Biomarker information

Drug-gene associations based on IC50 and mutation (or gene expression) profile. IC50 value was estimated using the integrated dose-response curve.

Gene : ARHGAP29
Drug Name : cytarabine hydrochloride
Cancer type : pancan

Association Information

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Drug-gene association (IC50 vs mutation)

Ranksum’s effect size was calculated by comparing IC50 between mutant and wide-type cell lines (more detail).

−3−2.5−2−1.5CTRP2All
CREAMMISTEffect sizeDataset

Drug-gene association (IC50 vs gene expression)

Spearman correlation was calculated by comparing IC50 and gene expression (TMM) across cell lines (more detail).

00.511.5CTRP2All
CREAMMISTSpearman correlationDataset

IC50 vs mutation

Relationships between IC50 and mutation profiles base on "All" dataset.

MutantWild-type−10−5051015
IC50 Log2 Concentration (μM)N = 44N = 659

IC50 vs gene expression

Relationships between IC50 and gene expression profiles base on "All" dataset.

−6−4−202468−10−5051015
Gene expression (Log2 TPM)IC50 Log2 Concentration (μM)