Drug : Zm336372

CTRP1 Name : ZM336372

Dataset : All
Synonyms :
Targets : RAF1
Pathways : inhibitor of c-RAF;activator of the RAF1 signaling pathway

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
ZM336372 MCF-7 CTRP1 2.6747 342.3700
ZM336372 GAMG CTRP1 0.3343 42.7960
ZM336372 LN-229 CTRP1 2.6747 342.3700
ZM336372 HEC-108 CTRP1 0.3343 42.7960
ZM336372 HEC-151 CTRP1 2.6747 342.3700
ZM336372 HEC-59 CTRP1 0.3343 42.7960
ZM336372 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.3343 42.7960
ZM336372 JHUEM-2 CTRP1 2.6747 342.3700
ZM336372 KLE CTRP1 0.3343 42.7960
ZM336372 SNG-M CTRP1 0.3343 42.7960
ZM336372 AMO1 CTRP1 2.6747 342.3700
ZM336372 BL-70 CTRP1 0.3343 42.7960
ZM336372 EJM CTRP1 2.6747 342.3700
ZM336372 GDM-1 CTRP1 2.6747 342.3700
ZM336372 KMS-11 CTRP1 2.6747 342.3700
ZM336372 LP-1 CTRP1 2.6747 342.3700
ZM336372 MOLM-16 CTRP1 2.6747 342.3700
ZM336372 NOMO-1 CTRP1 2.6747 342.3700
ZM336372 NU-DUL-1 CTRP1 2.6747 342.3700
ZM336372 OCI-AML-3 CTRP1 2.6747 342.3700
ZM336372 OCI-LY10 CTRP1 2.6747 342.3700
ZM336372 PL21 CTRP1 2.6747 342.3700
ZM336372 RPMI-8226 CTRP1 2.6747 342.3700
ZM336372 SKM-1 CTRP1 2.6747 342.3700
ZM336372 SU-DHL-4 CTRP1 2.6747 342.3700
ZM336372 SU-DHL-5 CTRP1 2.6747 342.3700
ZM336372 THP-1 CTRP1 2.6747 342.3700
ZM336372 U-937 CTRP1 2.6747 342.3700
ZM336372 WSU-DLCL2 CTRP1 2.6747 342.3700
ZM336372 RCC10RGB CTRP1 2.6747 342.3700
ZM336372 CL-34 CTRP1 2.6747 342.3700
ZM336372 CL-40 CTRP1 2.6747 342.3700
ZM336372 COLO320 CTRP1 2.6747 342.3700
ZM336372 COLO678 CTRP1 2.6747 342.3700
ZM336372 CW-2 CTRP1 2.6747 342.3700
ZM336372 HCT116 CTRP1 2.6747 342.3700
ZM336372 HCT8 CTRP1 2.6747 342.3700
ZM336372 HT115 CTRP1 2.6747 342.3700
ZM336372 HT-29 CTRP1 2.6747 342.3700
ZM336372 HT-55 CTRP1 2.6747 342.3700
ZM336372 KM12 CTRP1 2.6747 342.3700
ZM336372 LOVO CTRP1 2.6747 342.3700
ZM336372 LS123 CTRP1 2.6747 342.3700
ZM336372 LS180 CTRP1 2.6747 342.3700
ZM336372 MDST8 CTRP1 2.6747 342.3700
ZM336372 NCI-H508 CTRP1 2.6747 342.3700
ZM336372 RCM-1[HUMANESC] CTRP1 2.6747 342.3700
ZM336372 RKO CTRP1 2.6747 342.3700
ZM336372 SNU-1040 CTRP1 2.6747 342.3700
ZM336372 SNU-175 CTRP1 2.6747 342.3700
ZM336372 SNU-61 CTRP1 2.6747 342.3700
ZM336372 SNU-81 CTRP1 2.6747 342.3700
ZM336372 SNU-C4 CTRP1 2.6747 342.3700
ZM336372 SNU-C5 CTRP1 2.6747 342.3700
ZM336372 SW480 CTRP1 2.6747 342.3700
ZM336372 SW620 CTRP1 2.6747 342.3700
ZM336372 SW948 CTRP1 2.6747 342.3700
ZM336372 HEP-G2 CTRP1 2.6747 342.3700
ZM336372 JHH-6 CTRP1 0.3343 42.7960
ZM336372 SNU-398 CTRP1 2.6747 342.3700
ZM336372 SNU-449 CTRP1 0.3343 42.7960
ZM336372 CAL-12T CTRP1 2.6747 342.3700
ZM336372 COLO668 CTRP1 0.3343 42.7960
ZM336372 COLO699 CTRP1 2.6747 342.3700
ZM336372 COR-L23 CTRP1 2.6747 342.3700
ZM336372 COR-L51 CTRP1 2.6747 342.3700
ZM336372 HCC1195 CTRP1 2.6747 342.3700
ZM336372 HCC1359 CTRP1 2.6747 342.3700
ZM336372 HCC15 CTRP1 2.6747 342.3700
ZM336372 HCC1833 CTRP1 2.6747 342.3700
ZM336372 HCC2108 CTRP1 2.6747 342.3700
ZM336372 HCC2935 CTRP1 2.6747 342.3700
ZM336372 HCC4006 CTRP1 2.6747 342.3700
ZM336372 HCC827 CTRP1 2.6747 342.3700
ZM336372 LXF289 CTRP1 0.3343 42.7960
ZM336372 NCI-H1105 CTRP1 2.6747 342.3700
ZM336372 NCI-H1435 CTRP1 0.3343 42.7960
ZM336372 NCI-H1694 CTRP1 2.6747 342.3700
ZM336372 NCI-H1755 CTRP1 2.6747 342.3700
ZM336372 NCI-H1781 CTRP1 2.6747 342.3700
ZM336372 NCI-H1836 CTRP1 2.6747 342.3700
ZM336372 NCI-H1876 CTRP1 2.6747 342.3700
ZM336372 NCI-H1915 CTRP1 0.3343 42.7960
ZM336372 NCI-H1930 CTRP1 0.3343 42.7960
ZM336372 NCI-H1963 CTRP1 2.6747 342.3700
ZM336372 NCI-H2023 CTRP1 2.6747 342.3700
ZM336372 NCI-H2030 CTRP1 2.6747 342.3700
ZM336372 NCI-H2073 CTRP1 2.6747 342.3700
ZM336372 NCI-H2081 CTRP1 2.6747 342.3700
ZM336372 NCI-H2110 CTRP1 2.6747 342.3700
ZM336372 NCI-H2122 CTRP1 2.6747 342.3700
ZM336372 NCI-H2141 CTRP1 2.6747 342.3700
ZM336372 NCI-H2172 CTRP1 2.6747 342.3700
ZM336372 NCI-H2286 CTRP1 0.3343 42.7960
ZM336372 NCI-H2342 CTRP1 2.6747 342.3700
ZM336372 NCI-H3255 CTRP1 2.6747 342.3700
ZM336372 NCI-H441 CTRP1 2.6747 342.3700
ZM336372 NCI-H460 CTRP1 2.6747 342.3700
ZM336372 NCI-H596 CTRP1 2.6747 342.3700
ZM336372 NCI-H841 CTRP1 2.6747 342.3700
ZM336372 RERF-LC-KJ CTRP1 0.3343 42.7960
ZM336372 SCLC-21H CTRP1 2.6747 342.3700
ZM336372 SK-LU-1 CTRP1 2.6747 342.3700
ZM336372 SQ-1 CTRP1 2.6747 342.3700
ZM336372 T3M-10 CTRP1 2.6747 342.3700
ZM336372 A2780 CTRP1 2.6747 342.3700
ZM336372 CAOV-3 CTRP1 2.6747 342.3700
ZM336372 COV318 CTRP1 0.3343 42.7960
ZM336372 COV362 CTRP1 2.6747 342.3700
ZM336372 COV434 CTRP1 2.6747 342.3700
ZM336372 COV644 CTRP1 2.6747 342.3700
ZM336372 EFO-27 CTRP1 2.6747 342.3700
ZM336372 IGROV-1 CTRP1 2.6747 342.3700
ZM336372 JHOC-5 CTRP1 2.6747 342.3700
ZM336372 JHOM-1 CTRP1 2.6747 342.3700
ZM336372 JHOS-4 CTRP1 0.3343 42.7960
ZM336372 OAW42 CTRP1 2.6747 342.3700
ZM336372 OV7 CTRP1 2.6747 342.3700
ZM336372 OV-90 CTRP1 2.6747 342.3700
ZM336372 OVCAR-4 CTRP1 2.6747 342.3700
ZM336372 OVCAR-8 CTRP1 2.6747 342.3700
ZM336372 OVK18 CTRP1 2.6747 342.3700
ZM336372 OVKATE CTRP1 2.6747 342.3700
ZM336372 OVMANA CTRP1 0.3343 42.7960
ZM336372 RKN CTRP1 2.6747 342.3700
ZM336372 RMG-I CTRP1 2.6747 342.3700
ZM336372 RMUG-S CTRP1 2.6747 342.3700
ZM336372 SNU-840 CTRP1 2.6747 342.3700
ZM336372 TYK-NU CTRP1 2.6747 342.3700
ZM336372 PATU8902 CTRP1 0.3343 42.7960
ZM336372 MIAPACA-3 CTRP1 0.3343 42.7960
ZM336372 A-375 CTRP1 2.6747 342.3700
ZM336372 HS852.T CTRP1 0.3343 42.7960
ZM336372 SK-MEL-1 CTRP1 2.6747 342.3700
ZM336372 SK-MEL-28 CTRP1 2.6747 342.3700
ZM336372 SK-MEL-5 CTRP1 2.6747 342.3700
ZM336372 HT-1080 CTRP1 2.6747 342.3700
ZM336372 AGS CTRP1 2.6747 342.3700
ZM336372 MKN74 CTRP1 0.3343 42.7960
ZM336372 SCC-9 CTRP1 2.6747 342.3700

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.