Drug : Carbamazepine

CTRP1 Name : carbamazepine

Dataset : All
Synonyms :
Targets : SCN3A;SCN9A;SCN10A
Pathways : anticonvulsant;inhibitor of voltage-gated sodium channels

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
carbamazepine LN-229 CTRP1 2.5000 320.0000
carbamazepine JHUEM-2 CTRP1 2.5000 320.0000
carbamazepine GDM-1 CTRP1 2.5000 320.0000
carbamazepine MOLM-16 CTRP1 2.5000 320.0000
carbamazepine NOMO-1 CTRP1 2.5000 320.0000
carbamazepine NU-DUL-1 CTRP1 2.5000 320.0000
carbamazepine OCI-AML-3 CTRP1 2.5000 320.0000
carbamazepine PL21 CTRP1 2.5000 320.0000
carbamazepine RPMI-8226 CTRP1 2.5000 320.0000
carbamazepine SKM-1 CTRP1 2.5000 320.0000
carbamazepine SU-DHL-4 CTRP1 2.5000 320.0000
carbamazepine SU-DHL-5 CTRP1 2.5000 320.0000
carbamazepine THP-1 CTRP1 2.5000 320.0000
carbamazepine U-937 CTRP1 2.5000 320.0000
carbamazepine WSU-DLCL2 CTRP1 2.5000 320.0000
carbamazepine CL-34 CTRP1 2.5000 320.0000
carbamazepine CL-40 CTRP1 2.5000 320.0000
carbamazepine COLO320 CTRP1 2.5000 320.0000
carbamazepine COLO678 CTRP1 2.5000 320.0000
carbamazepine CW-2 CTRP1 2.5000 320.0000
carbamazepine HCT116 CTRP1 2.5000 320.0000
carbamazepine HCT8 CTRP1 2.5000 320.0000
carbamazepine HT115 CTRP1 2.5000 320.0000
carbamazepine HT-29 CTRP1 2.5000 320.0000
carbamazepine HT-55 CTRP1 2.5000 320.0000
carbamazepine KM12 CTRP1 2.5000 320.0000
carbamazepine LOVO CTRP1 2.5000 320.0000
carbamazepine LS123 CTRP1 2.5000 320.0000
carbamazepine MDST8 CTRP1 2.5000 320.0000
carbamazepine NCI-H508 CTRP1 2.5000 320.0000
carbamazepine RCM-1[HUMANESC] CTRP1 2.5000 320.0000
carbamazepine RKO CTRP1 2.5000 320.0000
carbamazepine SNU-1040 CTRP1 2.5000 320.0000
carbamazepine SNU-175 CTRP1 2.5000 320.0000
carbamazepine SNU-61 CTRP1 2.5000 320.0000
carbamazepine SNU-81 CTRP1 2.5000 320.0000
carbamazepine SNU-C4 CTRP1 2.5000 320.0000
carbamazepine SNU-C5 CTRP1 2.5000 320.0000
carbamazepine SW480 CTRP1 2.5000 320.0000
carbamazepine SW620 CTRP1 2.5000 320.0000
carbamazepine SW948 CTRP1 2.5000 320.0000
carbamazepine COR-L23 CTRP1 2.5000 320.0000
carbamazepine HCC15 CTRP1 2.5000 320.0000
carbamazepine NCI-H1755 CTRP1 2.5000 320.0000
carbamazepine NCI-H1781 CTRP1 2.5000 320.0000
carbamazepine NCI-H1836 CTRP1 2.5000 320.0000
carbamazepine NCI-H2073 CTRP1 2.5000 320.0000
carbamazepine NCI-H2110 CTRP1 2.5000 320.0000
carbamazepine NCI-H2122 CTRP1 2.5000 320.0000
carbamazepine NCI-H3255 CTRP1 2.5000 320.0000
carbamazepine NCI-H441 CTRP1 2.5000 320.0000
carbamazepine NCI-H460 CTRP1 2.5000 320.0000
carbamazepine NCI-H596 CTRP1 2.5000 320.0000
carbamazepine SK-LU-1 CTRP1 2.5000 320.0000
carbamazepine T3M-10 CTRP1 2.5000 320.0000
carbamazepine CAOV-3 CTRP1 2.5000 320.0000
carbamazepine COV362 CTRP1 2.5000 320.0000
carbamazepine COV644 CTRP1 2.5000 320.0000
carbamazepine OV7 CTRP1 2.5000 320.0000
carbamazepine OV-90 CTRP1 2.5000 320.0000
carbamazepine RMG-I CTRP1 2.5000 320.0000
carbamazepine RMUG-S CTRP1 2.5000 320.0000
carbamazepine SNU-840 CTRP1 2.5000 320.0000
carbamazepine TYK-NU CTRP1 2.5000 320.0000
carbamazepine A-375 CTRP1 2.5000 320.0000
carbamazepine SK-MEL-1 CTRP1 2.5000 320.0000
carbamazepine SK-MEL-28 CTRP1 2.5000 320.0000
carbamazepine SK-MEL-5 CTRP1 2.5000 320.0000
carbamazepine HT-1080 CTRP1 2.5000 320.0000

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.