0.2603 33.3330
CHEMBL399379 SCC-9 CTRP1 2.0833 266.6700
CHEMBL399379 5637 CTRP1 0.2603 33.3330
CHEMBL399379 HT-1376 CTRP1 0.2603 33.3330
CHEMBL399379 KMBC-2 CTRP1 0.2603 33.3330
CHEMBL399379 RT-4 CTRP1 0.2603 33.3330
CHEMBL399379 UM-UC-3 CTRP1 0.2603 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.