Drug : Pk-11195

CTRP1 Name : PK-11195

Dataset : All
Synonyms :
Targets : TSPO
Pathways : inhibitor of translocator protein

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
PK-11195 U2OS CTRP1 4.1667 533.3300
PK-11195 MCF-7 CTRP1 4.1667 533.3300
PK-11195 GAMG CTRP1 0.2603 33.3330
PK-11195 LN-229 CTRP1 4.1667 533.3300
PK-11195 HEC-108 CTRP1 0.2603 33.3330
PK-11195 HEC-151 CTRP1 4.1667 533.3300
PK-11195 HEC-59 CTRP1 0.2603 33.3330
PK-11195 ISHIKAWA(HERAKLIO)02ER- CTRP1 0.2603 33.3330
PK-11195 JHUEM-2 CTRP1 4.1667 533.3300
PK-11195 KLE CTRP1 0.2603 33.3330
PK-11195 SNG-M CTRP1 0.2603 33.3330
PK-11195 AMO1 CTRP1 4.1667 533.3300
PK-11195 BL-70 CTRP1 0.2603 33.3330
PK-11195 EJM CTRP1 4.1667 533.3300
PK-11195 GDM-1 CTRP1 4.1667 533.3300
PK-11195 KMS-11 CTRP1 4.1667 533.3300
PK-11195 LP-1 CTRP1 4.1667 533.3300
PK-11195 MOLM-16 CTRP1 4.1667 533.3300
PK-11195 NOMO-1 CTRP1 4.1667 533.3300
PK-11195 NU-DUL-1 CTRP1 4.1667 533.3300
PK-11195 OCI-AML-3 CTRP1 4.1667 533.3300
PK-11195 OCI-LY10 CTRP1 4.1667 533.3300
PK-11195 PL21 CTRP1 4.1667 533.3300
PK-11195 RPMI-8226 CTRP1 4.1667 533.3300
PK-11195 SKM-1 CTRP1 4.1667 533.3300
PK-11195 SU-DHL-4 CTRP1 4.1667 533.3300
PK-11195 SU-DHL-5 CTRP1 4.1667 533.3300
PK-11195 THP-1 CTRP1 4.1667 533.3300
PK-11195 U-937 CTRP1 4.1667 533.3300
PK-11195 WSU-DLCL2 CTRP1 4.1667 533.3300
PK-11195 RCC10RGB CTRP1 4.1667 533.3300
PK-11195 CL-34 CTRP1 4.1667 533.3300
PK-11195 CL-40 CTRP1 4.1667 533.3300
PK-11195 COLO320 CTRP1 4.1667 533.3300
PK-11195 COLO678 CTRP1 4.1667 533.3300
PK-11195 CW-2 CTRP1 4.1667 533.3300
PK-11195 HCT116 CTRP1 4.1667 533.3300
PK-11195 HCT8 CTRP1 4.1667 533.3300
PK-11195 HT115 CTRP1 4.1667 533.3300
PK-11195 HT-29 CTRP1 4.1667 533.3300
PK-11195 HT-55 CTRP1 4.1667 533.3300
PK-11195 KM12 CTRP1 4.1667 533.3300
PK-11195 LOVO CTRP1 4.1667 533.3300
PK-11195 LS123 CTRP1 4.1667 533.3300
PK-11195 LS180 CTRP1 4.1667 533.3300
PK-11195 MDST8 CTRP1 4.1667 533.3300
PK-11195 NCI-H508 CTRP1 4.1667 533.3300
PK-11195 RCM-1[HUMANESC] CTRP1 4.1667 533.3300
PK-11195 RKO CTRP1 4.1667 533.3300
PK-11195 SNU-1040 CTRP1 4.1667 533.3300
PK-11195 SNU-175 CTRP1 4.1667 533.3300
PK-11195 SNU-61 CTRP1 4.1667 533.3300
PK-11195 SNU-81 CTRP1 4.1667 533.3300
PK-11195 SNU-C4 CTRP1 4.1667 533.3300
PK-11195 SNU-C5 CTRP1 4.1667 533.3300
PK-11195 SW480 CTRP1 4.1667 533.3300
PK-11195 SW620 CTRP1 4.1667 533.3300
PK-11195 SW948 CTRP1 4.1667 533.3300
PK-11195 HEP-G2 CTRP1 4.1667 533.3300
PK-11195 JHH-6 CTRP1 0.2603 33.3330
PK-11195 SNU-398 CTRP1 4.1667 533.3300
PK-11195 SNU-449 CTRP1 0.2603 33.3330
PK-11195 CAL-12T CTRP1 4.1667 533.3300
PK-11195 COLO668 CTRP1 0.2603 33.3330
PK-11195 COLO699 CTRP1 4.1667 533.3300
PK-11195 COR-L23 CTRP1 4.1667 533.3300
PK-11195 COR-L51 CTRP1 4.1667 533.3300
PK-11195 HCC1195 CTRP1 4.1667 533.3300
PK-11195 HCC1359 CTRP1 4.1667 533.3300
PK-11195 HCC15 CTRP1 4.1667 533.3300
PK-11195 HCC1833 CTRP1 4.1667 533.3300
PK-11195 HCC2108 CTRP1 4.1667 533.3300
PK-11195 HCC2935 CTRP1 4.1667 533.3300
PK-11195 HCC4006 CTRP1 4.1667 533.3300
PK-11195 HCC827 CTRP1 4.1667 533.3300
PK-11195 LXF289 CTRP1 0.2603 33.3330
PK-11195 NCI-H1105 CTRP1 4.1667 533.3300
PK-11195 NCI-H1435 CTRP1 0.2603 33.3330
PK-11195 NCI-H1694 CTRP1 4.1667 533.3300
PK-11195 NCI-H1755 CTRP1 4.1667 533.3300
PK-11195 NCI-H1781 CTRP1 4.1667 533.3300
PK-11195 NCI-H1836 CTRP1 4.1667 533.3300
PK-11195 NCI-H1876 CTRP1 4.1667 533.3300
PK-11195 NCI-H1915 CTRP1 0.2603 33.3330
PK-11195 NCI-H1930 CTRP1 0.2603 33.3330
PK-11195 NCI-H1963 CTRP1 4.1667 533.3300
PK-11195 NCI-H2023 CTRP1 4.1667 533.3300
PK-11195 NCI-H2030 CTRP1 4.1667 533.3300
PK-11195 NCI-H2073 CTRP1 4.1667 533.3300
PK-11195 NCI-H2081 CTRP1 4.1667 533.3300
PK-11195 NCI-H2110 CTRP1 4.1667 533.3300
PK-11195 NCI-H2122 CTRP1 4.1667 533.3300
PK-11195 NCI-H2141 CTRP1 4.1667 533.3300
PK-11195 NCI-H2172 CTRP1 4.1667 533.3300
PK-11195 NCI-H2286 CTRP1 0.2603 33.3330
PK-11195 NCI-H2342 CTRP1 4.1667 533.3300
PK-11195 NCI-H3255 CTRP1 4.1667 533.3300
PK-11195 NCI-H441 CTRP1 4.1667 533.3300
PK-11195 NCI-H460 CTRP1 4.1667 533.3300
PK-11195 NCI-H596 CTRP1 4.1667 533.3300
PK-11195 NCI-H841 CTRP1 4.1667 533.3300
PK-11195 RERF-LC-KJ CTRP1 0.2603 33.3330
PK-11195 SCLC-21H CTRP1 4.1667 533.3300
PK-11195 SK-LU-1 CTRP1 4.1667 533.3300
PK-11195 SQ-1 CTRP1 4.1667 533.3300
PK-11195 T3M-10 CTRP1 4.1667 533.3300
PK-11195 A2780 CTRP1 4.1667 533.3300
PK-11195 CAOV-3 CTRP1 4.1667 533.3300
PK-11195 COV318 CTRP1 0.2603 33.3330
PK-11195 COV362 CTRP1 4.1667 533.3300
PK-11195 COV434 CTRP1 4.1667 533.3300
PK-11195 COV644 CTRP1 4.1667 533.3300
PK-11195 EFO-27 CTRP1 4.1667 533.3300
PK-11195 IGROV-1 CTRP1 4.1667 533.3300
PK-11195 JHOC-5 CTRP1 4.1667 533.3300
PK-11195 JHOM-1 CTRP1 4.1667 533.3300
PK-11195 JHOS-4 CTRP1 0.2603 33.3330
PK-11195 OAW42 CTRP1 4.1667 533.3300
PK-11195 OV7 CTRP1 4.1667 533.3300
PK-11195 OV-90 CTRP1 4.1667 533.3300
PK-11195 OVCAR-4 CTRP1 4.1667 533.3300
PK-11195 OVCAR-8 CTRP1 4.1667 533.3300
PK-11195 OVK18 CTRP1 4.1667 533.3300
PK-11195 OVKATE CTRP1 4.1667 533.3300
PK-11195 OVMANA CTRP1 0.2603 33.3330
PK-11195 RKN CTRP1 4.1667 533.3300
PK-11195 RMG-I CTRP1 4.1667 533.3300
PK-11195 RMUG-S CTRP1 4.1667 533.3300
PK-11195 SNU-840 CTRP1 4.1667 533.3300
PK-11195 TYK-NU CTRP1 4.1667 533.3300
PK-11195 PATU8902 CTRP1 0.2603 33.3330
PK-11195 MIAPACA-3 CTRP1 0.2603 33.3330
PK-11195 A-375 CTRP1 4.1667 533.3300
PK-11195 HS852.T CTRP1 0.2603 33.3330
PK-11195 SK-MEL-1 CTRP1 4.1667 533.3300
PK-11195 SK-MEL-28 CTRP1 4.1667 533.3300
PK-11195 SK-MEL-5 CTRP1 4.1667 533.3300
PK-11195 HT-1080 CTRP1 4.1667 533.3300
PK-11195 AGS CTRP1 4.1667 533.3300
PK-11195 MKN74 CTRP1 0.2603 33.3330
PK-11195 SCC-9 CTRP1 4.1667 533.3300

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.