Drug : Endo-Iwr-1

CTRP1 Name : endo-IWR-1

Dataset : All
Synonyms :
Targets : AXIN1;AXIN2
Pathways : inhibitor of Axin2 degradation;inhibitor of Wnt signaling

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
endo-IWR-1 MCF-7 CTRP1 0.2604 33.3330
endo-IWR-1 GAMG CTRP1 0.2603 33.3330
endo-IWR-1 LN-229 CTRP1 0.2604 33.3330
endo-IWR-1 HEC-108 CTRP1 0.2603 33.3330
endo-IWR-1 HEC-151 CTRP1 0.1302 33.3330
endo-IWR-1 HEC-59 CTRP1 0.2603 33.3330
endo-IWR-1 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
endo-IWR-1 JHUEM-2 CTRP1 0.2604 33.3330
endo-IWR-1 KLE CTRP1 0.2603 33.3330
endo-IWR-1 SNG-M CTRP1 0.2603 33.3330
endo-IWR-1 AMO1 CTRP1 0.1302 33.3330
endo-IWR-1 BL-70 CTRP1 0.2603 33.3330
endo-IWR-1 EJM CTRP1 0.2604 33.3330
endo-IWR-1 GDM-1 CTRP1 0.2604 33.3330
endo-IWR-1 KMS-11 CTRP1 0.1302 33.3330
endo-IWR-1 LP-1 CTRP1 0.1302 33.3330
endo-IWR-1 MOLM-16 CTRP1 0.2604 33.3330
endo-IWR-1 NOMO-1 CTRP1 0.2604 33.3330
endo-IWR-1 NU-DUL-1 CTRP1 0.2604 33.3330
endo-IWR-1 OCI-AML-3 CTRP1 0.2604 33.3330
endo-IWR-1 OCI-LY10 CTRP1 0.1302 33.3330
endo-IWR-1 PL21 CTRP1 0.2604 33.3330
endo-IWR-1 RPMI-8226 CTRP1 0.2604 33.3330
endo-IWR-1 SKM-1 CTRP1 0.2604 33.3330
endo-IWR-1 SU-DHL-4 CTRP1 0.2604 33.3330
endo-IWR-1 SU-DHL-5 CTRP1 0.2604 33.3330
endo-IWR-1 THP-1 CTRP1 0.2604 33.3330
endo-IWR-1 U-937 CTRP1 0.2604 33.3330
endo-IWR-1 WSU-DLCL2 CTRP1 0.2604 33.3330
endo-IWR-1 CL-34 CTRP1 0.2604 33.3330
endo-IWR-1 CL-40 CTRP1 0.2604 33.3330
endo-IWR-1 COLO320 CTRP1 0.2604 33.3330
endo-IWR-1 COLO678 CTRP1 0.2604 33.3330
endo-IWR-1 CW-2 CTRP1 0.2604 33.3330
endo-IWR-1 HCT116 CTRP1 0.2604 33.3330
endo-IWR-1 HCT8 CTRP1 0.2604 33.3330
endo-IWR-1 HT115 CTRP1 0.2604 33.3330
endo-IWR-1 HT-29 CTRP1 0.2604 33.3330
endo-IWR-1 HT-55 CTRP1 0.2604 33.3330
endo-IWR-1 KM12 CTRP1 0.2604 33.3330
endo-IWR-1 LOVO CTRP1 0.2604 33.3330
endo-IWR-1 LS123 CTRP1 0.2604 33.3330
endo-IWR-1 LS180 CTRP1 0.1302 33.3330
endo-IWR-1 MDST8 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H508 CTRP1 0.2604 33.3330
endo-IWR-1 RCM-1[HUMANESC] CTRP1 0.2604 33.3330
endo-IWR-1 RKO CTRP1 0.2604 33.3330
endo-IWR-1 SNU-1040 CTRP1 0.2604 33.3330
endo-IWR-1 SNU-175 CTRP1 0.2604 33.3330
endo-IWR-1 SNU-61 CTRP1 0.2604 33.3330
endo-IWR-1 SNU-81 CTRP1 0.2604 33.3330
endo-IWR-1 SNU-C4 CTRP1 0.2604 33.3330
endo-IWR-1 SNU-C5 CTRP1 0.2604 33.3330
endo-IWR-1 SW480 CTRP1 0.2604 33.3330
endo-IWR-1 SW620 CTRP1 0.2604 33.3330
endo-IWR-1 SW948 CTRP1 0.2604 33.3330
endo-IWR-1 HEP-G2 CTRP1 0.2604 33.3330
endo-IWR-1 JHH-6 CTRP1 0.2603 33.3330
endo-IWR-1 SNU-398 CTRP1 0.1302 33.3330
endo-IWR-1 SNU-449 CTRP1 0.2603 33.3330
endo-IWR-1 CAL-12T CTRP1 0.2604 33.3330
endo-IWR-1 COLO668 CTRP1 0.2603 33.3330
endo-IWR-1 COLO699 CTRP1 0.2604 33.3330
endo-IWR-1 COR-L23 CTRP1 0.2604 33.3330
endo-IWR-1 COR-L51 CTRP1 0.1302 33.3330
endo-IWR-1 HCC1195 CTRP1 0.2604 33.3330
endo-IWR-1 HCC1359 CTRP1 0.2604 33.3330
endo-IWR-1 HCC15 CTRP1 0.2604 33.3330
endo-IWR-1 HCC1833 CTRP1 0.2604 33.3330
endo-IWR-1 HCC2108 CTRP1 0.2604 33.3330
endo-IWR-1 HCC2935 CTRP1 0.2604 33.3330
endo-IWR-1 HCC4006 CTRP1 0.2604 33.3330
endo-IWR-1 HCC827 CTRP1 0.2604 33.3330
endo-IWR-1 LXF289 CTRP1 0.2603 33.3330
endo-IWR-1 NCI-H1105 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H1435 CTRP1 0.2603 33.3330
endo-IWR-1 NCI-H1694 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H1755 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H1781 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H1836 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H1876 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H1915 CTRP1 0.2603 33.3330
endo-IWR-1 NCI-H1930 CTRP1 0.2603 33.3330
endo-IWR-1 NCI-H1963 CTRP1 0.1302 33.3330
endo-IWR-1 NCI-H2023 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H2030 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H2073 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H2081 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H2110 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H2122 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H2141 CTRP1 0.1302 33.3330
endo-IWR-1 NCI-H2172 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H2286 CTRP1 0.2603 33.3330
endo-IWR-1 NCI-H2342 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H3255 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H441 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H460 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H596 CTRP1 0.2604 33.3330
endo-IWR-1 NCI-H841 CTRP1 0.2604 33.3330
endo-IWR-1 RERF-LC-KJ CTRP1 0.2603 33.3330
endo-IWR-1 SCLC-21H CTRP1 0.1302 33.3330
endo-IWR-1 SK-LU-1 CTRP1 0.2604 33.3330
endo-IWR-1 SQ-1 CTRP1 0.2604 33.3330
endo-IWR-1 T3M-10 CTRP1 0.2604 33.3330
endo-IWR-1 A2780 CTRP1 0.1302 33.3330
endo-IWR-1 CAOV-3 CTRP1 0.2604 33.3330
endo-IWR-1 COV318 CTRP1 0.2603 33.3330
endo-IWR-1 COV362 CTRP1 0.2604 33.3330
endo-IWR-1 COV434 CTRP1 0.2604 33.3330
endo-IWR-1 COV644 CTRP1 0.2604 33.3330
endo-IWR-1 EFO-27 CTRP1 0.2604 33.3330
endo-IWR-1 IGROV-1 CTRP1 0.1302 33.3330
endo-IWR-1 JHOC-5 CTRP1 0.2604 33.3330
endo-IWR-1 JHOM-1 CTRP1 0.2604 33.3330
endo-IWR-1 JHOS-4 CTRP1 0.2603 33.3330
endo-IWR-1 OAW42 CTRP1 0.2604 33.3330
endo-IWR-1 OV7 CTRP1 0.2604 33.3330
endo-IWR-1 OV-90 CTRP1 0.2604 33.3330
endo-IWR-1 OVCAR-4 CTRP1 0.1302 33.3330
endo-IWR-1 OVCAR-8 CTRP1 0.1302 33.3330
endo-IWR-1 OVK18 CTRP1 0.2604 33.3330
endo-IWR-1 OVKATE CTRP1 0.1302 33.3330
endo-IWR-1 OVMANA CTRP1 0.2603 33.3330
endo-IWR-1 RKN CTRP1 0.1302 33.3330
endo-IWR-1 RMG-I CTRP1 0.2604 33.3330
endo-IWR-1 RMUG-S CTRP1 0.2604 33.3330
endo-IWR-1 SNU-840 CTRP1 0.2604 33.3330
endo-IWR-1 TYK-NU CTRP1 0.2604 33.3330
endo-IWR-1 PATU8902 CTRP1 0.2603 33.3330
endo-IWR-1 MIAPACA-3 CTRP1 0.2603 33.3330
endo-IWR-1 A-375 CTRP1 0.2604 33.3330
endo-IWR-1 HS852.T CTRP1 0.2603 33.3330
endo-IWR-1 SK-MEL-1 CTRP1 0.2604 33.3330
endo-IWR-1 SK-MEL-28 CTRP1 0.2604 33.3330
endo-IWR-1 SK-MEL-5 CTRP1 0.2604 33.3330
endo-IWR-1 HT-1080 CTRP1 0.2604 33.3330
endo-IWR-1 AGS CTRP1 0.1302 33.3330
endo-IWR-1 MKN74 CTRP1 0.2603 33.3330
endo-IWR-1 SCC-9 CTRP1 0.1302 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.