Drug : Irosustat

CTRP1 Name : irosustat

Dataset : All
Synonyms :
Targets : STS
Pathways : inhibitor of steroid sulfatase

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
irosustat GAMG CTRP1 0.2603 33.3330
irosustat HEC-108 CTRP1 0.2603 33.3330
irosustat HEC-59 CTRP1 0.2603 33.3330
irosustat ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
irosustat KLE CTRP1 0.2603 33.3330
irosustat SNG-M CTRP1 0.2603 33.3330
irosustat BL-70 CTRP1 0.2603 33.3330
irosustat JHH-6 CTRP1 0.2603 33.3330
irosustat SNU-449 CTRP1 0.2603 33.3330
irosustat COLO668 CTRP1 0.2603 33.3330
irosustat LXF289 CTRP1 0.2603 33.3330
irosustat NCI-H1435 CTRP1 0.2603 33.3330
irosustat NCI-H1915 CTRP1 0.2603 33.3330
irosustat NCI-H1930 CTRP1 0.2603 33.3330
irosustat NCI-H2286 CTRP1 0.2603 33.3330
irosustat RERF-LC-KJ CTRP1 0.2603 33.3330
irosustat COV318 CTRP1 0.2603 33.3330
irosustat JHOS-4 CTRP1 0.2603 33.3330
irosustat OVMANA CTRP1 0.2603 33.3330
irosustat PATU8902 CTRP1 0.2603 33.3330
irosustat MIAPACA-3 CTRP1 0.2603 33.3330
irosustat HS852.T CTRP1 0.2603 33.3330
irosustat MKN74 CTRP1 0.2603 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.
OTOFOCA2ASXL3FBN1NAA80FSIP2AHNAK2HLA-C−2−1.5−1−0.500.51
GeneRanksum's Effect Size

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.