Drug : Mpep

CTRP1 Name : MPEP

Dataset : All
Synonyms :
Targets : GRM5;GRM4
Pathways : antagonist of metabotropic glutamate receptor 5 (mGluR5);positive allosteric modulator at mGluR4 receptors

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
MPEP MCF-7 CTRP1 0.2604 33.3330
MPEP LN-229 CTRP1 0.2604 33.3330
MPEP JHUEM-2 CTRP1 0.2604 33.3330
MPEP EJM CTRP1 0.2604 33.3330
MPEP GDM-1 CTRP1 0.2604 33.3330
MPEP MOLM-16 CTRP1 0.2604 33.3330
MPEP NOMO-1 CTRP1 0.2604 33.3330
MPEP NU-DUL-1 CTRP1 0.2604 33.3330
MPEP OCI-AML-3 CTRP1 0.2604 33.3330
MPEP PL21 CTRP1 0.2604 33.3330
MPEP RPMI-8226 CTRP1 0.2604 33.3330
MPEP SKM-1 CTRP1 0.2604 33.3330
MPEP SU-DHL-4 CTRP1 0.2604 33.3330
MPEP SU-DHL-5 CTRP1 0.2604 33.3330
MPEP THP-1 CTRP1 0.2604 33.3330
MPEP U-937 CTRP1 0.2604 33.3330
MPEP WSU-DLCL2 CTRP1 0.2604 33.3330
MPEP CL-34 CTRP1 0.2604 33.3330
MPEP CL-40 CTRP1 0.2604 33.3330
MPEP COLO320 CTRP1 0.2604 33.3330
MPEP COLO678 CTRP1 0.2604 33.3330
MPEP CW-2 CTRP1 0.2604 33.3330
MPEP HCT116 CTRP1 0.2604 33.3330
MPEP HCT8 CTRP1 0.2604 33.3330
MPEP HT115 CTRP1 0.2604 33.3330
MPEP HT-29 CTRP1 0.2604 33.3330
MPEP HT-55 CTRP1 0.2604 33.3330
MPEP KM12 CTRP1 0.2604 33.3330
MPEP LOVO CTRP1 0.2604 33.3330
MPEP LS123 CTRP1 0.2604 33.3330
MPEP MDST8 CTRP1 0.2604 33.3330
MPEP NCI-H508 CTRP1 0.2604 33.3330
MPEP RCM-1[HUMANESC] CTRP1 0.2604 33.3330
MPEP RKO CTRP1 0.2604 33.3330
MPEP SNU-1040 CTRP1 0.2604 33.3330
MPEP SNU-175 CTRP1 0.2604 33.3330
MPEP SNU-61 CTRP1 0.2604 33.3330
MPEP SNU-81 CTRP1 0.2604 33.3330
MPEP SNU-C4 CTRP1 0.2604 33.3330
MPEP SNU-C5 CTRP1 0.2604 33.3330
MPEP SW480 CTRP1 0.2604 33.3330
MPEP SW620 CTRP1 0.2604 33.3330
MPEP SW948 CTRP1 0.2604 33.3330
MPEP HEP-G2 CTRP1 0.2604 33.3330
MPEP CAL-12T CTRP1 0.2604 33.3330
MPEP COLO699 CTRP1 0.2604 33.3330
MPEP COR-L23 CTRP1 0.2604 33.3330
MPEP HCC1195 CTRP1 0.2604 33.3330
MPEP HCC1359 CTRP1 0.2604 33.3330
MPEP HCC15 CTRP1 0.2604 33.3330
MPEP HCC1833 CTRP1 0.2604 33.3330
MPEP HCC2108 CTRP1 0.2604 33.3330
MPEP HCC2935 CTRP1 0.2604 33.3330
MPEP HCC4006 CTRP1 0.2604 33.3330
MPEP HCC827 CTRP1 0.2604 33.3330
MPEP NCI-H1105 CTRP1 0.2604 33.3330
MPEP NCI-H1694 CTRP1 0.2604 33.3330
MPEP NCI-H1755 CTRP1 0.2604 33.3330
MPEP NCI-H1781 CTRP1 0.2604 33.3330
MPEP NCI-H1836 CTRP1 0.2604 33.3330
MPEP NCI-H1876 CTRP1 0.2604 33.3330
MPEP NCI-H2023 CTRP1 0.2604 33.3330
MPEP NCI-H2030 CTRP1 0.2604 33.3330
MPEP NCI-H2073 CTRP1 0.2604 33.3330
MPEP NCI-H2081 CTRP1 0.2604 33.3330
MPEP NCI-H2110 CTRP1 0.2604 33.3330
MPEP NCI-H2122 CTRP1 0.2604 33.3330
MPEP NCI-H2172 CTRP1 0.2604 33.3330
MPEP NCI-H2342 CTRP1 0.2604 33.3330
MPEP NCI-H3255 CTRP1 0.2604 33.3330
MPEP NCI-H441 CTRP1 0.2604 33.3330
MPEP NCI-H460 CTRP1 0.2604 33.3330
MPEP NCI-H596 CTRP1 0.2604 33.3330
MPEP NCI-H841 CTRP1 0.2604 33.3330
MPEP SK-LU-1 CTRP1 0.2604 33.3330
MPEP SQ-1 CTRP1 0.2604 33.3330
MPEP T3M-10 CTRP1 0.2604 33.3330
MPEP CAOV-3 CTRP1 0.2604 33.3330
MPEP COV362 CTRP1 0.2604 33.3330
MPEP COV434 CTRP1 0.2604 33.3330
MPEP COV644 CTRP1 0.2604 33.3330
MPEP EFO-27 CTRP1 0.2604 33.3330
MPEP JHOC-5 CTRP1 0.2604 33.3330
MPEP JHOM-1 CTRP1 0.2604 33.3330
MPEP OAW42 CTRP1 0.2604 33.3330
MPEP OV7 CTRP1 0.2604 33.3330
MPEP OV-90 CTRP1 0.2604 33.3330
MPEP OVK18 CTRP1 0.2604 33.3330
MPEP RMG-I CTRP1 0.2604 33.3330
MPEP RMUG-S CTRP1 0.2604 33.3330
MPEP SNU-840 CTRP1 0.2604 33.3330
MPEP TYK-NU CTRP1 0.2604 33.3330
MPEP A-375 CTRP1 0.2604 33.3330
MPEP SK-MEL-1 CTRP1 0.2604 33.3330
MPEP SK-MEL-28 CTRP1 0.2604 33.3330
MPEP SK-MEL-5 CTRP1 0.2604 33.3330
MPEP HT-1080 CTRP1 0.2604 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.