Biomarker information

Drug-gene associations based on IC50 and mutation (or gene expression) profile. IC50 value was estimated using the integrated dose-response curve.

Gene : CEACAM5
Drug Name : PLX-4720
Cancer type : pancan

Association Information

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Drug-gene association (IC50 vs mutation)

Ranksum’s effect size was calculated by comparing IC50 between mutant and wide-type cell lines (more detail).

−1−0.500.511.522.5CCLEGDSC1GDSC2CTRP2All
CREAMMISTOriginal sourceEffect sizeDataset

Drug-gene association (IC50 vs gene expression)

Spearman correlation was calculated by comparing IC50 and gene expression (TMM) across cell lines (more detail).

−0.500.51GDSC2All
CREAMMISTOriginal sourceSpearman correlationDataset

IC50 vs mutation

Relationships between IC50 and mutation profiles base on "All" dataset.

MutantWild-type−202468
IC50 Log2 Concentration (μM)N = 120N = 1027

IC50 vs gene expression

Relationships between IC50 and gene expression profiles base on "All" dataset.

−50510−20246810
Gene expression (Log2 TPM)IC50 Log2 Concentration (μM)