Drug : Gsk-2334470

CTRP1 Name : GSK-2334470

Dataset : All
Synonyms :
Targets : PDK1
Pathways : inhibitor of pyruvate dehydrogenase kinase

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
GSK-2334470 MCF-7 CTRP1 0.0026 0.3333
GSK-2334470 LN-229 CTRP1 0.0026 0.3333
GSK-2334470 JHUEM-2 CTRP1 0.0026 0.3333
GSK-2334470 EJM CTRP1 0.0026 0.3333
GSK-2334470 GDM-1 CTRP1 0.0026 0.3333
GSK-2334470 MOLM-16 CTRP1 0.0026 0.3333
GSK-2334470 NOMO-1 CTRP1 0.0026 0.3333
GSK-2334470 NU-DUL-1 CTRP1 0.0026 0.3333
GSK-2334470 OCI-AML-3 CTRP1 0.0026 0.3333
GSK-2334470 PL21 CTRP1 0.0026 0.3333
GSK-2334470 RPMI-8226 CTRP1 0.0026 0.3333
GSK-2334470 SKM-1 CTRP1 0.0026 0.3333
GSK-2334470 SU-DHL-4 CTRP1 0.0026 0.3333
GSK-2334470 SU-DHL-5 CTRP1 0.0026 0.3333
GSK-2334470 THP-1 CTRP1 0.0026 0.3333
GSK-2334470 U-937 CTRP1 0.0026 0.3333
GSK-2334470 WSU-DLCL2 CTRP1 0.0026 0.3333
GSK-2334470 CL-34 CTRP1 0.0026 0.3333
GSK-2334470 CL-40 CTRP1 0.0026 0.3333
GSK-2334470 COLO320 CTRP1 0.0026 0.3333
GSK-2334470 COLO678 CTRP1 0.0026 0.3333
GSK-2334470 CW-2 CTRP1 0.0026 0.3333
GSK-2334470 HCT116 CTRP1 0.0026 0.3333
GSK-2334470 HCT8 CTRP1 0.0026 0.3333
GSK-2334470 HT115 CTRP1 0.0026 0.3333
GSK-2334470 HT-29 CTRP1 0.0026 0.3333
GSK-2334470 HT-55 CTRP1 0.0026 0.3333
GSK-2334470 KM12 CTRP1 0.0026 0.3333
GSK-2334470 LOVO CTRP1 0.0026 0.3333
GSK-2334470 LS123 CTRP1 0.0026 0.3333
GSK-2334470 MDST8 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H508 CTRP1 0.0026 0.3333
GSK-2334470 RCM-1[HUMANESC] CTRP1 0.0026 0.3333
GSK-2334470 RKO CTRP1 0.0026 0.3333
GSK-2334470 SNU-1040 CTRP1 0.0026 0.3333
GSK-2334470 SNU-175 CTRP1 0.0026 0.3333
GSK-2334470 SNU-61 CTRP1 0.0026 0.3333
GSK-2334470 SNU-81 CTRP1 0.0026 0.3333
GSK-2334470 SNU-C4 CTRP1 0.0026 0.3333
GSK-2334470 SNU-C5 CTRP1 0.0026 0.3333
GSK-2334470 SW480 CTRP1 0.0026 0.3333
GSK-2334470 SW620 CTRP1 0.0026 0.3333
GSK-2334470 SW948 CTRP1 0.0026 0.3333
GSK-2334470 HEP-G2 CTRP1 0.0026 0.3333
GSK-2334470 CAL-12T CTRP1 0.0026 0.3333
GSK-2334470 COLO699 CTRP1 0.0026 0.3333
GSK-2334470 COR-L23 CTRP1 0.0026 0.3333
GSK-2334470 HCC1195 CTRP1 0.0026 0.3333
GSK-2334470 HCC1359 CTRP1 0.0026 0.3333
GSK-2334470 HCC15 CTRP1 0.0026 0.3333
GSK-2334470 HCC1833 CTRP1 0.0026 0.3333
GSK-2334470 HCC2108 CTRP1 0.0026 0.3333
GSK-2334470 HCC2935 CTRP1 0.0026 0.3333
GSK-2334470 HCC4006 CTRP1 0.0026 0.3333
GSK-2334470 HCC827 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H1105 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H1694 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H1755 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H1781 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H1836 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H1876 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2023 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2030 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2073 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2081 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2110 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2122 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2172 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H2342 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H3255 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H441 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H460 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H596 CTRP1 0.0026 0.3333
GSK-2334470 NCI-H841 CTRP1 0.0026 0.3333
GSK-2334470 SK-LU-1 CTRP1 0.0026 0.3333
GSK-2334470 SQ-1 CTRP1 0.0026 0.3333
GSK-2334470 T3M-10 CTRP1 0.0026 0.3333
GSK-2334470 CAOV-3 CTRP1 0.0026 0.3333
GSK-2334470 COV362 CTRP1 0.0026 0.3333
GSK-2334470 COV434 CTRP1 0.0026 0.3333
GSK-2334470 COV644 CTRP1 0.0026 0.3333
GSK-2334470 EFO-27 CTRP1 0.0026 0.3333
GSK-2334470 JHOC-5 CTRP1 0.0026 0.3333
GSK-2334470 JHOM-1 CTRP1 0.0026 0.3333
GSK-2334470 OAW42 CTRP1 0.0026 0.3333
GSK-2334470 OV7 CTRP1 0.0026 0.3333
GSK-2334470 OV-90 CTRP1 0.0026 0.3333
GSK-2334470 OVK18 CTRP1 0.0026 0.3333
GSK-2334470 RMG-I CTRP1 0.0026 0.3333
GSK-2334470 RMUG-S CTRP1 0.0026 0.3333
GSK-2334470 SNU-840 CTRP1 0.0026 0.3333
GSK-2334470 TYK-NU CTRP1 0.0026 0.3333
GSK-2334470 A-375 CTRP1 0.0026 0.3333
GSK-2334470 SK-MEL-1 CTRP1 0.0026 0.3333
GSK-2334470 SK-MEL-28 CTRP1 0.0026 0.3333
GSK-2334470 SK-MEL-5 CTRP1 0.0026 0.3333
GSK-2334470 HT-1080 CTRP1 0.0026 0.3333

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.