Drug : Pnu-74654

CTRP1 Name : PNU-74654

Dataset : All
Synonyms :
Targets : CTNNB1
Pathways : inhibitor of the interaction between CTNNB1 and TCF4

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
PNU-74654 MCF-7 CTRP1 2.0833 266.6700
PNU-74654 GAMG CTRP1 0.2603 33.3330
PNU-74654 LN-229 CTRP1 2.0833 266.6700
PNU-74654 HEC-108 CTRP1 0.2603 33.3330
PNU-74654 HEC-151 CTRP1 2.0833 266.6700
PNU-74654 HEC-59 CTRP1 0.2603 33.3330
PNU-74654 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
PNU-74654 JHUEM-2 CTRP1 2.0833 266.6700
PNU-74654 KLE CTRP1 0.2603 33.3330
PNU-74654 SNG-M CTRP1 0.2603 33.3330
PNU-74654 AMO1 CTRP1 2.0833 266.6700
PNU-74654 BL-70 CTRP1 0.2603 33.3330
PNU-74654 EJM CTRP1 2.0833 266.6700
PNU-74654 GDM-1 CTRP1 2.0833 266.6700
PNU-74654 KMS-11 CTRP1 2.0833 266.6700
PNU-74654 LP-1 CTRP1 2.0833 266.6700
PNU-74654 MOLM-16 CTRP1 2.0833 266.6700
PNU-74654 NOMO-1 CTRP1 2.0833 266.6700
PNU-74654 NU-DUL-1 CTRP1 2.0833 266.6700
PNU-74654 OCI-AML-3 CTRP1 2.0833 266.6700
PNU-74654 OCI-LY10 CTRP1 2.0833 266.6700
PNU-74654 PL21 CTRP1 2.0833 266.6700
PNU-74654 RPMI-8226 CTRP1 2.0833 266.6700
PNU-74654 SKM-1 CTRP1 2.0833 266.6700
PNU-74654 SU-DHL-4 CTRP1 2.0833 266.6700
PNU-74654 SU-DHL-5 CTRP1 2.0833 266.6700
PNU-74654 THP-1 CTRP1 2.0833 266.6700
PNU-74654 U-937 CTRP1 2.0833 266.6700
PNU-74654 WSU-DLCL2 CTRP1 2.0833 266.6700
PNU-74654 RCC10RGB CTRP1 2.0833 266.6700
PNU-74654 CL-34 CTRP1 2.0833 266.6700
PNU-74654 CL-40 CTRP1 2.0833 266.6700
PNU-74654 COLO320 CTRP1 2.0833 266.6700
PNU-74654 COLO678 CTRP1 2.0833 266.6700
PNU-74654 CW-2 CTRP1 2.0833 266.6700
PNU-74654 HCT116 CTRP1 2.0833 266.6700
PNU-74654 HCT8 CTRP1 2.0833 266.6700
PNU-74654 HT115 CTRP1 2.0833 266.6700
PNU-74654 HT-29 CTRP1 2.0833 266.6700
PNU-74654 HT-55 CTRP1 2.0833 266.6700
PNU-74654 KM12 CTRP1 2.0833 266.6700
PNU-74654 LOVO CTRP1 2.0833 266.6700
PNU-74654 LS123 CTRP1 2.0833 266.6700
PNU-74654 LS180 CTRP1 2.0833 266.6700
PNU-74654 MDST8 CTRP1 2.0833 266.6700
PNU-74654 NCI-H508 CTRP1 2.0833 266.6700
PNU-74654 RCM-1[HUMANESC] CTRP1 2.0833 266.6700
PNU-74654 RKO CTRP1 2.0833 266.6700
PNU-74654 SNU-1040 CTRP1 2.0833 266.6700
PNU-74654 SNU-175 CTRP1 2.0833 266.6700
PNU-74654 SNU-61 CTRP1 2.0833 266.6700
PNU-74654 SNU-81 CTRP1 2.0833 266.6700
PNU-74654 SNU-C4 CTRP1 2.0833 266.6700
PNU-74654 SNU-C5 CTRP1 2.0833 266.6700
PNU-74654 SW480 CTRP1 2.0833 266.6700
PNU-74654 SW620 CTRP1 2.0833 266.6700
PNU-74654 SW948 CTRP1 2.0833 266.6700
PNU-74654 HEP-G2 CTRP1 2.0833 266.6700
PNU-74654 JHH-6 CTRP1 0.2603 33.3330
PNU-74654 SNU-398 CTRP1 2.0833 266.6700
PNU-74654 SNU-449 CTRP1 0.2603 33.3330
PNU-74654 CAL-12T CTRP1 2.0833 266.6700
PNU-74654 COLO668 CTRP1 0.2603 33.3330
PNU-74654 COLO699 CTRP1 2.0833 266.6700
PNU-74654 COR-L23 CTRP1 2.0833 266.6700
PNU-74654 COR-L51 CTRP1 2.0833 266.6700
PNU-74654 HCC1195 CTRP1 2.0833 266.6700
PNU-74654 HCC1359 CTRP1 2.0833 266.6700
PNU-74654 HCC15 CTRP1 2.0833 266.6700
PNU-74654 HCC1833 CTRP1 2.0833 266.6700
PNU-74654 HCC2108 CTRP1 2.0833 266.6700
PNU-74654 HCC2935 CTRP1 2.0833 266.6700
PNU-74654 HCC4006 CTRP1 2.0833 266.6700
PNU-74654 HCC827 CTRP1 2.0833 266.6700
PNU-74654 LXF289 CTRP1 0.2603 33.3330
PNU-74654 NCI-H1105 CTRP1 2.0833 266.6700
PNU-74654 NCI-H1435 CTRP1 0.2603 33.3330
PNU-74654 NCI-H1694 CTRP1 2.0833 266.6700
PNU-74654 NCI-H1755 CTRP1 2.0833 266.6700
PNU-74654 NCI-H1781 CTRP1 2.0833 266.6700
PNU-74654 NCI-H1836 CTRP1 2.0833 266.6700
PNU-74654 NCI-H1876 CTRP1 2.0833 266.6700
PNU-74654 NCI-H1915 CTRP1 0.2603 33.3330
PNU-74654 NCI-H1930 CTRP1 0.2603 33.3330
PNU-74654 NCI-H1963 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2023 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2030 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2073 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2081 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2110 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2122 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2141 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2172 CTRP1 2.0833 266.6700
PNU-74654 NCI-H2286 CTRP1 0.2603 33.3330
PNU-74654 NCI-H2342 CTRP1 2.0833 266.6700
PNU-74654 NCI-H3255 CTRP1 2.0833 266.6700
PNU-74654 NCI-H441 CTRP1 2.0833 266.6700
PNU-74654 NCI-H460 CTRP1 2.0833 266.6700
PNU-74654 NCI-H596 CTRP1 2.0833 266.6700
PNU-74654 NCI-H841 CTRP1 2.0833 266.6700
PNU-74654 RERF-LC-KJ CTRP1 0.2603 33.3330
PNU-74654 SCLC-21H CTRP1 2.0833 266.6700
PNU-74654 SK-LU-1 CTRP1 2.0833 266.6700
PNU-74654 SQ-1 CTRP1 2.0833 266.6700
PNU-74654 T3M-10 CTRP1 2.0833 266.6700
PNU-74654 A2780 CTRP1 2.0833 266.6700
PNU-74654 CAOV-3 CTRP1 2.0833 266.6700
PNU-74654 COV318 CTRP1 0.2603 33.3330
PNU-74654 COV362 CTRP1 2.0833 266.6700
PNU-74654 COV434 CTRP1 2.0833 266.6700
PNU-74654 COV644 CTRP1 2.0833 266.6700
PNU-74654 EFO-27 CTRP1 2.0833 266.6700
PNU-74654 IGROV-1 CTRP1 2.0833 266.6700
PNU-74654 JHOC-5 CTRP1 2.0833 266.6700
PNU-74654 JHOM-1 CTRP1 2.0833 266.6700
PNU-74654 JHOS-4 CTRP1 0.2603 33.3330
PNU-74654 OAW42 CTRP1 2.0833 266.6700
PNU-74654 OV7 CTRP1 2.0833 266.6700
PNU-74654 OV-90 CTRP1 2.0833 266.6700
PNU-74654 OVCAR-4 CTRP1 2.0833 266.6700
PNU-74654 OVCAR-8 CTRP1 2.0833 266.6700
PNU-74654 OVK18 CTRP1 2.0833 266.6700
PNU-74654 OVKATE CTRP1 2.0833 266.6700
PNU-74654 OVMANA CTRP1 0.2603 33.3330
PNU-74654 RKN CTRP1 2.0833 266.6700
PNU-74654 RMG-I CTRP1 2.0833 266.6700
PNU-74654 RMUG-S CTRP1 2.0833 266.6700
PNU-74654 SNU-840 CTRP1 2.0833 266.6700
PNU-74654 TYK-NU CTRP1 2.0833 266.6700
PNU-74654 PATU8902 CTRP1 0.2603 33.3330
PNU-74654 MIAPACA-3 CTRP1 0.2603 33.3330
PNU-74654 A-375 CTRP1 2.0833 266.6700
PNU-74654 HS852.T CTRP1 0.2603 33.3330
PNU-74654 SK-MEL-1 CTRP1 2.0833 266.6700
PNU-74654 SK-MEL-28 CTRP1 2.0833 266.6700
PNU-74654 SK-MEL-5 CTRP1 2.0833 266.6700
PNU-74654 HT-1080 CTRP1 2.0833 266.6700
PNU-74654 AGS CTRP1 2.0833 266.6700
PNU-74654 MKN74 CTRP1 0.2603 33.3330
PNU-74654 SCC-9 CTRP1 2.0833 266.6700

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.