Drug : Bms-299897

CTRP1 Name : BMS-299897

Dataset : All
Synonyms :
Targets : NCSTN;PSEN1;PSENEN;APH1A
Pathways : inhibitor of gamma-secretase

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

:


Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
BMS-299897 U2OS CTRP1 0.2604 33.3330
BMS-299897 MCF-7 CTRP1 0.2604 33.3330
BMS-299897 GAMG CTRP1 0.2603 33.3330
BMS-299897 LN-229 CTRP1 0.2604 33.3330
BMS-299897 HEC-108 CTRP1 0.2603 33.3330
BMS-299897 HEC-151 CTRP1 0.2604 33.3330
BMS-299897 HEC-59 CTRP1 0.2603 33.3330
BMS-299897 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
BMS-299897 JHUEM-2 CTRP1 0.2604 33.3330
BMS-299897 KLE CTRP1 0.2603 33.3330
BMS-299897 SNG-M CTRP1 0.2603 33.3330
BMS-299897 AMO1 CTRP1 0.2604 33.3330
BMS-299897 BL-70 CTRP1 0.2603 33.3330
BMS-299897 EJM CTRP1 0.2604 33.3330
BMS-299897 GDM-1 CTRP1 0.2604 33.3330
BMS-299897 KMS-11 CTRP1 0.2604 33.3330
BMS-299897 LP-1 CTRP1 0.2604 33.3330
BMS-299897 MOLM-16 CTRP1 0.2604 33.3330
BMS-299897 NOMO-1 CTRP1 0.2604 33.3330
BMS-299897 NU-DUL-1 CTRP1 0.2604 33.3330
BMS-299897 OCI-AML-3 CTRP1 0.2604 33.3330
BMS-299897 OCI-LY10 CTRP1 0.2604 33.3330
BMS-299897 PL21 CTRP1 0.2604 33.3330
BMS-299897 RPMI-8226 CTRP1 0.2604 33.3330
BMS-299897 SKM-1 CTRP1 0.2604 33.3330
BMS-299897 SU-DHL-4 CTRP1 0.2604 33.3330
BMS-299897 SU-DHL-5 CTRP1 0.2604 33.3330
BMS-299897 THP-1 CTRP1 0.2604 33.3330
BMS-299897 U-937 CTRP1 0.2604 33.3330
BMS-299897 WSU-DLCL2 CTRP1 0.2604 33.3330
BMS-299897 RCC10RGB CTRP1 0.2604 33.3330
BMS-299897 CL-34 CTRP1 0.2604 33.3330
BMS-299897 CL-40 CTRP1 0.2604 33.3330
BMS-299897 COLO320 CTRP1 0.2604 33.3330
BMS-299897 COLO678 CTRP1 0.2604 33.3330
BMS-299897 CW-2 CTRP1 0.2604 33.3330
BMS-299897 HCT116 CTRP1 0.2604 33.3330
BMS-299897 HCT8 CTRP1 0.2604 33.3330
BMS-299897 HT115 CTRP1 0.2604 33.3330
BMS-299897 HT-29 CTRP1 0.2604 33.3330
BMS-299897 HT-55 CTRP1 0.2604 33.3330
BMS-299897 KM12 CTRP1 0.2604 33.3330
BMS-299897 LOVO CTRP1 0.2604 33.3330
BMS-299897 LS123 CTRP1 0.2604 33.3330
BMS-299897 LS180 CTRP1 0.2604 33.3330
BMS-299897 MDST8 CTRP1 0.2604 33.3330
BMS-299897 NCI-H508 CTRP1 0.2604 33.3330
BMS-299897 RCM-1[HUMANESC] CTRP1 0.2604 33.3330
BMS-299897 RKO CTRP1 0.2604 33.3330
BMS-299897 SNU-1040 CTRP1 0.2604 33.3330
BMS-299897 SNU-175 CTRP1 0.2604 33.3330
BMS-299897 SNU-61 CTRP1 0.2604 33.3330
BMS-299897 SNU-81 CTRP1 0.2604 33.3330
BMS-299897 SNU-C4 CTRP1 0.2604 33.3330
BMS-299897 SNU-C5 CTRP1 0.2604 33.3330
BMS-299897 SW480 CTRP1 0.2604 33.3330
BMS-299897 SW620 CTRP1 0.2604 33.3330
BMS-299897 SW948 CTRP1 0.2604 33.3330
BMS-299897 HEP-G2 CTRP1 0.2604 33.3330
BMS-299897 JHH-6 CTRP1 0.2603 33.3330
BMS-299897 SNU-398 CTRP1 0.2604 33.3330
BMS-299897 SNU-449 CTRP1 0.2603 33.3330
BMS-299897 CAL-12T CTRP1 0.2604 33.3330
BMS-299897 COLO668 CTRP1 0.2603 33.3330
BMS-299897 COLO699 CTRP1 0.2604 33.3330
BMS-299897 COR-L23 CTRP1 0.2604 33.3330
BMS-299897 COR-L51 CTRP1 0.2604 33.3330
BMS-299897 HCC1195 CTRP1 0.2604 33.3330
BMS-299897 HCC1359 CTRP1 0.2604 33.3330
BMS-299897 HCC15 CTRP1 0.2604 33.3330
BMS-299897 HCC1833 CTRP1 0.2604 33.3330
BMS-299897 HCC2108 CTRP1 0.2604 33.3330
BMS-299897 HCC2935 CTRP1 0.2604 33.3330
BMS-299897 HCC4006 CTRP1 0.2604 33.3330
BMS-299897 HCC827 CTRP1 0.2604 33.3330
BMS-299897 LXF289 CTRP1 0.2603 33.3330
BMS-299897 NCI-H1105 CTRP1 0.2604 33.3330
BMS-299897 NCI-H1435 CTRP1 0.2603 33.3330
BMS-299897 NCI-H1694 CTRP1 0.2604 33.3330
BMS-299897 NCI-H1755 CTRP1 0.2604 33.3330
BMS-299897 NCI-H1781 CTRP1 0.2604 33.3330
BMS-299897 NCI-H1836 CTRP1 0.2604 33.3330
BMS-299897 NCI-H1876 CTRP1 0.2604 33.3330
BMS-299897 NCI-H1915 CTRP1 0.2603 33.3330
BMS-299897 NCI-H1930 CTRP1 0.2603 33.3330
BMS-299897 NCI-H1963 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2023 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2030 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2073 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2081 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2110 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2122 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2141 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2172 CTRP1 0.2604 33.3330
BMS-299897 NCI-H2286 CTRP1 0.2603 33.3330
BMS-299897 NCI-H2342 CTRP1 0.2604 33.3330
BMS-299897 NCI-H3255 CTRP1 0.2604 33.3330
BMS-299897 NCI-H441 CTRP1 0.2604 33.3330
BMS-299897 NCI-H460 CTRP1 0.2604 33.3330
BMS-299897 NCI-H596 CTRP1 0.2604 33.3330
BMS-299897 NCI-H841 CTRP1 0.2604 33.3330
BMS-299897 RERF-LC-KJ CTRP1 0.2603 33.3330
BMS-299897 SCLC-21H CTRP1 0.2604 33.3330
BMS-299897 SK-LU-1 CTRP1 0.2604 33.3330
BMS-299897 SQ-1 CTRP1 0.2604 33.3330
BMS-299897 T3M-10 CTRP1 0.2604 33.3330
BMS-299897 A2780 CTRP1 0.2604 33.3330
BMS-299897 CAOV-3 CTRP1 0.2604 33.3330
BMS-299897 COV318 CTRP1 0.2603 33.3330
BMS-299897 COV362 CTRP1 0.2604 33.3330
BMS-299897 COV434 CTRP1 0.2604 33.3330
BMS-299897 COV644 CTRP1 0.2604 33.3330
BMS-299897 EFO-27 CTRP1 0.2604 33.3330
BMS-299897 IGROV-1 CTRP1 0.2604 33.3330
BMS-299897 JHOC-5 CTRP1 0.2604 33.3330
BMS-299897 JHOM-1 CTRP1 0.2604 33.3330
BMS-299897 JHOS-4 CTRP1 0.2603 33.3330
BMS-299897 OAW42 CTRP1 0.2604 33.3330
BMS-299897 OV7 CTRP1 0.2604 33.3330
BMS-299897 OV-90 CTRP1 0.2604 33.3330
BMS-299897 OVCAR-4 CTRP1 0.2604 33.3330
BMS-299897 OVCAR-8 CTRP1 0.2604 33.3330
BMS-299897 OVK18 CTRP1 0.2604 33.3330
BMS-299897 OVKATE CTRP1 0.2604 33.3330
BMS-299897 OVMANA CTRP1 0.2603 33.3330
BMS-299897 RKN CTRP1 0.2604 33.3330
BMS-299897 RMG-I CTRP1 0.2604 33.3330
BMS-299897 RMUG-S CTRP1 0.2604 33.3330
BMS-299897 SNU-840 CTRP1 0.2604 33.3330
BMS-299897 TYK-NU CTRP1 0.2604 33.3330
BMS-299897 PATU8902 CTRP1 0.2603 33.3330
BMS-299897 MIAPACA-3 CTRP1 0.2603 33.3330
BMS-299897 A-375 CTRP1 0.2604 33.3330
BMS-299897 HS852.T CTRP1 0.2603 33.3330
BMS-299897 SK-MEL-1 CTRP1 0.2604 33.3330
BMS-299897 SK-MEL-28 CTRP1 0.2604 33.3330
BMS-299897 SK-MEL-5 CTRP1 0.2604 33.3330
BMS-299897 HT-1080 CTRP1 0.2604 33.3330
BMS-299897 AGS CTRP1 0.2604 33.3330
BMS-299897 MKN74 CTRP1 0.2603 33.3330
BMS-299897 SCC-9 CTRP1 0.2604 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.