Drug : Vx-680

CTRP2 Name : VX-680

Dataset : All
Synonyms :
Targets : AURKA;AURKB;AURKC
Pathways : inhibitor of aurora kinases

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
VX-680 KE-39 CTRP2 0.0020 66.0000
VX-680 DMS454 CTRP2 0.0020 66.0000
VX-680 GCT CTRP2 0.0020 66.0000
VX-680 HCC2935 CTRP2 0.0020 66.0000
VX-680 HOP-62 CTRP2 0.0020 66.0000
VX-680 NCI-H747 CTRP2 0.0020 66.0000
VX-680 OVCAR-5 CTRP2 0.0020 66.0000
VX-680 SF268 CTRP2 0.0020 66.0000
VX-680 SF539 CTRP2 0.0020 66.0000
VX-680 TUHR14TKB CTRP2 0.5200 66.0000
VX-680 U-251MG CTRP2 0.0020 66.0000
VX-680 DMS53 CTRP2 0.0020 66.0000
VX-680 HEC-1-A CTRP2 0.0020 66.0000
VX-680 IGR-37 CTRP2 0.0020 66.0000
VX-680 KNS-62 CTRP2 0.0020 66.0000
VX-680 MDA-MB-157 CTRP2 0.0020 66.0000
VX-680 NCI-H1563 CTRP2 0.0020 66.0000
VX-680 OC314 CTRP2 0.0020 66.0000
VX-680 UO-31 CTRP2 0.0020 66.0000
VX-680 BICR56 CTRP2 0.0020 66.0000
VX-680 CAL-33 CTRP2 0.0020 66.0000
VX-680 CALU-1 CTRP2 0.0020 66.0000
VX-680 CAPAN-2 CTRP2 0.0020 66.0000
VX-680 DMS114 CTRP2 0.0020 66.0000
VX-680 EKVX CTRP2 0.0020 66.0000
VX-680 HCC1438 CTRP2 0.0020 66.0000
VX-680 HCT8 CTRP2 0.0020 66.0000
VX-680 HOP-92 CTRP2 0.5200 66.0000
VX-680 KYM-1 CTRP2 0.0020 66.0000
VX-680 KYSE-30 CTRP2 0.0020 66.0000
VX-680 KYSE-510 CTRP2 0.0020 66.0000
VX-680 L-428 CTRP2 0.0020 66.0000
VX-680 MDA-MB-361 CTRP2 0.5200 66.0000
VX-680 MFE-296 CTRP2 0.0020 66.0000
VX-680 NU-DHL-1 CTRP2 0.0020 66.0000
VX-680 SNB-75 CTRP2 0.0020 66.0000
VX-680 SNU-216 CTRP2 0.0020 66.0000
VX-680 BICR16 CTRP2 0.0020 66.0000
VX-680 F-36P CTRP2 0.0020 66.0000
VX-680 JJN-3 CTRP2 0.0020 66.0000
VX-680 KASUMI-2 CTRP2 0.0020 66.0000
VX-680 KG-1-C CTRP2 0.0020 66.0000
VX-680 KMS-20 CTRP2 0.0020 66.0000
VX-680 KYSE-150 CTRP2 0.0020 66.0000
VX-680 OCI-AML-5 CTRP2 0.0020 66.0000
VX-680 PANC08.13 CTRP2 0.0020 66.0000
VX-680 SNU-601 CTRP2 0.0020 66.0000
VX-680 SNU-C4 CTRP2 0.0020 66.0000
VX-680 T-47D CTRP2 0.0020 66.0000
VX-680 T84 CTRP2 0.0020 66.0000
VX-680 TE-14 CTRP2 0.0020 66.0000
VX-680 U266B1 CTRP2 0.0020 66.0000
VX-680 42-MG-BA CTRP2 0.0020 66.0000
VX-680 BT139 CTRP2 0.0020 66.0000
VX-680 BT159 CTRP2 0.0020 66.0000
VX-680 BT187 CTRP2 0.0020 66.0000
VX-680 BT228 CTRP2 0.0020 66.0000
VX-680 BT231 CTRP2 0.0020 66.0000
VX-680 BT239 CTRP2 0.0020 66.0000
VX-680 BT-474 CTRP2 0.0020 66.0000
VX-680 COV434 CTRP2 0.0020 66.0000
VX-680 DND-41 CTRP2 0.0020 66.0000
VX-680 G-292CLONEA141B1 CTRP2 0.0020 66.0000
VX-680 HCC2218 CTRP2 0.0020 66.0000
VX-680 HS766T CTRP2 0.0020 66.0000
VX-680 M-07E CTRP2 0.0020 66.0000
VX-680 NCI-H1651 CTRP2 0.0020 66.0000
VX-680 SK-BR-3 CTRP2 0.0020 66.0000
VX-680 A-204 CTRP2 0.0020 66.0000
VX-680 AML-193 CTRP2 0.0020 66.0000
VX-680 HGC-27 CTRP2 0.0020 66.0000
VX-680 HS578BST CTRP2 0.0020 66.0000
VX-680 MALME-3M CTRP2 0.0020 66.0000
VX-680 HS934.T CTRP2 0.0020 66.0000
VX-680 HS688(A).T CTRP2 0.0020 66.0000
VX-680 HUT78 CTRP2 0.0020 66.0000
VX-680 NCI-H1793 CTRP2 0.0020 66.0000
VX-680 SCC-4 CTRP2 0.0020 66.0000
VX-680 SK-ES-1 CTRP2 0.0020 66.0000
VX-680 HS888.T CTRP2 0.0020 66.0000
VX-680 MDA-MB-453 CTRP2 0.0020 66.0000
VX-680 NCI-H660 CTRP2 0.0020 66.0000
VX-680 SAOS-2 CTRP2 0.0020 66.0000
VX-680 U-BLC1 CTRP2 0.0020 66.0000
VX-680 BT248 CTRP2 0.0020 66.0000
VX-680 NCI-H1694 CTRP2 0.0020 66.0000
VX-680 SEM CTRP2 0.0020 66.0000
VX-680 HS822.T CTRP2 0.0020 66.0000
VX-680 HS940.T CTRP2 0.0020 66.0000
VX-680 KMBC-2 CTRP2 0.0020 66.0000
VX-680 RCC10RGB CTRP2 0.0020 66.0000
VX-680 SK-N-BE(2) CTRP2 0.0020 66.0000
VX-680 AU565 CTRP2 0.0020 66.0000
VX-680 COLO320 CTRP2 0.0020 66.0000
VX-680 MDA-MB-415 CTRP2 0.0020 66.0000
VX-680 PANC10.05 CTRP2 0.0020 66.0000
VX-680 BT131 CTRP2 0.0020 66.0000
VX-680 BT147 CTRP2 0.0020 66.0000
VX-680 BT172 CTRP2 0.0020 66.0000
VX-680 BT216 CTRP2 0.0020 66.0000
VX-680 BT232 CTRP2 0.0020 66.0000
VX-680 BT245 CTRP2 0.0020 66.0000
VX-680 BT271 CTRP2 0.0020 66.0000
VX-680 BT286 CTRP2 0.0020 66.0000
VX-680 BT320 CTRP2 0.0020 66.0000
VX-680 BT328 CTRP2 0.0020 66.0000
VX-680 BT330 CTRP2 0.0020 66.0000
VX-680 BT333 CTRP2 0.0020 66.0000
VX-680 BT340 CTRP2 0.0020 66.0000
VX-680 BT359 CTRP2 0.0020 66.0000
VX-680 BT416 CTRP2 0.0020 66.0000
VX-680 BT422 CTRP2 0.0020 66.0000
VX-680 BT428 CTRP2 0.0020 66.0000
VX-680 BT440 CTRP2 0.0020 66.0000
VX-680 BT444 CTRP2 0.0020 66.0000
VX-680 BT482 CTRP2 0.0020 66.0000
VX-680 BT498 CTRP2 0.0020 66.0000
VX-680 BT504 CTRP2 0.0020 66.0000
VX-680 2004 CTRP2 0.0020 66.0000
VX-680 ASKA-SS CTRP2 0.0020 66.0000
VX-680 BT-12 CTRP2 0.0020 66.0000
VX-680 BT-16 CTRP2 0.0020 66.0000
VX-680 SW982 CTRP2 0.0020 66.0000
VX-680 SYO-1 CTRP2 0.0020 66.0000
VX-680 TM87-16 CTRP2 0.0020 66.0000
VX-680 TTC-709 CTRP2 0.0020 66.0000
VX-680 YAMATO-SS CTRP2 0.0020 66.0000

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.