Drug : Uk 356618

CTRP1 Name : UK 356618

Dataset : All
Synonyms :
Targets : MMP3
Pathways : inhibitor of matrix metallopeptidase 3

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
UK 356618 LN-229 CTRP1 0.2604 33.3330
UK 356618 JHUEM-2 CTRP1 0.2604 33.3330
UK 356618 GDM-1 CTRP1 0.2604 33.3330
UK 356618 MOLM-16 CTRP1 0.2604 33.3330
UK 356618 NOMO-1 CTRP1 0.2604 33.3330
UK 356618 NU-DUL-1 CTRP1 0.2604 33.3330
UK 356618 OCI-AML-3 CTRP1 0.2604 33.3330
UK 356618 PL21 CTRP1 0.2604 33.3330
UK 356618 RPMI-8226 CTRP1 0.2604 33.3330
UK 356618 SKM-1 CTRP1 0.2604 33.3330
UK 356618 SU-DHL-4 CTRP1 0.2604 33.3330
UK 356618 SU-DHL-5 CTRP1 0.2604 33.3330
UK 356618 THP-1 CTRP1 0.2604 33.3330
UK 356618 U-937 CTRP1 0.2604 33.3330
UK 356618 WSU-DLCL2 CTRP1 0.2604 33.3330
UK 356618 CL-34 CTRP1 0.2604 33.3330
UK 356618 CL-40 CTRP1 0.2604 33.3330
UK 356618 COLO678 CTRP1 0.2604 33.3330
UK 356618 HCT116 CTRP1 0.2604 33.3330
UK 356618 HCT8 CTRP1 0.2604 33.3330
UK 356618 HT115 CTRP1 0.2604 33.3330
UK 356618 HT-29 CTRP1 0.2604 33.3330
UK 356618 HT-55 CTRP1 0.2604 33.3330
UK 356618 LOVO CTRP1 0.2604 33.3330
UK 356618 LS123 CTRP1 0.2604 33.3330
UK 356618 MDST8 CTRP1 0.2604 33.3330
UK 356618 NCI-H508 CTRP1 0.2604 33.3330
UK 356618 RCM-1[HUMANESC] CTRP1 0.2604 33.3330
UK 356618 RKO CTRP1 0.2604 33.3330
UK 356618 SNU-1040 CTRP1 0.2604 33.3330
UK 356618 SW480 CTRP1 0.2604 33.3330
UK 356618 SW620 CTRP1 0.2604 33.3330
UK 356618 HCC15 CTRP1 0.2604 33.3330
UK 356618 NCI-H1755 CTRP1 0.2604 33.3330
UK 356618 NCI-H1781 CTRP1 0.2604 33.3330
UK 356618 NCI-H2122 CTRP1 0.2604 33.3330
UK 356618 NCI-H441 CTRP1 0.2604 33.3330
UK 356618 NCI-H460 CTRP1 0.2604 33.3330
UK 356618 NCI-H596 CTRP1 0.2604 33.3330
UK 356618 SK-LU-1 CTRP1 0.2604 33.3330
UK 356618 T3M-10 CTRP1 0.2604 33.3330
UK 356618 CAOV-3 CTRP1 0.2604 33.3330
UK 356618 COV644 CTRP1 0.2604 33.3330
UK 356618 OV7 CTRP1 0.2604 33.3330
UK 356618 OV-90 CTRP1 0.2604 33.3330
UK 356618 RMUG-S CTRP1 0.2604 33.3330
UK 356618 SNU-840 CTRP1 0.2604 33.3330
UK 356618 TYK-NU CTRP1 0.2604 33.3330
UK 356618 A-375 CTRP1 0.2604 33.3330
UK 356618 SK-MEL-1 CTRP1 0.2604 33.3330
UK 356618 SK-MEL-28 CTRP1 0.2604 33.3330
UK 356618 SK-MEL-5 CTRP1 0.2604 33.3330
UK 356618 HT-1080 CTRP1 0.2604 33.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.