Drug : Compound 11E

CTRP1 Name : Compound 11e

Dataset : All
Synonyms :
Targets : MAPK1
Pathways : inhibitor of ERK

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
Compound 11e MCF-7 CTRP1 0.0130 1.6667
Compound 11e LN-229 CTRP1 0.0130 1.6667
Compound 11e JHUEM-2 CTRP1 0.0130 1.6667
Compound 11e EJM CTRP1 0.0130 1.6667
Compound 11e GDM-1 CTRP1 0.0130 1.6667
Compound 11e MOLM-16 CTRP1 0.0130 1.6667
Compound 11e NOMO-1 CTRP1 0.0130 1.6667
Compound 11e NU-DUL-1 CTRP1 0.0130 1.6667
Compound 11e OCI-AML-3 CTRP1 0.0130 1.6667
Compound 11e PL21 CTRP1 0.0130 1.6667
Compound 11e RPMI-8226 CTRP1 0.0130 1.6667
Compound 11e SKM-1 CTRP1 0.0130 1.6667
Compound 11e SU-DHL-4 CTRP1 0.0130 1.6667
Compound 11e SU-DHL-5 CTRP1 0.0130 1.6667
Compound 11e THP-1 CTRP1 0.0130 1.6667
Compound 11e U-937 CTRP1 0.0130 1.6667
Compound 11e WSU-DLCL2 CTRP1 0.0130 1.6667
Compound 11e CL-34 CTRP1 0.0130 1.6667
Compound 11e CL-40 CTRP1 0.0130 1.6667
Compound 11e COLO320 CTRP1 0.0130 1.6667
Compound 11e COLO678 CTRP1 0.0130 1.6667
Compound 11e CW-2 CTRP1 0.0130 1.6667
Compound 11e HCT116 CTRP1 0.0130 1.6667
Compound 11e HCT8 CTRP1 0.0130 1.6667
Compound 11e HT115 CTRP1 0.0130 1.6667
Compound 11e HT-29 CTRP1 0.0130 1.6667
Compound 11e HT-55 CTRP1 0.0130 1.6667
Compound 11e KM12 CTRP1 0.0130 1.6667
Compound 11e LOVO CTRP1 0.0130 1.6667
Compound 11e LS123 CTRP1 0.0130 1.6667
Compound 11e MDST8 CTRP1 0.0130 1.6667
Compound 11e NCI-H508 CTRP1 0.0130 1.6667
Compound 11e RCM-1[HUMANESC] CTRP1 0.0130 1.6667
Compound 11e RKO CTRP1 0.0130 1.6667
Compound 11e SNU-1040 CTRP1 0.0130 1.6667
Compound 11e SNU-175 CTRP1 0.0130 1.6667
Compound 11e SNU-61 CTRP1 0.0130 1.6667
Compound 11e SNU-81 CTRP1 0.0130 1.6667
Compound 11e SNU-C4 CTRP1 0.0130 1.6667
Compound 11e SNU-C5 CTRP1 0.0130 1.6667
Compound 11e SW480 CTRP1 0.0130 1.6667
Compound 11e SW620 CTRP1 0.0130 1.6667
Compound 11e SW948 CTRP1 0.0130 1.6667
Compound 11e HEP-G2 CTRP1 0.0130 1.6667
Compound 11e CAL-12T CTRP1 0.0130 1.6667
Compound 11e COLO699 CTRP1 0.0130 1.6667
Compound 11e COR-L23 CTRP1 0.0130 1.6667
Compound 11e HCC1195 CTRP1 0.0130 1.6667
Compound 11e HCC1359 CTRP1 0.0130 1.6667
Compound 11e HCC15 CTRP1 0.0130 1.6667
Compound 11e HCC1833 CTRP1 0.0130 1.6667
Compound 11e HCC2108 CTRP1 0.0130 1.6667
Compound 11e HCC2935 CTRP1 0.0130 1.6667
Compound 11e HCC4006 CTRP1 0.0130 1.6667
Compound 11e HCC827 CTRP1 0.0130 1.6667
Compound 11e NCI-H1105 CTRP1 0.0130 1.6667
Compound 11e NCI-H1694 CTRP1 0.0130 1.6667
Compound 11e NCI-H1755 CTRP1 0.0130 1.6667
Compound 11e NCI-H1781 CTRP1 0.0130 1.6667
Compound 11e NCI-H1836 CTRP1 0.0130 1.6667
Compound 11e NCI-H1876 CTRP1 0.0130 1.6667
Compound 11e NCI-H2023 CTRP1 0.0130 1.6667
Compound 11e NCI-H2030 CTRP1 0.0130 1.6667
Compound 11e NCI-H2073 CTRP1 0.0130 1.6667
Compound 11e NCI-H2081 CTRP1 0.0130 1.6667
Compound 11e NCI-H2110 CTRP1 0.0130 1.6667
Compound 11e NCI-H2122 CTRP1 0.0130 1.6667
Compound 11e NCI-H2172 CTRP1 0.0130 1.6667
Compound 11e NCI-H2342 CTRP1 0.0130 1.6667
Compound 11e NCI-H3255 CTRP1 0.0130 1.6667
Compound 11e NCI-H441 CTRP1 0.0130 1.6667
Compound 11e NCI-H460 CTRP1 0.0130 1.6667
Compound 11e NCI-H596 CTRP1 0.0130 1.6667
Compound 11e NCI-H841 CTRP1 0.0130 1.6667
Compound 11e SK-LU-1 CTRP1 0.0130 1.6667
Compound 11e SQ-1 CTRP1 0.0130 1.6667
Compound 11e T3M-10 CTRP1 0.0130 1.6667
Compound 11e CAOV-3 CTRP1 0.0130 1.6667
Compound 11e COV362 CTRP1 0.0130 1.6667
Compound 11e COV434 CTRP1 0.0130 1.6667
Compound 11e COV644 CTRP1 0.0130 1.6667
Compound 11e EFO-27 CTRP1 0.0130 1.6667
Compound 11e JHOC-5 CTRP1 0.0130 1.6667
Compound 11e JHOM-1 CTRP1 0.0130 1.6667
Compound 11e OAW42 CTRP1 0.0130 1.6667
Compound 11e OV7 CTRP1 0.0130 1.6667
Compound 11e OV-90 CTRP1 0.0130 1.6667
Compound 11e OVK18 CTRP1 0.0130 1.6667
Compound 11e RMG-I CTRP1 0.0130 1.6667
Compound 11e RMUG-S CTRP1 0.0130 1.6667
Compound 11e SNU-840 CTRP1 0.0130 1.6667
Compound 11e TYK-NU CTRP1 0.0130 1.6667
Compound 11e A-375 CTRP1 0.0130 1.6667
Compound 11e SK-MEL-1 CTRP1 0.0130 1.6667
Compound 11e SK-MEL-28 CTRP1 0.0130 1.6667
Compound 11e SK-MEL-5 CTRP1 0.0130 1.6667
Compound 11e HT-1080 CTRP1 0.0130 1.6667

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.