Drug : Ag14361

CTRP1 Name : AG14361

Dataset : All
Synonyms :
Targets : PARP1
Pathways : inhibitor of poly (ADP-ribose) polymerase 1

Information Cards

Click to show/hide information cards below or download all drug response information.

           
     

Information cards below will change according to the dataset selected. The default dataset is “All”, which means information in the cards is based on the integration. If “All” is not selected, information cards will contain drug response information preprocessed for each dataset independently.

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Experimental information

Experimental information from All dataset, including drug name, cell line name, and minimum and maximum dosages used in each experiment. Click on Dose-response to query more detail for each experiment.

Drug name Cellosaurus ID Original Dataset(s) Min Dose Max Dose Dose-response
AG14361 LN-229 CTRP1 0.6510 83.3330
AG14361 JHUEM-2 CTRP1 0.6510 83.3330
AG14361 GDM-1 CTRP1 0.6510 83.3330
AG14361 MOLM-16 CTRP1 0.6510 83.3330
AG14361 NOMO-1 CTRP1 0.6510 83.3330
AG14361 NU-DUL-1 CTRP1 0.6510 83.3330
AG14361 OCI-AML-3 CTRP1 0.6510 83.3330
AG14361 PL21 CTRP1 0.6510 83.3330
AG14361 RPMI-8226 CTRP1 0.6510 83.3330
AG14361 SKM-1 CTRP1 0.6510 83.3330
AG14361 SU-DHL-4 CTRP1 0.6510 83.3330
AG14361 SU-DHL-5 CTRP1 0.6510 83.3330
AG14361 THP-1 CTRP1 0.6510 83.3330
AG14361 U-937 CTRP1 0.6510 83.3330
AG14361 WSU-DLCL2 CTRP1 0.6510 83.3330
AG14361 CL-34 CTRP1 0.6510 83.3330
AG14361 CL-40 CTRP1 0.6510 83.3330
AG14361 COLO678 CTRP1 0.6510 83.3330
AG14361 HCT116 CTRP1 0.6510 83.3330
AG14361 HCT8 CTRP1 0.6510 83.3330
AG14361 HT115 CTRP1 0.6510 83.3330
AG14361 HT-29 CTRP1 0.6510 83.3330
AG14361 HT-55 CTRP1 0.6510 83.3330
AG14361 LOVO CTRP1 0.6510 83.3330
AG14361 LS123 CTRP1 0.6510 83.3330
AG14361 MDST8 CTRP1 0.6510 83.3330
AG14361 NCI-H508 CTRP1 0.6510 83.3330
AG14361 RCM-1[HUMANESC] CTRP1 0.6510 83.3330
AG14361 RKO CTRP1 0.6510 83.3330
AG14361 SNU-1040 CTRP1 0.6510 83.3330
AG14361 SW480 CTRP1 0.6510 83.3330
AG14361 SW620 CTRP1 0.6510 83.3330
AG14361 HCC15 CTRP1 0.6510 83.3330
AG14361 NCI-H1755 CTRP1 0.6510 83.3330
AG14361 NCI-H1781 CTRP1 0.6510 83.3330
AG14361 NCI-H2122 CTRP1 0.6510 83.3330
AG14361 NCI-H441 CTRP1 0.6510 83.3330
AG14361 NCI-H460 CTRP1 0.6510 83.3330
AG14361 NCI-H596 CTRP1 0.6510 83.3330
AG14361 SK-LU-1 CTRP1 0.6510 83.3330
AG14361 T3M-10 CTRP1 0.6510 83.3330
AG14361 CAOV-3 CTRP1 0.6510 83.3330
AG14361 COV644 CTRP1 0.6510 83.3330
AG14361 OV7 CTRP1 0.6510 83.3330
AG14361 OV-90 CTRP1 0.6510 83.3330
AG14361 RMUG-S CTRP1 0.6510 83.3330
AG14361 SNU-840 CTRP1 0.6510 83.3330
AG14361 TYK-NU CTRP1 0.6510 83.3330
AG14361 A-375 CTRP1 0.6510 83.3330
AG14361 SK-MEL-1 CTRP1 0.6510 83.3330
AG14361 SK-MEL-28 CTRP1 0.6510 83.3330
AG14361 SK-MEL-5 CTRP1 0.6510 83.3330
AG14361 HT-1080 CTRP1 0.6510 83.3330

IC50

IC50 indicates how much drug dosage is needed to inhibit the cells by 50%, in vitro, compared to the control well.

Cell lines with highest and lowest IC50

IC90

IC90 indicates how much drug dosage is needed to inhibit the cells by 90%, in vitro, compared to the control well.

Cell lines with highest and lowest IC90

AUC

AUC represents the area under a dose-response curve, where 0% indicates no activity and 100% indicates that a drug completely inhibits the cells across testing dosages.

Cell lines with highest and lowest AUC

Associated Genes (Mutation)

Genes with the largest and lowest Racksum’s effect sizes, calculated by comparing IC50 between the mutant and wide type cell lines using cell lines from pancan data.

Associated Genes (Gene Expression)

Genes with the highest and lowest Spearman correlations, calculated by comparing gene expression and IC50 across cell lines from pancan data.