CREAMMIST

Drug : Asn 05257430

CTRP2 Name : ML083
CTRP1 Name : ASN 05257430

Dataset : All
Synonyms :
Targets : PKM
Pathways : activator of muscle pyruvate kinase (PKM2)

Information Cards

Click to show/hide information cards below or download all drug response information.

Experiment Information IC50 IC90 AUC
Associated Genes (Mutation) Associated Genes (Gene Expression)

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

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Drug name	Cellosaurus ID	Original Dataset(s)	Min Dose	Max Dose
ASN 05257430	MCF-7	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	GAMG	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	LN-229	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	SF295	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	HEC-108	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	HEC-151	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	HEC-251	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	HEC-265	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	HEC-59	CTRP2,CTRP1	0.0011	37.0000
ASN 05257430	HEC-6	CTRP2,CTRP1	0.0011	37.0000

Showing 1 to 10 of 848 entries

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.