Drug : Tyrphostin Ag-1478

CTRP1 Name : tyrphostin AG-1478

Dataset : All
Synonyms :
Targets : EGFR
Pathways : inhibitor of EGFR

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
tyrphostin AG-1478 MCF-7 CTRP1 1.4787 189.2800
tyrphostin AG-1478 GAMG CTRP1 0.3697 47.3200
tyrphostin AG-1478 LN-229 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HEC-108 CTRP1 0.3697 47.3200
tyrphostin AG-1478 HEC-151 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HEC-59 CTRP1 0.3697 47.3200
tyrphostin AG-1478 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.3697 47.3200
tyrphostin AG-1478 JHUEM-2 CTRP1 1.4787 189.2800
tyrphostin AG-1478 KLE CTRP1 0.3697 47.3200
tyrphostin AG-1478 SNG-M CTRP1 0.3697 47.3200
tyrphostin AG-1478 AMO1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 BL-70 CTRP1 0.3697 47.3200
tyrphostin AG-1478 EJM CTRP1 1.4787 189.2800
tyrphostin AG-1478 GDM-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 KMS-11 CTRP1 1.4787 189.2800
tyrphostin AG-1478 LP-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 MOLM-16 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NOMO-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NU-DUL-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OCI-AML-3 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OCI-LY10 CTRP1 1.4787 189.2800
tyrphostin AG-1478 PL21 CTRP1 1.4787 189.2800
tyrphostin AG-1478 RPMI-8226 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SKM-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SU-DHL-4 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SU-DHL-5 CTRP1 1.4787 189.2800
tyrphostin AG-1478 THP-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 U-937 CTRP1 1.4787 189.2800
tyrphostin AG-1478 WSU-DLCL2 CTRP1 1.4787 189.2800
tyrphostin AG-1478 RCC10RGB CTRP1 1.4787 189.2800
tyrphostin AG-1478 CL-34 CTRP1 1.4787 189.2800
tyrphostin AG-1478 CL-40 CTRP1 1.4787 189.2800
tyrphostin AG-1478 COLO320 CTRP1 1.4787 189.2800
tyrphostin AG-1478 COLO678 CTRP1 1.4787 189.2800
tyrphostin AG-1478 CW-2 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCT116 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCT8 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HT115 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HT-29 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HT-55 CTRP1 1.4787 189.2800
tyrphostin AG-1478 KM12 CTRP1 1.4787 189.2800
tyrphostin AG-1478 LOVO CTRP1 1.4787 189.2800
tyrphostin AG-1478 LS123 CTRP1 1.4787 189.2800
tyrphostin AG-1478 LS180 CTRP1 1.4787 189.2800
tyrphostin AG-1478 MDST8 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H508 CTRP1 1.4787 189.2800
tyrphostin AG-1478 RCM-1[HUMANESC] CTRP1 1.4787 189.2800
tyrphostin AG-1478 RKO CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-1040 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-175 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-61 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-81 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-C4 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-C5 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SW480 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SW620 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SW948 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HEP-G2 CTRP1 1.4787 189.2800
tyrphostin AG-1478 JHH-6 CTRP1 0.3697 47.3200
tyrphostin AG-1478 SNU-398 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-449 CTRP1 0.3697 47.3200
tyrphostin AG-1478 CAL-12T CTRP1 1.4787 189.2800
tyrphostin AG-1478 COLO668 CTRP1 0.3697 47.3200
tyrphostin AG-1478 COLO699 CTRP1 1.4787 189.2800
tyrphostin AG-1478 COR-L23 CTRP1 1.4787 189.2800
tyrphostin AG-1478 COR-L51 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC1195 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC1359 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC15 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC1833 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC2108 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC2935 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC4006 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HCC827 CTRP1 1.4787 189.2800
tyrphostin AG-1478 LXF289 CTRP1 0.3697 47.3200
tyrphostin AG-1478 NCI-H1105 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H1435 CTRP1 0.3697 47.3200
tyrphostin AG-1478 NCI-H1694 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H1755 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H1781 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H1836 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H1876 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H1915 CTRP1 0.3697 47.3200
tyrphostin AG-1478 NCI-H1930 CTRP1 0.3697 47.3200
tyrphostin AG-1478 NCI-H1963 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2023 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2030 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2073 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2081 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2110 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2122 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2141 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2172 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H2286 CTRP1 0.3697 47.3200
tyrphostin AG-1478 NCI-H2342 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H3255 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H441 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H460 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H596 CTRP1 1.4787 189.2800
tyrphostin AG-1478 NCI-H841 CTRP1 1.4787 189.2800
tyrphostin AG-1478 RERF-LC-KJ CTRP1 0.3697 47.3200
tyrphostin AG-1478 SCLC-21H CTRP1 1.4787 189.2800
tyrphostin AG-1478 SK-LU-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SQ-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 T3M-10 CTRP1 1.4787 189.2800
tyrphostin AG-1478 A2780 CTRP1 1.4787 189.2800
tyrphostin AG-1478 CAOV-3 CTRP1 1.4787 189.2800
tyrphostin AG-1478 COV318 CTRP1 0.3697 47.3200
tyrphostin AG-1478 COV362 CTRP1 1.4787 189.2800
tyrphostin AG-1478 COV434 CTRP1 1.4787 189.2800
tyrphostin AG-1478 COV644 CTRP1 1.4787 189.2800
tyrphostin AG-1478 EFO-27 CTRP1 1.4787 189.2800
tyrphostin AG-1478 IGROV-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 JHOC-5 CTRP1 1.4787 189.2800
tyrphostin AG-1478 JHOM-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 JHOS-4 CTRP1 0.3697 47.3200
tyrphostin AG-1478 OAW42 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OV7 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OV-90 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OVCAR-4 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OVCAR-8 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OVK18 CTRP1 1.4787 189.2800
tyrphostin AG-1478 OVKATE CTRP1 1.4787 189.2800
tyrphostin AG-1478 OVMANA CTRP1 0.3697 47.3200
tyrphostin AG-1478 RKN CTRP1 1.4787 189.2800
tyrphostin AG-1478 RMG-I CTRP1 1.4787 189.2800
tyrphostin AG-1478 RMUG-S CTRP1 1.4787 189.2800
tyrphostin AG-1478 SNU-840 CTRP1 1.4787 189.2800
tyrphostin AG-1478 TYK-NU CTRP1 1.4787 189.2800
tyrphostin AG-1478 PATU8902 CTRP1 0.3697 47.3200
tyrphostin AG-1478 MIAPACA-3 CTRP1 0.3697 47.3200
tyrphostin AG-1478 A-375 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HS852.T CTRP1 0.3697 47.3200
tyrphostin AG-1478 SK-MEL-1 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SK-MEL-28 CTRP1 1.4787 189.2800
tyrphostin AG-1478 SK-MEL-5 CTRP1 1.4787 189.2800
tyrphostin AG-1478 HT-1080 CTRP1 1.4787 189.2800
tyrphostin AG-1478 AGS CTRP1 1.4787 189.2800
tyrphostin AG-1478 MKN74 CTRP1 0.3697 47.3200
tyrphostin AG-1478 SCC-9 CTRP1 1.4787 189.2800

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.